Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   DQN42_RS04495 Genome accession   NZ_LS483436
Coordinates   912076..913422 (+) Length   448 a.a.
NCBI ID   WP_003076259.1    Uniprot ID   -
Organism   Streptococcus intermedius strain NCTC11324     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 907076..918422
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN42_RS04465 (NCTC11324_00903) - 907967..908926 (+) 960 WP_003076829.1 ROK family glucokinase -
  DQN42_RS04470 (NCTC11324_00904) rplS 909076..909423 (+) 348 WP_003024326.1 50S ribosomal protein L19 -
  DQN42_RS04480 (NCTC11324_00906) - 909668..910408 (+) 741 WP_003076545.1 alpha/beta hydrolase -
  DQN42_RS04485 (NCTC11324_00907) - 910707..911150 (+) 444 WP_003076363.1 hypothetical protein -
  DQN42_RS04490 (NCTC11324_00908) ciaR 911412..912086 (+) 675 WP_003036714.1 response regulator transcription factor Regulator
  DQN42_RS04495 (NCTC11324_00909) ciaH 912076..913422 (+) 1347 WP_003076259.1 cell wall metabolism sensor histidine kinase WalK Regulator
  DQN42_RS04500 (NCTC11324_00910) - 913698..915146 (-) 1449 WP_003076940.1 alpha-amylase -
  DQN42_RS04505 (NCTC11324_00911) - 915537..916046 (-) 510 WP_003076684.1 DNA topology modulation protein -
  DQN42_RS04510 (NCTC11324_00912) rpsT 916111..916347 (-) 237 WP_003072853.1 30S ribosomal protein S20 -
  DQN42_RS04515 (NCTC11324_00913) coaA 916416..917336 (-) 921 WP_003076842.1 type I pantothenate kinase -
  DQN42_RS04520 (NCTC11324_00914) - 917429..918022 (+) 594 WP_003076784.1 class I SAM-dependent methyltransferase -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50926.65 Da        Isoelectric Point: 10.1689

>NTDB_id=1141443 DQN42_RS04495 WP_003076259.1 912076..913422(+) (ciaH) [Streptococcus intermedius strain NCTC11324]
MLNKLKKAWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARKVGLEQKSENGE
PKSGTADKELTDKPNVSANTEVILFDKNYKSIITSNNFLGFNKLSFNSKQLDRIRQIQVKSNYGREETYRMVLFQVKLPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDIEPNFFNTTFTNYEMVATENGKVFRF
DNRIHRVIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISSNDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTITVKDNKPKGTVFEVKIAIRTDNKKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=1141443 DQN42_RS04495 WP_003076259.1 912076..913422(+) (ciaH) [Streptococcus intermedius strain NCTC11324]
ATGCTGAATAAACTAAAAAAAGCATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCTATGACCTTGATTATCATTCAAGTTATGCGCTCAAGCCTTTATACAACGGTAGATAATAATTTAAAAAGCT
TGAGTCAAGATTCGGCTTCTGTGATTAATTTAGCGCTTGCTCGAAAAGTAGGGCTAGAGCAAAAGTCAGAAAATGGAGAG
CCTAAAAGTGGAACAGCTGATAAAGAGCTGACAGATAAACCAAATGTGAGTGCCAATACAGAAGTTATTTTATTTGATAA
GAATTATAAATCAATTATTACAAGCAATAATTTTTTAGGGTTTAATAAACTTTCCTTTAATAGCAAGCAATTAGATCGTA
TTCGTCAAATTCAAGTAAAAAGCAATTACGGCCGAGAAGAAACCTATCGGATGGTTTTGTTTCAAGTGAAATTGCCTAAT
TTAGAAACCAATGTCAAATACGCAGCAGTTTTTATCAATATTAGCCAATTGGAACAAACTAGTCAAAACCATGAACAGTT
GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCTAGTGTCTATCTTGCGCGAGTAAGTGTCAAACCGC
TTTTGGAAAGTATTCAAAAACAAAAGAGCTTTGTCGAAAATGCTAGTCATGAATTACGCACACCTTTAGCCGTTTTGCAA
AATCGTTTGGAGACTTTGTTTAGAAAACCAGAAGCTACCATTATGGAATCGAGTGAAAGCATCGCTTCTAGTTTAGATGA
AGTGCGAAACATGAAAATGTTGACAACGAACTTACTTAATTTAGCACGGCGTGATGATGGGATTAAACCAGAGATTGGTG
ATATTGAACCCAATTTCTTTAATACGACCTTTACGAACTATGAAATGGTTGCCACAGAAAATGGAAAAGTTTTTCGATTT
GACAATAGGATTCACCGTGTGATAAAAACGGATAAAACCTTACTGAAGCAATTGATGACTATCTTGTTTGATAATGCCCT
GAAATATACAGACGAAGATGGTGTGATTGAATTGACAATCTCTTCAAATGATCGAAATTTGTTTTTGAAGGTTTCGGATA
ATGGTCCAGGGATTAGTACAGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCTCGGACTCGACAG
ACAGGTGGTTTTGGTTTAGGGTTGTCACTTGCAAAGCAAATTACAGAAGCTCTTAAAGGAACTATTACAGTGAAAGATAA
TAAACCGAAAGGGACTGTTTTTGAAGTAAAGATTGCGATTCGAACGGATAATAAAAAGAAAAAATAG

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

70.089

100

0.701
  ciaH Streptococcus pneumoniae D39

70.089

100

0.701
  ciaH Streptococcus pneumoniae R6

70.089

100

0.701
  ciaH Streptococcus pneumoniae TIGR4

70.089

100

0.701
  ciaH Streptococcus mutans UA159

55.708

97.768

0.545

Multiple sequence alignment