Detailed information NTG1138665

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: DQM55_RS04150
• Genome accession: NZ_LS483364
• Coordinates: 789083..789784 (+)
• Length: 233 a.a.
• NCBI ID: WP_002894937.1
• Uniprot ID: A0A0B7GM19
• Organism: Streptococcus sanguinis strain NCTC11086
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 784083..794784

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM55_RS04115 (NCTC11086_00813)	-	784428..784790 (-)	363	WP_111675559.1	MerR family transcriptional regulator	-
DQM55_RS04120 (NCTC11086_00814)	-	784868..785245 (+)	378	WP_002899930.1	carboxymuconolactone decarboxylase family protein	-
DQM55_RS04125 (NCTC11086_00815)	-	785332..785682 (-)	351	WP_111675560.1	hypothetical protein	-
DQM55_RS04130 (NCTC11086_00816)	-	785791..786450 (-)	660	WP_049547961.1	amino acid ABC transporter permease	-
DQM55_RS04135 (NCTC11086_00817)	-	786461..787141 (-)	681	WP_111675561.1	amino acid ABC transporter permease	-
DQM55_RS04140 (NCTC11086_00818)	-	787154..787966 (-)	813	WP_111675562.1	transporter substrate-binding domain-containing protein	-
DQM55_RS04145 (NCTC11086_00819)	-	787981..788742 (-)	762	WP_111675563.1	amino acid ABC transporter ATP-binding protein	-
DQM55_RS04150 (NCTC11086_00820)	micA	789083..789784 (+)	702	WP_002894937.1	response regulator YycF	Regulator
DQM55_RS04155 (NCTC11086_00821)	micB	789777..791126 (+)	1350	WP_002899938.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DQM55_RS04160 (NCTC11086_00822)	vicX	791136..791936 (+)	801	WP_111675564.1	MBL fold metallo-hydrolase	Regulator
DQM55_RS04165 (NCTC11086_00823)	-	792028..792387 (+)	360	WP_002894940.1	DUF454 family protein	-
DQM55_RS04170 (NCTC11086_00824)	rnc	792509..793207 (+)	699	WP_111675565.1	ribonuclease III	-

Sequence

Protein

• Length: 233 a.a.
• Molecular weight: 26735.63 Da
• Isoelectric Point: 4.7458

>NTDB_id=1138665 DQM55_RS04150 WP_002894937.1 789083..789784(+) (micA) [Streptococcus sanguinis strain NCTC11086]
MKKILVVDDEKPISDIIKFNMAKEGYEVLTAFDGKEALEMFEAEQPDILILDLMLPEVDGLEVARTIRKTSNVPIIVLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELQARVKALLRRADLVVENQVEESGPNELTIGELQILPDAFVAKKHGKELELTH
REFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide

• Length: 702 bp

>NTDB_id=1138665 DQM55_RS04150 WP_002894937.1 789083..789784(+) (micA) [Streptococcus sanguinis strain NCTC11086]
ATGAAGAAAATATTAGTTGTAGATGATGAGAAACCAATCTCAGATATTATTAAGTTTAATATGGCTAAAGAAGGCTATGA
GGTTTTGACTGCCTTTGATGGTAAGGAAGCTTTGGAAATGTTTGAAGCAGAACAGCCAGATATCTTGATTCTGGACTTGA
TGCTGCCAGAAGTGGATGGACTGGAAGTTGCTAGGACTATTCGCAAGACCAGCAATGTGCCGATTATTGTATTGTCCGCT
AAGGACAGTGAGTTTGACAAGGTTATCGGCCTTGAAATAGGTGCAGATGACTATGTGACCAAGCCTTTCTCAAATCGTGA
GCTGCAGGCGCGTGTCAAGGCACTTCTTCGTCGGGCAGACCTTGTTGTGGAAAATCAAGTAGAAGAAAGTGGCCCGAACG
AGTTGACCATTGGAGAACTGCAGATTTTGCCAGATGCTTTTGTTGCTAAGAAGCATGGCAAGGAGCTGGAGCTGACCCAC
CGTGAGTTTGAACTGCTTCACCATTTGGCGACACATATCGGTCAAGTGATGACACGTGAGCACTTGCTGGAAACAGTATG
GGGCTATGACTATTTTGGCGATGTCCGTACAGTGGATGTGACCATTCGCCGCCTGCGTGAAAAGATTGAAGATACGCCAA
GCCGACCTGAGTATATCTTGACTCGCCGCGGAGTTGGCTATTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-228)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A0B7GM19

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	82.833	100	0.828
vicR	Streptococcus mutans UA159	80.426	100	0.811
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.231	98.283	0.425
covR	Streptococcus salivarius strain HSISS4	42.174	98.712	0.416
scnR	Streptococcus mutans UA159	36.957	98.712	0.365