Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQN42_RS04490 Genome accession   NZ_LS483436
Coordinates   911412..912086 (+) Length   224 a.a.
NCBI ID   WP_003036714.1    Uniprot ID   -
Organism   Streptococcus intermedius strain NCTC11324     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 906412..917086
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN42_RS04465 (NCTC11324_00903) - 907967..908926 (+) 960 WP_003076829.1 ROK family glucokinase -
  DQN42_RS04470 (NCTC11324_00904) rplS 909076..909423 (+) 348 WP_003024326.1 50S ribosomal protein L19 -
  DQN42_RS04480 (NCTC11324_00906) - 909668..910408 (+) 741 WP_003076545.1 alpha/beta hydrolase -
  DQN42_RS04485 (NCTC11324_00907) - 910707..911150 (+) 444 WP_003076363.1 hypothetical protein -
  DQN42_RS04490 (NCTC11324_00908) ciaR 911412..912086 (+) 675 WP_003036714.1 response regulator transcription factor Regulator
  DQN42_RS04495 (NCTC11324_00909) ciaH 912076..913422 (+) 1347 WP_003076259.1 cell wall metabolism sensor histidine kinase WalK Regulator
  DQN42_RS04500 (NCTC11324_00910) - 913698..915146 (-) 1449 WP_003076940.1 alpha-amylase -
  DQN42_RS04505 (NCTC11324_00911) - 915537..916046 (-) 510 WP_003076684.1 DNA topology modulation protein -
  DQN42_RS04510 (NCTC11324_00912) rpsT 916111..916347 (-) 237 WP_003072853.1 30S ribosomal protein S20 -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25373.03 Da        Isoelectric Point: 4.2408

>NTDB_id=1141442 DQN42_RS04490 WP_003036714.1 911412..912086(+) (ciaR) [Streptococcus intermedius strain NCTC11324]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTINLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1141442 DQN42_RS04490 WP_003036714.1 911412..912086(+) (ciaR) [Streptococcus intermedius strain NCTC11324]
ATGATTAAGATTCTATTAGTAGAAGATGACCTCGGTTTATCTAACTCAGTATTTGATTTTTTAGATGACTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAGGAAGGATTGTACGAAGCTGAAAGTGGTGTGTATGATCTTATCTTACTTGATTTGATGT
TACCGGAAAAAGATGGTTTTCAAGTATTGAAGGAATTACGTGAAAAAGGTGTTACAACACCGGTATTGATTATGACAGCT
AAAGAGAGTTTGAATGATAAAGGACATGGCTTTGAGCTGGGAGCTGACGATTATTTGACCAAACCATTTTATTTGGAAGA
GTTAAAAATGCGGATTCAAGCTCTTTTGAAACGATCGGGCAAGTTTAATGAAAATACTCTTTCTTATGGTGATGTAACCA
TTAATTTGTCAACGAACACTACACTTGTAGATGGAAATGAAGTAGAGTTACTCGGAAAAGAATTTGATTTATTAGTATAT
TTCTTGCAGAATCAAAATGTTATTCTACCGAAGACGCAGATTTTCGATCGATTATGGGGGTTTGATAGTGATACAACCAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATTCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAACCTTCAAACGCTTC
GCAGCGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.518

100

0.915
  ciaR Streptococcus pneumoniae D39

91.518

100

0.915
  ciaR Streptococcus pneumoniae R6

91.518

100

0.915
  ciaR Streptococcus pneumoniae TIGR4

91.518

100

0.915
  ciaR Streptococcus mutans UA159

89.686

99.554

0.893
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment