Detailed information NTG1131526

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: H1W74_RS05315
• Genome accession: NZ_LR822031
• Coordinates: 1018781..1019488 (-)
• Length: 235 a.a.
• NCBI ID: WP_011226084.1
• Uniprot ID: A0A060BQ44
• Organism: Streptococcus thermophilus isolate STH_CIRM_1047
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1013781..1024488

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W74_RS05290 (STHERMO_1208)	yidA	1014132..1014941 (+)	810	WP_011226081.1	sugar-phosphatase	-
H1W74_RS05295 (STHERMO_1209)	-	1014943..1016157 (+)	1215	WP_004197368.1	aminoacyltransferase	-
H1W74_RS05300	-	1016209..1016570 (-)	362	Protein_998	YbaN family protein	-
H1W74_RS05305 (STHERMO_1210)	vicX	1016630..1017442 (-)	813	WP_011681204.1	MBL fold metallo-hydrolase	Regulator
H1W74_RS05310 (STHERMO_1211)	vicK	1017448..1018788 (-)	1341	WP_004197359.1	cell wall metabolism sensor histidine kinase VicK	Regulator
H1W74_RS05315 (STHERMO_1212)	vicR	1018781..1019488 (-)	708	WP_011226084.1	response regulator YycF	Regulator
H1W74_RS05320 (STHERMO_1214)	-	1020015..1020782 (+)	768	WP_022096757.1	amino acid ABC transporter ATP-binding protein	-
H1W74_RS05325 (STHERMO_1215)	-	1020794..1021627 (+)	834	WP_022096756.1	transporter substrate-binding domain-containing protein	-
H1W74_RS05330 (STHERMO_1216)	-	1021645..1022343 (+)	699	WP_022096755.1	amino acid ABC transporter permease	-
H1W74_RS05335 (STHERMO_1217)	-	1022355..1023005 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
H1W74_RS05340 (STHERMO_1218)	endA	1023077..1023958 (-)	882	WP_022096754.1	DNA/RNA non-specific endonuclease	Machinery gene
H1W74_RS05345 (STHERMO_1219)	-	1024020..1024208 (-)	189	WP_011226090.1	DNA-directed RNA polymerase subunit beta	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27073.01 Da
• Isoelectric Point: 5.0130

>NTDB_id=1131526 H1W74_RS05315 WP_011226084.1 1018781..1019488(-) (vicR) [Streptococcus thermophilus isolate STH_CIRM_1047]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAKKPDLVILDLMLPELDGLEVAKEIRKTSHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

• Length: 708 bp

>NTDB_id=1131526 H1W74_RS05315 WP_011226084.1 1018781..1019488(-) (vicR) [Streptococcus thermophilus isolate STH_CIRM_1047]
ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGGCGAGAAGCTTTGGAACAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA
TGTTGCCTGAACTGGATGGTTTGGAAGTTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT
AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA
ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACTGCAGTAGAAGAGAGCTCTAACTCTGGCA
AACAAGAAATTTCAATTGGTGAGTTGATTATTGTTCCGGATGCCTTTGTTGCTAAAAAACGTGGAAACGAAGTTGAGTTG
ACCCACCGTGAATTTGAGTTACTCTTCCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC
CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA
CACCTAGCCGTCCTGAATATATCTTGACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-113)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

3D structure

• AlphaFold DB: A0A060BQ44

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	85.532	100	0.855
micA	Streptococcus pneumoniae Cp1015	80.258	99.149	0.796
covR	Streptococcus salivarius strain HSISS4	45.299	99.574	0.451
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.887	98.298	0.451
scnR	Streptococcus mutans UA159	38.559	100	0.387