Detailed information NTG1137709

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: DQM73_RS08100
• Genome accession: NZ_LS483346
• Coordinates: 1643518..1644219 (-)
• Length: 233 a.a.
• NCBI ID: WP_002894937.1
• Uniprot ID: A0A0B7GM19
• Organism: Streptococcus sanguinis strain NCTC11085
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1638518..1649219

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM73_RS08075 (NCTC11085_01584)	rnc	1638868..1639566 (-)	699	WP_002899941.1	ribonuclease III	-
DQM73_RS08080 (NCTC11085_01585)	-	1639689..1640048 (-)	360	WP_032908117.1	YbaN family protein	-
DQM73_RS08085 (NCTC11085_01586)	-	1640152..1641093 (-)	942	WP_002923960.1	hypothetical protein	-
DQM73_RS08090 (NCTC11085_01587)	vicX	1641366..1642166 (-)	801	WP_002923959.1	MBL fold metallo-hydrolase	Regulator
DQM73_RS08095 (NCTC11085_01588)	micB	1642176..1643525 (-)	1350	WP_002899938.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DQM73_RS08100 (NCTC11085_01589)	micA	1643518..1644219 (-)	702	WP_002894937.1	response regulator YycF	Regulator
DQM73_RS08105 (NCTC11085_01590)	-	1644559..1645320 (+)	762	WP_002920730.1	amino acid ABC transporter ATP-binding protein	-
DQM73_RS08110 (NCTC11085_01591)	-	1645335..1646147 (+)	813	WP_002923957.1	transporter substrate-binding domain-containing protein	-
DQM73_RS08115 (NCTC11085_01592)	-	1646160..1646840 (+)	681	WP_002906090.1	amino acid ABC transporter permease	-
DQM73_RS08120 (NCTC11085_01593)	-	1646851..1647510 (+)	660	WP_002923955.1	amino acid ABC transporter permease	-
DQM73_RS08125 (NCTC11085_01594)	-	1647619..1648017 (+)	399	WP_002923953.1	hypothetical protein	-

Sequence

Protein

• Length: 233 a.a.
• Molecular weight: 26735.63 Da
• Isoelectric Point: 4.7458

>NTDB_id=1137709 DQM73_RS08100 WP_002894937.1 1643518..1644219(-) (micA) [Streptococcus sanguinis strain NCTC11085]
MKKILVVDDEKPISDIIKFNMAKEGYEVLTAFDGKEALEMFEAEQPDILILDLMLPEVDGLEVARTIRKTSNVPIIVLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELQARVKALLRRADLVVENQVEESGPNELTIGELQILPDAFVAKKHGKELELTH
REFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide

• Length: 702 bp

>NTDB_id=1137709 DQM73_RS08100 WP_002894937.1 1643518..1644219(-) (micA) [Streptococcus sanguinis strain NCTC11085]
ATGAAGAAAATATTAGTTGTAGATGATGAGAAACCAATCTCAGATATTATTAAGTTTAATATGGCCAAGGAAGGCTATGA
GGTTTTGACTGCTTTTGATGGTAAGGAAGCCTTGGAAATGTTTGAGGCAGAACAGCCAGACATCTTGATTCTGGACTTGA
TGTTGCCAGAAGTGGACGGACTGGAAGTTGCTAGGACTATTCGCAAGACCAGCAATGTTCCGATTATTGTATTGTCTGCT
AAGGACAGTGAGTTTGACAAGGTTATCGGCCTTGAAATCGGTGCAGATGACTATGTGACCAAGCCTTTCTCAAATCGTGA
GCTGCAGGCGCGTGTCAAGGCACTTCTTCGTCGGGCAGACCTTGTTGTGGAAAATCAAGTAGAAGAAAGTGGCCCGAACG
AGTTGACCATTGGGGAACTGCAGATTTTGCCAGATGCTTTTGTAGCTAAGAAGCATGGCAAGGAGCTGGAGCTGACCCAC
CGTGAGTTTGAACTGCTTCACCATTTGGCGACACATATCGGTCAGGTCATGACACGTGAGCACTTGCTGGAAACAGTATG
GGGCTATGACTATTTTGGCGATGTCCGTACAGTGGATGTGACCATTCGCCGCCTGCGTGAAAAGATTGAAGATACGCCAA
GCCGACCTGAGTATATCTTGACTCGCCGCGGAGTTGGCTACTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-228)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A0B7GM19

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	82.833	100	0.828
vicR	Streptococcus mutans UA159	80.426	100	0.811
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.231	98.283	0.425
covR	Streptococcus salivarius strain HSISS4	42.174	98.712	0.416
scnR	Streptococcus mutans UA159	36.957	98.712	0.365