Detailed information NTG1137733

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DQM73_RS12265
• Genome accession: NZ_LS483346
• Coordinates: 2447317..2448489 (+)
• Length: 390 a.a.
• NCBI ID: WP_002927420.1
• Uniprot ID: -
• Organism: Streptococcus sanguinis strain NCTC11085
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2442317..2453489

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM73_RS12225	-	2442459..2443810 (+)	1352	WP_111681466.1	IS3 family transposase	-
DQM73_RS12240 (NCTC11085_02410)	comE	2444097..2444861 (-)	765	WP_002899424.1	competence system response regulator transcription factor ComE	Regulator
DQM73_RS12245 (NCTC11085_02411)	comD	2444867..2446201 (-)	1335	WP_002927417.1	competence system sensor histidine kinase ComD	-
DQM73_RS12250 (NCTC11085_02412)	-	2446229..2446336 (-)	108	WP_002894290.1	hypothetical protein	-
DQM73_RS12260 (NCTC11085_02414)	rlmH	2446634..2447113 (-)	480	WP_002927418.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQM73_RS12265 (NCTC11085_02415)	htrA	2447317..2448489 (+)	1173	WP_002927420.1	S1C family serine protease	Regulator
DQM73_RS12270 (NCTC11085_02416)	spo0J	2448553..2449314 (+)	762	WP_002927422.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 390 a.a.
• Molecular weight: 40884.68 Da
• Isoelectric Point: 4.8344

>NTDB_id=1137733 DQM73_RS12265 WP_002927420.1 2447317..2448489(+) (htrA) [Streptococcus sanguinis strain NCTC11085]
MKNSSNAIKKALLLFAVLIVGFIGGSLGNYVTTLVTSRVKMNGNSTTSVTTSYKNSTDISEAVKKVQNAVVSVITYAESS
SSVINDESSNDESQISSEGSGVIYKKDGKSAYLVTNTHVLNGSTNVDILLADGNKVPGEVVGSDVYSDISVVKISSEKVT
DVAEFGDSKSLTVGETAIAIGSPLGTEYANSVTQGIISSLGRNVTLQSENGENISTTALQTDAAINPGNSGGPLINIQGQ
VIGITSSKISTNGQTSVEGMGFAIPSNDVVNIINQLEKNGTVTRPALGIQMMDLSNLTTSDFSKLNLPSSVKSGVLVRSV
QQGMPADGKLQKNDVITKVDNTDVESTSDLQSALYKHSIGDEVEITYYRDGKSQTVKIKLTKSTKELSSN

Nucleotide

• Length: 1173 bp

>NTDB_id=1137733 DQM73_RS12265 WP_002927420.1 2447317..2448489(+) (htrA) [Streptococcus sanguinis strain NCTC11085]
ATGAAAAACTCTTCAAATGCCATCAAAAAGGCTTTATTGCTTTTTGCAGTGTTAATTGTAGGTTTTATCGGCGGAAGTTT
AGGGAATTATGTTACTACATTAGTAACTTCACGTGTAAAAATGAATGGAAATTCAACAACCAGTGTAACTACTTCATATA
AAAACTCTACAGACATTTCAGAAGCTGTGAAAAAGGTTCAAAATGCGGTTGTTTCAGTAATTACTTATGCTGAATCTTCT
AGCAGCGTTATCAATGATGAATCTTCCAACGATGAATCACAAATCTCCAGTGAAGGTTCTGGCGTAATTTATAAAAAAGA
CGGAAAATCAGCCTATCTAGTAACCAACACCCACGTTCTTAACGGATCAACCAATGTAGATATCTTGCTAGCTGATGGAA
ACAAGGTTCCAGGTGAAGTAGTTGGATCAGATGTTTATTCAGATATCTCTGTCGTTAAAATTAGCTCTGAAAAAGTGACT
GATGTCGCTGAATTTGGAGATTCTAAATCTCTGACAGTTGGTGAGACAGCTATCGCTATCGGAAGTCCTCTTGGAACAGA
ATATGCTAACTCTGTCACACAAGGAATTATTTCTAGTTTAGGCAGAAACGTTACGTTACAATCTGAAAATGGTGAAAATA
TTTCAACAACTGCACTGCAAACAGATGCTGCAATCAATCCTGGTAACTCTGGCGGTCCGTTGATTAACATACAAGGACAA
GTTATTGGGATTACTTCAAGTAAAATCTCAACAAATGGCCAAACCTCTGTTGAAGGGATGGGATTTGCGATTCCATCTAA
TGATGTCGTAAATATTATCAATCAACTTGAGAAAAATGGAACAGTCACACGTCCTGCTTTAGGAATTCAAATGATGGATT
TATCTAATCTGACAACTTCTGATTTTTCTAAATTAAATCTTCCTTCTTCAGTGAAATCAGGTGTTCTTGTTCGTTCTGTT
CAGCAAGGAATGCCTGCTGATGGCAAGCTTCAAAAAAATGATGTCATTACAAAAGTAGATAACACAGATGTGGAATCCAC
TAGTGATTTACAATCTGCTCTCTACAAGCATAGTATTGGAGATGAAGTAGAAATTACTTATTATCGAGATGGTAAATCTC
AAACAGTCAAAATCAAACTCACTAAATCAACAAAAGAGTTAAGCTCAAATTAA

Domains

Predicted by InterproScan.

• Peptidase family M50 (Peptidase_M50) (231-385)

• PDZ domain (PDZ_2) (285-380)

• Trypsin-like peptidase domain (Trypsin_2) (99-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	67.929	100	0.69
htrA	Streptococcus mitis NCTC 12261	64.377	100	0.649
htrA	Streptococcus pneumoniae Rx1	64.377	100	0.649
htrA	Streptococcus pneumoniae D39	64.377	100	0.649
htrA	Streptococcus pneumoniae R6	64.377	100	0.649
htrA	Streptococcus pneumoniae TIGR4	64.377	100	0.649
htrA	Streptococcus mutans UA159	54.684	100	0.554