Detailed information NTG1131341

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: H1X63_RS04275
• Genome accession: NZ_LR822027
• Coordinates: 816271..816945 (+)
• Length: 224 a.a.
• NCBI ID: WP_179974450.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus isolate STH_CIRM_998
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 811271..821945

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1X63_RS04255 (STHERMO_0885)	-	812383..812970 (-)	588	WP_180487811.1	ECF transporter S component	-
H1X63_RS04260 (STHERMO_0886)	coaC	812998..813543 (-)	546	WP_179972889.1	phosphopantothenoylcysteine decarboxylase	-
H1X63_RS04265 (STHERMO_0887)	-	813536..814219 (-)	684	WP_179974449.1	phosphopantothenate--cysteine ligase	-
H1X63_RS04270 (STHERMO_0888)	-	814413..816083 (+)	1671	WP_180487803.1	formate--tetrahydrofolate ligase	-
H1X63_RS04275 (STHERMO_0889)	ciaR	816271..816945 (+)	675	WP_179974450.1	response regulator transcription factor	Regulator
H1X63_RS04280 (STHERMO_0890)	ciaH	816935..818353 (+)	1419	WP_179974451.1	sensor histidine kinase	Regulator
H1X63_RS04285 (STHERMO_0891)	rpsT	818441..818677 (-)	237	WP_179972893.1	30S ribosomal protein S20	-
H1X63_RS04290 (STHERMO_0892)	coaA	818746..819666 (-)	921	WP_179972894.1	type I pantothenate kinase	-
H1X63_RS04295 (STHERMO_0893)	-	819974..820564 (+)	591	WP_179972895.1	class I SAM-dependent methyltransferase	-
H1X63_RS04305	-	820561..821804 (+)	1244	Protein_800	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25356.02 Da
• Isoelectric Point: 4.2696

>NTDB_id=1131341 H1X63_RS04275 WP_179974450.1 816271..816945(+) (ciaR) [Streptococcus thermophilus isolate STH_CIRM_998]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLKELREQGITTPVIIMTA
KESLDDKGHGFKLGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTISFGDVCVNLSTNSTYVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=1131341 H1X63_RS04275 WP_179974450.1 816271..816945(+) (ciaR) [Streptococcus thermophilus isolate STH_CIRM_998]
ATGATTAAAATTTTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCAGATGT
GATGCAAGTATTTGATGGAGATGAAGGCCTTTACGAAGCTGAAAGTGGTGTTTATGATTTGATTCTTTTGGACTTAATGT
TACCTGAAAAAGATGGTTTTACAGTTCTTAAAGAATTGCGTGAACAAGGAATAACGACTCCTGTTATTATCATGACTGCT
AAGGAAAGTCTAGACGATAAGGGGCATGGCTTTAAACTCGGAGCTGATGATTATCTAACCAAGCCTTTCTATTTAGAAGA
ATTGAAGATGCGTATTCAGGCACTTTTGAAACGTTCTGGAAAATTTGATCAAAATACTATTTCTTTTGGAGATGTTTGTG
TCAACCTTTCTACAAATTCAACCTATGTGGGTGATAAAGAAGTAGAACTTCTCGGTAAAGAATTTGATTTATTGGTCTAC
TTCCTACAAAATCAAAACGTTATTTTGCCCAAGTCGCAAATCTTTGATCGTCTTTGGGGATTTGATAGTGATACTACTGT
CTCTGTTGTTGAAGTTTATGTTTCGAAAATTCGTAAGAAACTTAAGGGGACTGATTTTGCTACCAACCTACAAACCTTAA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae D39	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae R6	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae TIGR4	86.996	99.554	0.866
ciaR	Streptococcus mutans UA159	85.268	100	0.853
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.778	100	0.379
vicR	Streptococcus mutans UA159	35.169	100	0.371
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362