Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   GPW48_RS05980 Genome accession   NZ_LR738720
Coordinates   1162102..1163481 (-) Length   459 a.a.
NCBI ID   WP_002935290.1    Uniprot ID   A0A0Z8I1B6
Organism   Streptococcus suis isolate GD-0001     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1157102..1168481
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GPW48_RS05960 - 1158361..1158951 (-) 591 WP_024417478.1 class I SAM-dependent methyltransferase -
  GPW48_RS05965 coaA 1159060..1159980 (+) 921 WP_074390257.1 type I pantothenate kinase -
  GPW48_RS05970 rpsT 1160039..1160287 (+) 249 WP_012027069.1 30S ribosomal protein S20 -
  GPW48_RS05975 - 1160549..1161778 (-) 1230 WP_024417479.1 transglutaminase domain-containing protein -
  GPW48_RS05980 ciaH 1162102..1163481 (-) 1380 WP_002935290.1 sensor histidine kinase Regulator
  GPW48_RS05985 ciaR 1163474..1164145 (-) 672 WP_009909965.1 response regulator transcription factor Regulator
  GPW48_RS10785 - 1164339..1164527 (-) 189 WP_226313374.1 hypothetical protein -
  GPW48_RS10870 - 1164585..1164719 (-) 135 WP_255304292.1 hypothetical protein -
  GPW48_RS05995 phoU 1164885..1165541 (-) 657 WP_012028219.1 phosphate signaling complex protein PhoU -
  GPW48_RS06000 pstB 1165570..1166328 (-) 759 WP_002937614.1 phosphate ABC transporter ATP-binding protein PstB -
  GPW48_RS06005 pstB 1166340..1167143 (-) 804 WP_002940866.1 phosphate ABC transporter ATP-binding protein PstB -
  GPW48_RS06010 pstA 1167168..1168055 (-) 888 WP_002937616.1 phosphate ABC transporter permease PstA -

Sequence

Protein


Download         Length: 459 a.a.        Molecular weight: 51921.60 Da        Isoelectric Point: 6.8879

>NTDB_id=1129394 GPW48_RS05980 WP_002935290.1 1162102..1163481(-) (ciaH) [Streptococcus suis isolate GD-0001]
MPKRFKKLMYTDKFSFFIRYFAVFTLIFGLMTAIIFQLMRSTMYQNSDNTLKRIKKEPALAVGFAIARTYEPNSVFILQD
SPTGEETTSSSSDSTPVPKNQKNTRAGDQLRLGANTHVLLYSKSGEMINPDTFTGLADLSLDKEKLGEIKETTVESSFGM
SEDYRYITIGLATDELGYYSSYDIKYATILVNVSQIKSSIESYESTVAIVMVSAWLISILASIYLSNLSMRPILISYQKQ
KDFVENASHELRTPLAVLQNRLESLFRHPETTILESSESIGSSLEEVRNMRLLTTNLLNLARRDDGLKVDMIDVQPNYFD
EIFANYLMIAEENGKTLTVNNLIHQPIRTDKVLIKQLLTILFDNAMKYTDDDGTIQMAANIKDKLVCFTVIDNGLGISDA
DKKKIFDRFYRVDKARTRQKGGFGLGLSLAQQIIKNLDGEISVRDNQPKGTIFEVRLPK

Nucleotide


Download         Length: 1380 bp        

>NTDB_id=1129394 GPW48_RS05980 WP_002935290.1 1162102..1163481(-) (ciaH) [Streptococcus suis isolate GD-0001]
ATGCCTAAGCGATTTAAAAAATTAATGTACACAGATAAATTTTCTTTCTTTATCCGTTATTTTGCAGTATTTACTCTGAT
TTTTGGTTTAATGACAGCCATCATTTTTCAATTAATGCGTTCAACTATGTACCAAAATTCAGATAACACCTTGAAACGCA
TTAAGAAAGAACCAGCGCTGGCTGTTGGTTTTGCAATCGCAAGAACCTATGAGCCCAATTCTGTATTTATCCTTCAAGAT
AGTCCAACTGGTGAAGAAACTACGAGCTCTAGTTCAGATAGCACGCCTGTTCCTAAAAATCAAAAAAATACTAGAGCTGG
AGATCAGCTGAGGTTAGGTGCCAATACTCATGTTTTACTCTATAGTAAAAGTGGAGAGATGATTAATCCAGATACTTTTA
CTGGTTTGGCCGACCTATCATTAGACAAGGAAAAATTGGGTGAAATTAAGGAAACTACGGTTGAATCAAGTTTTGGTATG
TCTGAAGATTATCGCTATATAACGATTGGGCTGGCTACAGATGAACTAGGGTATTATTCGTCCTATGATATAAAATATGC
GACAATTTTGGTGAATGTCAGCCAAATTAAATCTTCCATTGAGAGCTATGAATCGACAGTTGCTATTGTTATGGTATCAG
CTTGGTTGATTTCTATACTAGCAAGTATTTACCTATCGAATCTTAGCATGCGTCCAATCCTAATTAGTTATCAAAAACAA
AAAGACTTCGTTGAAAATGCTAGTCATGAGTTACGCACACCGTTGGCAGTTCTTCAAAATCGCCTGGAAAGTCTATTTCG
TCATCCAGAGACAACTATTTTGGAAAGTAGTGAAAGCATCGGATCTAGTTTAGAAGAAGTTCGAAATATGCGACTATTGA
CAACAAATTTACTTAATTTGGCTCGTCGTGATGATGGCTTAAAAGTCGATATGATCGATGTCCAACCCAACTATTTTGAT
GAAATCTTTGCTAATTACCTTATGATTGCCGAAGAAAATGGAAAAACTCTAACAGTTAATAATTTGATTCATCAGCCAAT
TCGAACAGACAAAGTTTTGATTAAACAGTTGCTCACCATTTTGTTTGACAACGCTATGAAGTATACCGATGATGATGGGA
CAATTCAAATGGCAGCTAATATCAAGGATAAACTAGTTTGTTTTACAGTTATTGACAATGGTTTGGGAATCAGCGATGCC
GATAAAAAGAAAATCTTTGATCGCTTTTACCGAGTTGACAAGGCTAGAACACGTCAAAAAGGTGGATTTGGTTTAGGTTT
ATCTTTAGCTCAACAAATTATTAAGAATTTAGATGGTGAGATTTCTGTGAGAGATAACCAACCGAAAGGAACTATTTTTG
AGGTACGTTTACCCAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(240-306)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(350-458)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0Z8I1B6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

49.127

99.782

0.49
  ciaH Streptococcus pneumoniae D39

49.127

99.782

0.49
  ciaH Streptococcus pneumoniae R6

49.127

99.782

0.49
  ciaH Streptococcus pneumoniae TIGR4

49.127

99.782

0.49
  ciaH Streptococcus mutans UA159

48.791

99.129

0.484

Multiple sequence alignment