Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   FGK97_RS04910 Genome accession   NZ_LR594037
Coordinates   985871..986545 (-) Length   224 a.a.
NCBI ID   WP_003024352.1    Uniprot ID   A0AAI9NIE3
Organism   Streptococcus anginosus strain NCTC11064     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 980871..991545
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGK97_RS04900 (NCTC11064_00997) - 982610..984058 (+) 1449 WP_021001736.1 alpha-amylase -
  FGK97_RS09970 - 984255..984389 (-) 135 WP_256381214.1 hypothetical protein -
  FGK97_RS04905 (NCTC11064_00998) ciaH 984535..985881 (-) 1347 WP_106079251.1 sensor histidine kinase Regulator
  FGK97_RS04910 (NCTC11064_00999) ciaR 985871..986545 (-) 675 WP_003024352.1 response regulator transcription factor Regulator
  FGK97_RS04915 (NCTC11064_01000) - 986818..987270 (-) 453 WP_021001738.1 hypothetical protein -
  FGK97_RS04920 (NCTC11064_01001) - 987595..988338 (-) 744 WP_003024349.1 alpha/beta fold hydrolase -
  FGK97_RS04930 (NCTC11064_01003) rplS 988580..988927 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  FGK97_RS04935 (NCTC11064_01004) - 989079..990038 (-) 960 WP_021001748.1 ROK family glucokinase -
  FGK97_RS09805 (NCTC11064_01005) - 990258..990476 (+) 219 WP_003024320.1 helix-turn-helix domain-containing protein -
  FGK97_RS09810 (NCTC11064_01006) - 990817..991095 (+) 279 WP_232043667.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25359.01 Da        Isoelectric Point: 4.2408

>NTDB_id=1127428 FGK97_RS04910 WP_003024352.1 985871..986545(-) (ciaR) [Streptococcus anginosus strain NCTC11064]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1127428 FGK97_RS04910 WP_003024352.1 985871..986545(-) (ciaR) [Streptococcus anginosus strain NCTC11064]
ATGATTAAGATTCTATTAGTAGAAGATGACCTCGGTTTATCTAATTCAGTATTTGACTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAGGAAGGATTGTACGAGGCTGAGAGTGGCGTGTACGACCTTATCTTGCTTGATTTGATGT
TGCCAGAAAAAGACGGTTTCCAAGTATTGAAAGAATTGCGTGAAAAAGGCGTTACCACACCTGTTTTGATTATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGAGCTGACGATTATTTGACCAAACCATTTTATCTGGAAGA
ATTAAAAATGCGGATTCAAGCTCTCTTGAAGCGTTCTGGCAAGTTCAATGAAAACACCCTTTCTTATGGCGATGTCACTG
TTAATTTATCAACAAACACTACACTTGTAGACGGAAATGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GTAGTGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.964

100

0.92
  ciaR Streptococcus pneumoniae D39

91.964

100

0.92
  ciaR Streptococcus pneumoniae R6

91.964

100

0.92
  ciaR Streptococcus pneumoniae TIGR4

91.964

100

0.92
  ciaR Streptococcus mutans UA159

90.135

99.554

0.897
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.767

100

0.393
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment