Detailed information NTG1131149

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: H0513_RS04420
• Genome accession: NZ_LR822023
• Coordinates: 829916..830590 (+)
• Length: 224 a.a.
• NCBI ID: WP_179972891.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus isolate STH_CIRM_368
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 824916..835590

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0513_RS04400 (STHERMO_0946)	-	826042..826614 (-)	573	WP_179972994.1	ECF transporter S component	-
H0513_RS04405 (STHERMO_0947)	coaC	826642..827187 (-)	546	WP_179972889.1	phosphopantothenoylcysteine decarboxylase	-
H0513_RS04410 (STHERMO_0948)	-	827180..827863 (-)	684	WP_002948206.1	phosphopantothenate--cysteine ligase	-
H0513_RS04415 (STHERMO_0949)	-	828057..829727 (+)	1671	WP_179972890.1	formate--tetrahydrofolate ligase	-
H0513_RS04420 (STHERMO_0950)	ciaR	829916..830590 (+)	675	WP_179972891.1	response regulator transcription factor	Regulator
H0513_RS04425 (STHERMO_0951)	ciaH	830580..831998 (+)	1419	WP_179972892.1	sensor histidine kinase	Regulator
H0513_RS04430 (STHERMO_0952)	rpsT	832086..832322 (-)	237	WP_179972893.1	30S ribosomal protein S20	-
H0513_RS04435 (STHERMO_0953)	coaA	832391..833311 (-)	921	WP_179972894.1	type I pantothenate kinase	-
H0513_RS04440 (STHERMO_0954)	-	833619..834209 (+)	591	WP_179972895.1	class I SAM-dependent methyltransferase	-
H0513_RS04450	-	834206..835449 (+)	1244	Protein_822	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25329.00 Da
• Isoelectric Point: 4.2696

>NTDB_id=1131149 H0513_RS04420 WP_179972891.1 829916..830590(+) (ciaR) [Streptococcus thermophilus isolate STH_CIRM_368]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLKELREQGITTPVIIMTA
KESLDDKGHGFKLGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTISFGDVCVSLSTNSTYVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=1131149 H0513_RS04420 WP_179972891.1 829916..830590(+) (ciaR) [Streptococcus thermophilus isolate STH_CIRM_368]
ATGATTAAAATTTTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCAGATGT
GATGCAAGTATTTGATGGAGATGAAGGCCTTTACGAAGCTGAAAGTGGTGTTTATGATTTGATTCTTTTGGACTTAATGT
TACCTGAAAAAGATGGTTTTACAGTTCTTAAAGAATTGCGTGAACAAGGAATAACGACTCCTGTTATTATCATGACTGCT
AAGGAAAGTCTAGACGATAAGGGGCATGGCTTTAAACTCGGAGCTGATGATTATCTAACCAAGCCTTTCTATTTAGAAGA
ATTGAAGATGCGTATTCAGGCACTTTTGAAACGTTCTGGAAAATTTGATCAAAATACTATTTCTTTTGGAGATGTTTGTG
TCAGCCTTTCTACAAATTCAACCTATGTGGGTGATAAAGAAGTAGAACTTCTCGGTAAAGAATTTGATTTATTGGTCTAC
TTCCTACAAAATCAAAACGTTATTTTGCCCAAGTCGCAAATCTTTGATCGTCTTTGGGGATTTGATAGTGATACTACTGT
CTCTGTTGTTGAAGTTTATGTTTCGAAAATTCGTAAGAAACTTAAGGGGACTGATTTTGCTACCAACCTACAAACCTTAA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	86.547	99.554	0.862
ciaR	Streptococcus pneumoniae D39	86.547	99.554	0.862
ciaR	Streptococcus pneumoniae R6	86.547	99.554	0.862
ciaR	Streptococcus pneumoniae TIGR4	86.547	99.554	0.862
ciaR	Streptococcus mutans UA159	85.268	100	0.853
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.778	100	0.379
vicR	Streptococcus mutans UA159	35.593	100	0.375
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362