Detailed information NTG1131508

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: H1W74_RS01395
• Genome accession: NZ_LR822031
• Coordinates: 259059..259958 (+)
• Length: 299 a.a.
• NCBI ID: WP_002946143.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus isolate STH_CIRM_1047
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 254059..264958

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W74_RS01375 (STHERMO_0289)	trkA	255196..256545 (-)	1350	WP_011225444.1	Trk system potassium transporter TrkA	-
H1W74_RS01380 (STHERMO_0291)	-	256804..257343 (+)	540	WP_371851917.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
H1W74_RS01385 (STHERMO_0292)	-	257654..258211 (+)	558	WP_002946140.1	ECF transporter S component	-
H1W74_RS01390 (STHERMO_0293)	-	258214..258864 (+)	651	WP_022096567.1	phosphatase PAP2 family protein	-
H1W74_RS01395 (STHERMO_0295)	comR	259059..259958 (+)	900	WP_002946143.1	helix-turn-helix domain-containing protein	Regulator
H1W74_RS09525	-	260196..261374 (+)	1179	Protein_237	ABC transporter transmembrane domain-containing protein	-
H1W74_RS09530 (STHERMO_0299)	comA	261396..261605 (+)	210	WP_002946147.1	hypothetical protein	Regulator
H1W74_RS01420 (STHERMO_0301)	-	261660..262228 (+)	569	Protein_239	ATP-binding cassette domain-containing protein	-
H1W74_RS01425 (STHERMO_0302)	-	262336..262647 (+)	312	WP_022096570.1	DUF805 domain-containing protein	-
H1W74_RS09540	-	262868..263215 (-)	348	WP_232089310.1	DUF4173 domain-containing protein	-
H1W74_RS09545 (STHERMO_0305)	-	263140..264036 (-)	897	WP_224103642.1	urease cluster protein	-
H1W74_RS01435 (STHERMO_0306)	-	264441..264956 (+)	516	WP_002949547.1	AmiS/UreI family transporter	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35303.77 Da
• Isoelectric Point: 5.1073

>NTDB_id=1131508 H1W74_RS01395 WP_002946143.1 259059..259958(+) (comR) [Streptococcus thermophilus isolate STH_CIRM_1047]
MNLKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=1131508 H1W74_RS01395 WP_002946143.1 259059..259958(+) (comR) [Streptococcus thermophilus isolate STH_CIRM_1047]
TTGAACTTAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (11-66)

• ComR tetratricopeptide (ComR_TPR) (75-292)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	99.666	100	0.997
comR	Streptococcus thermophilus LMD-9	99.666	100	0.997
comR	Streptococcus salivarius strain HSISS4	94.983	100	0.95
comR	Streptococcus salivarius SK126	94.314	100	0.943
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	41.806	100	0.418