Detailed information NTG1129395

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: GPW48_RS05985
• Genome accession: NZ_LR738720
• Coordinates: 1163474..1164145 (-)
• Length: 223 a.a.
• NCBI ID: WP_009909965.1
• Uniprot ID: A0A075SH40
• Organism: Streptococcus suis isolate GD-0001
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1158474..1169145

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GPW48_RS05965	coaA	1159060..1159980 (+)	921	WP_074390257.1	type I pantothenate kinase	-
GPW48_RS05970	rpsT	1160039..1160287 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
GPW48_RS05975	-	1160549..1161778 (-)	1230	WP_024417479.1	transglutaminase domain-containing protein	-
GPW48_RS05980	ciaH	1162102..1163481 (-)	1380	WP_002935290.1	sensor histidine kinase	Regulator
GPW48_RS05985	ciaR	1163474..1164145 (-)	672	WP_009909965.1	response regulator transcription factor	Regulator
GPW48_RS10785	-	1164339..1164527 (-)	189	WP_226313374.1	hypothetical protein	-
GPW48_RS10870	-	1164585..1164719 (-)	135	WP_255304292.1	hypothetical protein	-
GPW48_RS05995	phoU	1164885..1165541 (-)	657	WP_012028219.1	phosphate signaling complex protein PhoU	-
GPW48_RS06000	pstB	1165570..1166328 (-)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
GPW48_RS06005	pstB	1166340..1167143 (-)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
GPW48_RS06010	pstA	1167168..1168055 (-)	888	WP_002937616.1	phosphate ABC transporter permease PstA	-
GPW48_RS06015	pstC	1168045..1168962 (-)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25290.00 Da
• Isoelectric Point: 4.2183

>NTDB_id=1129395 GPW48_RS05985 WP_009909965.1 1163474..1164145(-) (ciaR) [Streptococcus suis isolate GD-0001]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=1129395 GPW48_RS05985 WP_009909965.1 1163474..1164145(-) (ciaR) [Streptococcus suis isolate GD-0001]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGCCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAATTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A075SH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363