Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQN21_RS06345 Genome accession   NZ_LS483409
Coordinates   1250014..1250688 (-) Length   224 a.a.
NCBI ID   WP_009854247.1    Uniprot ID   A0A139MP14
Organism   Streptococcus gallolyticus strain NCTC13773     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1245014..1255688
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN21_RS06320 (NCTC13773_01282) deoC 1245442..1246104 (-) 663 WP_074580979.1 deoxyribose-phosphate aldolase -
  DQN21_RS06325 (NCTC13773_01283) - 1246595..1247188 (-) 594 WP_012961986.1 class I SAM-dependent methyltransferase -
  DQN21_RS06330 (NCTC13773_01284) coaA 1247302..1248222 (+) 921 WP_009854245.1 type I pantothenate kinase -
  DQN21_RS06335 (NCTC13773_01285) rpsT 1248297..1248548 (+) 252 WP_003064878.1 30S ribosomal protein S20 -
  DQN21_RS06340 (NCTC13773_01286) ciaH 1248684..1250024 (-) 1341 WP_009854246.1 sensor histidine kinase Regulator
  DQN21_RS06345 (NCTC13773_01287) ciaR 1250014..1250688 (-) 675 WP_009854247.1 response regulator transcription factor Regulator
  DQN21_RS06350 (NCTC13773_01288) - 1250886..1253429 (-) 2544 WP_077496889.1 M1 family metallopeptidase -
  DQN21_RS06355 (NCTC13773_01289) phoU 1253652..1254305 (-) 654 WP_009854249.1 phosphate signaling complex protein PhoU -
  DQN21_RS06360 (NCTC13773_01290) pstB 1254336..1255094 (-) 759 WP_009854250.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25465.13 Da        Isoelectric Point: 4.3102

>NTDB_id=1140565 DQN21_RS06345 WP_009854247.1 1250014..1250688(-) (ciaR) [Streptococcus gallolyticus strain NCTC13773]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKYNDNTLSYEELTVDTSTNTTIANGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFAKNLQTLRSVGYILKNAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1140565 DQN21_RS06345 WP_009854247.1 1250014..1250688(-) (ciaR) [Streptococcus gallolyticus strain NCTC13773]
ATGATTAAGATATTATTAGTAGAAGATGATTTGAGTCTATCTAATTCCATTTTTGATTTTTTAGATGATTTTGCAGATGT
TATGCAGGTATTTGACGGCGAAGAAGGTTTGTACGAAGCTGAAAGTGGCGTATATGACCTTATTTTGCTTGACTTGATGT
TACCTGAAAAAGATGGTTTCCAAGTGCTTAAAGAGTTACGAGAAAAAGGTGTGTCAACACCAGTACTTATTATGACTGCC
AAAGAAAGCCTTGATGATAAGGGACATGGTTTCGAGTTGGGAGCAGATGATTACCTTACTAAACCATTTTACCTTGAAGA
GCTAAAAATGCGTATTCAAGCTCTTTTAAAACGTTCGGGTAAATACAACGACAATACCTTATCTTATGAAGAATTAACCG
TTGACACTTCTACCAATACAACAATAGCTAACGGTAAAGAAGTCGAGCTGCTTGGTAAAGAATTTGATTTGTTGGTTTAT
TTCTTACAAAATCAAAATGTTATTTTACCAAAATCACAAATTTTTGACCGTATTTGGGGCTTTGATAGTGATACAACGAT
TTCGGTTGTTGAAGTTTACGTTTCAAAAATTCGAAAAAAACTCAAAGGCACTACCTTTGCCAAAAATCTTCAAACCCTAC
GGAGTGTAGGTTATATTCTGAAAAATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A139MP14

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

92.825

99.554

0.924
  ciaR Streptococcus pneumoniae Rx1

87.054

100

0.871
  ciaR Streptococcus pneumoniae D39

87.054

100

0.871
  ciaR Streptococcus pneumoniae R6

87.054

100

0.871
  ciaR Streptococcus pneumoniae TIGR4

87.054

100

0.871
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.938

100

0.393
  vicR Streptococcus mutans UA159

35.47

100

0.371
  micA Streptococcus pneumoniae Cp1015

35.622

100

0.371

Multiple sequence alignment