Detailed information NTG0114079

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: T303_RS02505
• Genome accession: NZ_CP006819
• Coordinates: 444857..445756 (+)
• Length: 299 a.a.
• NCBI ID: WP_014607953.1
• Uniprot ID: A0AAN1ZWJ0
• Organism: Streptococcus thermophilus ASCC 1275
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 439857..450756

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
T303_RS02485 (T303_02530)	trkA	440994..442343 (-)	1350	WP_024704181.1	Trk system potassium transporter TrkA	-
T303_RS02490 (T303_02535)	-	442632..443141 (+)	510	WP_024704182.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
T303_RS02495 (T303_02540)	-	443452..444009 (+)	558	WP_024704183.1	ECF transporter S component	-
T303_RS02500 (T303_02545)	-	444012..444662 (+)	651	WP_011225447.1	phosphatase PAP2 family protein	-
T303_RS02505 (T303_02550)	comR	444857..445756 (+)	900	WP_014607953.1	helix-turn-helix domain-containing protein	Regulator
T303_RS11365	-	445994..446425 (+)	432	Protein_438	cysteine peptidase family C39 domain-containing protein	-
T303_RS11370	-	446455..447171 (+)	717	Protein_439	ABC transporter transmembrane domain-containing protein	-
T303_RS11375	comA	447193..447402 (+)	210	WP_002946147.1	hypothetical protein	Regulator
T303_RS02530	-	447457..448025 (+)	569	Protein_441	ATP-binding cassette domain-containing protein	-
T303_RS02535 (T303_02560)	-	448133..448465 (+)	333	WP_024704184.1	DUF805 domain-containing protein	-
T303_RS11380	-	448611..449090 (-)	480	WP_224107489.1	DUF4153 domain-containing protein	-
T303_RS11385 (T303_02570)	-	449532..449903 (-)	372	WP_224107488.1	hypothetical protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35289.70 Da
• Isoelectric Point: 5.0061

>NTDB_id=114079 T303_RS02505 WP_014607953.1 444857..445756(+) (comR) [Streptococcus thermophilus ASCC 1275]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIENS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=114079 T303_RS02505 WP_014607953.1 444857..445756(+) (comR) [Streptococcus thermophilus ASCC 1275]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAACTCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (11-66)

• ComR tetratricopeptide (ComR_TPR) (75-292)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	99.666	100	0.997
comR	Streptococcus thermophilus LMD-9	98.997	100	0.99
comR	Streptococcus salivarius strain HSISS4	94.983	100	0.95
comR	Streptococcus salivarius SK126	94.314	100	0.943
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	41.806	100	0.418