Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpP   Type   Regulator
Locus tag   DQN31_RS07325 Genome accession   NZ_LS483421
Coordinates   1445799..1446389 (-) Length   196 a.a.
NCBI ID   WP_002985850.1    Uniprot ID   A0A9X8T4H8
Organism   Streptococcus pyogenes strain NCTC10877     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1385932..1446389 1445799..1446389 within 0


Gene organization within MGE regions


Location: 1385932..1446389
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN31_RS07020 (NCTC10877_01390) - 1385932..1386984 (-) 1053 WP_010921967.1 PhoH family protein -
  DQN31_RS07025 (NCTC10877_01391) - 1387143..1388915 (-) 1773 WP_014407372.1 oleate hydratase -
  DQN31_RS07030 (NCTC10877_01392) - 1389230..1390405 (-) 1176 WP_014407371.1 LysM peptidoglycan-binding domain-containing protein -
  DQN31_RS07035 (NCTC10877_01393) - 1390561..1390776 (-) 216 WP_002985757.1 YozE family protein -
  DQN31_RS07040 (NCTC10877_01394) msrA 1390773..1391282 (-) 510 WP_002985759.1 peptide-methionine (S)-S-oxide reductase MsrA -
  DQN31_RS07045 (NCTC10877_01395) - 1391355..1392212 (-) 858 WP_011284569.1 S1 RNA-binding domain-containing protein -
  DQN31_RS07050 (NCTC10877_01396) frr 1392321..1392878 (-) 558 WP_002985763.1 ribosome recycling factor -
  DQN31_RS07055 (NCTC10877_01397) pyrH 1392907..1393635 (-) 729 WP_014411825.1 UMP kinase -
  DQN31_RS07060 (NCTC10877_01398) rplA 1393957..1394646 (-) 690 WP_002985768.1 50S ribosomal protein L1 -
  DQN31_RS07065 (NCTC10877_01399) rplK 1394752..1395177 (-) 426 WP_002990800.1 50S ribosomal protein L11 -
  DQN31_RS07070 (NCTC10877_01400) - 1395421..1395774 (+) 354 WP_041174330.1 DUF3397 domain-containing protein -
  DQN31_RS07075 (NCTC10877_01401) - 1395844..1398249 (-) 2406 WP_014407369.1 DNA translocase FtsK -
  DQN31_RS07080 (NCTC10877_01402) - 1398466..1399272 (+) 807 WP_002985776.1 peptidylprolyl isomerase -
  DQN31_RS07085 (NCTC10877_01403) - 1399420..1400274 (-) 855 WP_011017448.1 metal ABC transporter permease -
  DQN31_RS07090 (NCTC10877_01404) - 1400275..1401000 (-) 726 WP_002985780.1 metal ABC transporter ATP-binding protein -
  DQN31_RS07095 (NCTC10877_01405) - 1401064..1401996 (-) 933 WP_014407368.1 metal ABC transporter substrate-binding protein -
  DQN31_RS07100 (NCTC10877_01406) - 1402142..1402789 (+) 648 WP_002985785.1 metal-dependent transcriptional regulator -
  DQN31_RS07105 (NCTC10877_01407) - 1402886..1403227 (-) 342 WP_014407367.1 hypothetical protein -
  DQN31_RS07110 (NCTC10877_01408) - 1403378..1404073 (-) 696 WP_014407366.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
  DQN31_RS07115 (NCTC10877_01409) macP 1404093..1404344 (-) 252 WP_002993069.1 cell wall synthase accessory phosphoprotein MacP -
  DQN31_RS07120 (NCTC10877_01410) - 1404344..1404898 (-) 555 WP_014407365.1 NUDIX hydrolase -
  DQN31_RS07125 (NCTC10877_01411) glmU 1404932..1406314 (-) 1383 WP_014407364.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
  DQN31_RS07130 (NCTC10877_01412) - 1406487..1407824 (-) 1338 WP_002993065.1 MFS transporter -
  DQN31_RS07135 (NCTC10877_01413) - 1408157..1409116 (-) 960 WP_014407363.1 Gfo/Idh/MocA family protein -
  DQN31_RS07140 (NCTC10877_01414) - 1409192..1409890 (-) 699 WP_014407362.1 3-oxoacyl-ACP reductase -
  DQN31_RS07145 (NCTC10877_01415) - 1409883..1410119 (-) 237 WP_002990844.1 DUF2829 domain-containing protein -
  DQN31_RS07155 (NCTC10877_01416) - 1411162..1411818 (+) 657 WP_014407360.1 hypothetical protein -
  DQN31_RS07160 (NCTC10877_01417) spej 1412065..1412763 (+) 699 WP_014407359.1 streptococcal pyrogenic exotoxin SpeJ -
  DQN31_RS07165 (NCTC10877_01419) - 1413077..1413397 (-) 321 WP_002993880.1 hypothetical protein -
  DQN31_RS07170 (NCTC10877_01420) - 1414076..1414810 (+) 735 WP_014407357.1 hypothetical protein -
  DQN31_RS07175 (NCTC10877_01421) - 1414899..1415150 (-) 252 WP_014407356.1 hypothetical protein -
  DQN31_RS07180 (NCTC10877_01422) - 1415388..1415873 (-) 486 WP_111697162.1 hypothetical protein -
  DQN31_RS07185 (NCTC10877_01423) - 1416118..1416729 (-) 612 WP_014407354.1 hypothetical protein -
  DQN31_RS07190 (NCTC10877_01425) - 1417248..1418126 (+) 879 WP_014407353.1 ISL3 family transposase -
  DQN31_RS09235 - 1418334..1418501 (+) 168 WP_374148382.1 transposase -
  DQN31_RS07195 (NCTC10877_01426) - 1418857..1419315 (-) 459 WP_014407351.1 hypothetical protein -
  DQN31_RS07200 (NCTC10877_01427) - 1419809..1420285 (-) 477 WP_014411823.1 hypothetical protein -
  DQN31_RS07205 - 1420749..1422212 (+) 1464 Protein_1330 IS1182 family transposase -
  DQN31_RS07210 (NCTC10877_01431) - 1422328..1422858 (-) 531 WP_014407349.1 hypothetical protein -
  DQN31_RS07215 (NCTC10877_01432) - 1423306..1424058 (+) 753 WP_014411822.1 ADP-ribosyltransferase -
  DQN31_RS07225 (NCTC10877_01433) nrdE 1424263..1426443 (-) 2181 WP_014407347.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  DQN31_RS07230 (NCTC10877_01434) nrdI 1426410..1426898 (-) 489 WP_002990870.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  DQN31_RS07235 (NCTC10877_01435) nrdF 1426902..1427915 (-) 1014 WP_010921941.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  DQN31_RS07240 (NCTC10877_01436) metG 1428410..1430410 (-) 2001 WP_111697163.1 methionine--tRNA ligase -
  DQN31_RS07245 (NCTC10877_01437) - 1430650..1431357 (-) 708 WP_002985820.1 YoaK family protein -
  DQN31_RS07260 (NCTC10877_01438) scpC 1432128..1437071 (-) 4944 WP_014407343.1 CXC chemokine-degrading serine protease SpyCEP -
  DQN31_RS07265 (NCTC10877_01439) lctO 1437334..1438515 (-) 1182 WP_012560476.1 L-lactate oxidase -
  DQN31_RS07275 (NCTC10877_01440) - 1438749..1439576 (+) 828 WP_002990895.1 exodeoxyribonuclease III -
  DQN31_RS07280 (NCTC10877_01441) - 1439650..1440006 (-) 357 WP_014407341.1 arsenate reductase family protein -
  DQN31_RS07285 (NCTC10877_01442) - 1440307..1440936 (+) 630 WP_014407340.1 copper homeostasis protein CutC -
  DQN31_RS07290 (NCTC10877_01443) - 1440983..1441375 (-) 393 WP_002985833.1 DUF5684 domain-containing protein -
  DQN31_RS07295 (NCTC10877_01444) rsmI 1441402..1442265 (-) 864 WP_014407339.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
  DQN31_RS07300 (NCTC10877_01445) yabA 1442270..1442593 (-) 324 WP_002985838.1 DNA replication initiation control protein YabA -
  DQN31_RS07305 (NCTC10877_01446) - 1442998..1443237 (-) 240 WP_014407337.1 PSP1 C-terminal domain-containing protein -
  DQN31_RS07310 (NCTC10877_01447) - 1443256..1444131 (-) 876 WP_002985844.1 DNA polymerase III subunit delta' -
  DQN31_RS07315 (NCTC10877_01448) tmk 1444149..1444784 (-) 636 WP_041174327.1 dTMP kinase -
  DQN31_RS07320 (NCTC10877_01449) - 1445033..1445308 (-) 276 WP_002985847.1 YlbG family protein -
  DQN31_RS07325 (NCTC10877_01450) clpP 1445799..1446389 (-) 591 WP_002985850.1 ATP-dependent Clp protease proteolytic subunit Regulator

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 21648.88 Da        Isoelectric Point: 5.2834

>NTDB_id=1141070 DQN31_RS07325 WP_002985850.1 1445799..1446389(-) (clpP) [Streptococcus pyogenes strain NCTC10877]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGK
TIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK

Nucleotide


Download         Length: 591 bp        

>NTDB_id=1141070 DQN31_RS07325 WP_002985850.1 1445799..1446389(-) (clpP) [Streptococcus pyogenes strain NCTC10877]
ATGATTCCTGTTGTTATTGAACAAACTAGTCGTGGAGAACGTTCTTATGACATTTATTCACGTTTATTAAAAGACCGTAT
TATCATGTTAACAGGGCCTGTCGAAGACAACATGGCCAACTCTGTCATAGCGCAGCTCTTATTCCTTGACGCGCAAGACA
ACACGAAAGATATCTACCTATATGTCAACACACCAGGTGGCTCTGTCTCAGCAGGCTTGGCTATTGTCGATACCATGAAC
TTTATCAAGGCTGATGTGCAAACTATTGTCATGGGTATGGCAGCTTCTATGGGGACAGTCATTGCTTCATCAGGAACAAA
AGGCAAACGCTTTATGTTACCAAATGCAGAGTATATGATCCACCAGCCAATGGGTGGCACAGGCGGTGGCACGCAACAAA
CGGATATGGCTATCGCAGCAGAACATCTCTTAAAAACACGTCACCGTTTAGAAAAAATCTTAGCGCAAAATGCTGGAAAA
ACGATTAAACAAATCCATAAAGATGCTGAGCGTGATTATTGGATGAGTGCTGAAGAAACCTTGGCTTACGGTTTCATTGA
TGAAATCATGGAAAACAACGAACTAAAATAA

Domains

Predicted by InterproScan.

Clp protease (CLP_protease)

(11-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pyogenes MGAS315

100

100

1
  clpP Streptococcus pyogenes JRS4

100

100

1
  clpP Streptococcus mutans UA159

90.816

100

0.908
  clpP Streptococcus pneumoniae Rx1

90.769

99.49

0.903
  clpP Streptococcus pneumoniae D39

90.769

99.49

0.903
  clpP Streptococcus pneumoniae R6

90.769

99.49

0.903
  clpP Streptococcus pneumoniae TIGR4

90.769

99.49

0.903
  clpP Streptococcus thermophilus LMG 18311

89.796

100

0.898
  clpP Streptococcus thermophilus LMD-9

89.796

100

0.898
  clpP Lactococcus lactis subsp. lactis strain DGCC12653

86.224

100

0.862
  clpP Lactococcus lactis subsp. cremoris KW2

85.714

100

0.857
  clpP Bacillus subtilis subsp. subtilis str. 168

57.143

100

0.571
  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

56.995

98.469

0.561

Multiple sequence alignment