Detailed information NTG1140154

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: DQM95_RS02695
• Genome accession: NZ_LS483397
• Coordinates: 476024..476614 (+)
• Length: 196 a.a.
• NCBI ID: WP_012657964.1
• Uniprot ID: A0A2X4GXW6
• Organism: Streptococcus uberis strain NCTC3858
• Function: degradation of ComX; require for competence development (at the early growth phase); repress competence development (at the mid-logarithmic growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 471024..481614

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM95_RS02680 (NCTC3858_00546)	-	471931..473568 (+)	1638	WP_012657961.1	polysaccharide biosynthesis protein	-
DQM95_RS02685 (NCTC3858_00547)	-	473666..474829 (+)	1164	WP_012657962.1	MalY/PatB family protein	-
DQM95_RS02690 (NCTC3858_00548)	upp	474921..475550 (+)	630	WP_012657963.1	uracil phosphoribosyltransferase	-
DQM95_RS02695 (NCTC3858_00549)	clpP	476024..476614 (+)	591	WP_012657964.1	ATP-dependent Clp protease proteolytic subunit ClpP	Regulator
DQM95_RS02700 (NCTC3858_00550)	-	476857..477303 (+)	447	WP_111685930.1	YlbF family regulator	-
DQM95_RS02705 (NCTC3858_00551)	-	477303..477560 (+)	258	WP_037592428.1	YlbG family protein	-
DQM95_RS02710 (NCTC3858_00552)	-	477699..478871 (+)	1173	WP_037592425.1	ABC transporter substrate-binding protein	-
DQM95_RS02715 (NCTC3858_00553)	-	478912..479781 (+)	870	WP_037592423.1	branched-chain amino acid ABC transporter permease	-
DQM95_RS02720 (NCTC3858_00554)	-	479784..480737 (+)	954	WP_037592420.1	branched-chain amino acid ABC transporter permease	-
DQM95_RS02725 (NCTC3858_00555)	-	480737..481501 (+)	765	WP_012657970.1	ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 196 a.a.
• Molecular weight: 21761.03 Da
• Isoelectric Point: 5.0494

>NTDB_id=1140154 DQM95_RS02695 WP_012657964.1 476024..476614(+) (clpP) [Streptococcus uberis strain NCTC3858]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAEYLIHQPMGGTGSGTQQTDMAIVAEQLLKTRKRLEKILSDNSGK
TIKQIHKDAERDYWMDAKETLEYGFIDAIMENNELK

Nucleotide

• Length: 591 bp

>NTDB_id=1140154 DQM95_RS02695 WP_012657964.1 476024..476614(+) (clpP) [Streptococcus uberis strain NCTC3858]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGGGAACGTTCTTATGATATTTACTCACGTTTACTGAAAGATCGTAT
TATCATGTTAACTGGTCCTGTTGAGGATAATATGGCAAATTCCATCATTGCTCAATTGCTCTTTTTAGATGCACAAGATA
ATACAAAAGATATTTATTTATACGTCAATACACCTGGCGGTTCTGTTTCAGCTGGACTTGCCATTGTTGATACAATGAAC
TTTATTAAATCTGATGTTCAAACCATTGTTATGGGTATGGCTGCTTCTATGGGTACCATTATTGCCTCATCAGGTACAAA
AGGGAAACGTTTCATGTTACCAAATGCAGAATACCTCATTCACCAACCAATGGGTGGCACAGGAAGTGGCACACAACAAA
CCGATATGGCCATTGTTGCCGAACAACTTTTGAAAACACGTAAACGCCTTGAAAAAATCCTTTCTGATAACTCTGGAAAA
ACCATTAAACAAATTCATAAAGATGCCGAACGTGATTATTGGATGGATGCAAAAGAAACCTTAGAATATGGGTTCATTGA
TGCCATCATGGAGAACAACGAACTAAAATAA

Domains

Predicted by InterproScan.

• Clp protease (CLP_protease) (11-192)

3D structure

• AlphaFold DB: A0A2X4GXW6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Streptococcus mutans UA159	94.898	100	0.949
clpP	Streptococcus pyogenes JRS4	92.347	100	0.923
clpP	Streptococcus pyogenes MGAS315	92.347	100	0.923
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	91.327	100	0.913
clpP	Lactococcus lactis subsp. cremoris KW2	90.816	100	0.908
clpP	Streptococcus thermophilus LMD-9	89.286	100	0.893
clpP	Streptococcus thermophilus LMG 18311	89.286	100	0.893
clpP	Streptococcus pneumoniae Rx1	86.667	99.49	0.862
clpP	Streptococcus pneumoniae D39	86.667	99.49	0.862
clpP	Streptococcus pneumoniae R6	86.667	99.49	0.862
clpP	Streptococcus pneumoniae TIGR4	86.667	99.49	0.862
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	55.959	98.469	0.551
clpP	Bacillus subtilis subsp. subtilis str. 168	55.102	100	0.551