Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   DQM63_RS07580 Genome accession   NZ_LS483385
Coordinates   1534170..1534871 (-) Length   233 a.a.
NCBI ID   WP_002894937.1    Uniprot ID   A0A0B7GM19
Organism   Streptococcus sanguinis strain NCTC7863     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1529170..1539871
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM63_RS07560 (NCTC7863_01490) rnc 1530747..1531445 (-) 699 WP_002913383.1 ribonuclease III -
  DQM63_RS07565 (NCTC7863_01491) - 1531567..1531926 (-) 360 WP_002906095.1 YbaN family protein -
  DQM63_RS07570 (NCTC7863_01492) vicX 1532018..1532818 (-) 801 WP_002913382.1 MBL fold metallo-hydrolase Regulator
  DQM63_RS07575 (NCTC7863_01493) micB 1532828..1534177 (-) 1350 WP_002899938.1 cell wall metabolism sensor histidine kinase VicK Regulator
  DQM63_RS07580 (NCTC7863_01494) micA 1534170..1534871 (-) 702 WP_002894937.1 response regulator YycF Regulator
  DQM63_RS07585 (NCTC7863_01495) - 1535208..1535969 (+) 762 WP_002913381.1 amino acid ABC transporter ATP-binding protein -
  DQM63_RS07590 (NCTC7863_01496) - 1535984..1536796 (+) 813 WP_002913380.1 transporter substrate-binding domain-containing protein -
  DQM63_RS07595 (NCTC7863_01497) - 1536809..1537489 (+) 681 WP_002913378.1 amino acid ABC transporter permease -
  DQM63_RS07600 (NCTC7863_01498) - 1537500..1538159 (+) 660 WP_002906089.1 amino acid ABC transporter permease -
  DQM63_RS07605 (NCTC7863_01499) - 1538268..1538666 (+) 399 WP_002913375.1 hypothetical protein -

Sequence

Protein


Download         Length: 233 a.a.        Molecular weight: 26735.63 Da        Isoelectric Point: 4.7458

>NTDB_id=1139638 DQM63_RS07580 WP_002894937.1 1534170..1534871(-) (micA) [Streptococcus sanguinis strain NCTC7863]
MKKILVVDDEKPISDIIKFNMAKEGYEVLTAFDGKEALEMFEAEQPDILILDLMLPEVDGLEVARTIRKTSNVPIIVLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELQARVKALLRRADLVVENQVEESGPNELTIGELQILPDAFVAKKHGKELELTH
REFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide


Download         Length: 702 bp        

>NTDB_id=1139638 DQM63_RS07580 WP_002894937.1 1534170..1534871(-) (micA) [Streptococcus sanguinis strain NCTC7863]
ATGAAGAAAATATTAGTTGTAGATGATGAGAAACCAATCTCAGATATTATTAAGTTTAATATGGCCAAGGAAGGCTATGA
GGTTTTGACTGCCTTTGATGGCAAGGAAGCTTTGGAAATGTTTGAAGCAGAACAGCCGGACATCTTGATTCTGGACTTGA
TGCTGCCAGAAGTGGACGGACTGGAAGTTGCTCGGACTATTCGCAAGACCAGCAATGTTCCGATTATTGTATTGTCTGCT
AAGGACAGTGAGTTTGACAAGGTTATCGGCCTTGAAATTGGTGCTGATGACTATGTGACCAAGCCTTTCTCAAATCGTGA
GCTGCAGGCGCGTGTTAAGGCACTTCTTCGTCGGGCAGACCTTGTTGTGGAAAACCAAGTAGAAGAAAGTGGCCCGAACG
AGTTGACCATTGGAGAACTGCAGATTTTGCCAGATGCTTTTGTTGCTAAGAAGCATGGCAAGGAGCTGGAGCTGACCCAC
CGCGAGTTTGAACTTCTTCATCATTTGGCGACACATATCGGTCAGGTGATGACACGTGAGCACTTGCTGGAAACAGTATG
GGGCTATGACTATTTTGGCGATGTCCGTACAGTGGATGTGACCATTCGCCGCCTGCGTGAAAAGATTGAAGATACGCCAA
GCCGACCTGAGTATATCTTGACTCGCCGCGGAGTTGGCTACTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-228)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7GM19

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

82.833

100

0.828
  vicR Streptococcus mutans UA159

80.426

100

0.811
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.231

98.283

0.425
  covR Streptococcus salivarius strain HSISS4

42.174

98.712

0.416
  scnR Streptococcus mutans UA159

36.957

98.712

0.365

Multiple sequence alignment