Detailed information NTG1139040

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: DQM66_RS04535
• Genome accession: NZ_LS483374
• Coordinates: 857954..858604 (+)
• Length: 216 a.a.
• NCBI ID: WP_000387330.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain NCTC7466
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 852954..863604

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM66_RS04490 (NCTC7466_00866)	-	853437..853652 (+)	216	WP_001232082.1	YozE family protein	-
DQM66_RS04495 (NCTC7466_00867)	-	853738..854706 (+)	969	WP_000658183.1	PhoH family protein	-
DQM66_RS04505 (NCTC7466_00868)	-	854899..855399 (+)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
DQM66_RS04510 (NCTC7466_00869)	-	855402..855728 (+)	327	Protein_851	TfoX/Sxy family protein	-
DQM66_RS11410	ald	856029..857140 (-)	1112	Protein_852	alanine dehydrogenase	-
DQM66_RS04530 (NCTC7466_00872)	-	857317..857886 (+)	570	WP_000443899.1	GNAT family N-acetyltransferase	-
DQM66_RS04535 (NCTC7466_00873)	comEA/celA/cilE	857954..858604 (+)	651	WP_000387330.1	ComEA family DNA-binding protein	Machinery gene
DQM66_RS04540 (NCTC7466_00874)	comEC/celB	858588..860828 (+)	2241	WP_000942407.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
DQM66_RS04545	-	861007..861195 (+)	189	WP_010976492.1	hypothetical protein	-
DQM66_RS04550 (NCTC7466_00875)	-	861227..861814 (+)	588	Protein_857	ATP-binding cassette domain-containing protein	-
DQM66_RS04555 (NCTC7466_00876)	-	861818..862999 (+)	1182	WP_000655958.1	ABC transporter permease	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23229.65 Da
• Isoelectric Point: 5.5171

>NTDB_id=1139040 DQM66_RS04535 WP_000387330.1 857954..858604(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain NCTC7466]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGLGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=1139040 DQM66_RS04535 WP_000387330.1 857954..858604(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain NCTC7466]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAACCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTCGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAAAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGCCAACAGACTGGTTTGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• Helix-hairpin-helix motif (HHH_3) (151-214)

• SLBB domain (SLBB) (76-126)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	100	100	1
comEA/celA/cilE	Streptococcus pneumoniae D39	100	100	1
comEA/celA/cilE	Streptococcus pneumoniae R6	100	100	1
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.222	100	0.972
comEA/celA/cilE	Streptococcus mitis NCTC 12261	96.296	100	0.963
comEA/celA/cilE	Streptococcus mitis SK321	90.278	100	0.903
comEA	Lactococcus lactis subsp. cremoris KW2	43.172	100	0.454
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366
comEA	Latilactobacillus sakei subsp. sakei 23K	33.476	100	0.361