Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   FGK97_RS04905 Genome accession   NZ_LR594037
Coordinates   984535..985881 (-) Length   448 a.a.
NCBI ID   WP_106079251.1    Uniprot ID   -
Organism   Streptococcus anginosus strain NCTC11064     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 979535..990881
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGK97_RS04885 (NCTC11064_00994) rpsT 979947..980198 (+) 252 WP_020999623.1 30S ribosomal protein S20 -
  FGK97_RS04890 (NCTC11064_00995) - 980263..980772 (+) 510 WP_138099407.1 DNA topology modulation protein -
  FGK97_RS04895 (NCTC11064_00996) - 980820..982433 (-) 1614 WP_138099408.1 M20/M25/M40 family metallo-hydrolase -
  FGK97_RS04900 (NCTC11064_00997) - 982610..984058 (+) 1449 WP_021001736.1 alpha-amylase -
  FGK97_RS09970 - 984255..984389 (-) 135 WP_256381214.1 hypothetical protein -
  FGK97_RS04905 (NCTC11064_00998) ciaH 984535..985881 (-) 1347 WP_106079251.1 sensor histidine kinase Regulator
  FGK97_RS04910 (NCTC11064_00999) ciaR 985871..986545 (-) 675 WP_003024352.1 response regulator transcription factor Regulator
  FGK97_RS04915 (NCTC11064_01000) - 986818..987270 (-) 453 WP_021001738.1 hypothetical protein -
  FGK97_RS04920 (NCTC11064_01001) - 987595..988338 (-) 744 WP_003024349.1 alpha/beta fold hydrolase -
  FGK97_RS04930 (NCTC11064_01003) rplS 988580..988927 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  FGK97_RS04935 (NCTC11064_01004) - 989079..990038 (-) 960 WP_021001748.1 ROK family glucokinase -
  FGK97_RS09805 (NCTC11064_01005) - 990258..990476 (+) 219 WP_003024320.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50988.75 Da        Isoelectric Point: 10.1380

>NTDB_id=1127427 FGK97_RS04905 WP_106079251.1 984535..985881(-) (ciaH) [Streptococcus anginosus strain NCTC11064]
MLNKLKKTWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARRVGMEQKSDNGE
PKTDTGDKELTDKPNVSANTEVILFDKNYKPIITSNNFLGLNKLSFNSKQLDRIRQVQVKSNYGRQETYRMILFEVKIPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKIFRF
DNRIHRVIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTIAVKDNKPKGTIFEVKIAIRTDNRKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=1127427 FGK97_RS04905 WP_106079251.1 984535..985881(-) (ciaH) [Streptococcus anginosus strain NCTC11064]
ATGCTGAATAAACTTAAAAAAACATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCCATGACTTTGATTATCATTCAGGTGATGCGCTCAAGCCTTTATACAACGGTCGATAATAACTTGAAAAGTC
TCAGTCAGGATTCCGCTTCTGTCATCAATTTGGCGCTCGCTCGGAGAGTGGGGATGGAACAGAAGTCAGACAACGGAGAG
CCTAAAACCGACACGGGTGACAAAGAGCTTACTGATAAACCAAATGTCAGTGCCAATACGGAAGTTATTTTATTTGATAA
GAATTATAAGCCAATCATTACAAGCAATAATTTTCTGGGACTTAATAAACTTTCCTTTAATAGCAAGCAATTGGATCGCA
TTCGGCAAGTCCAGGTTAAAAGCAATTATGGTCGACAAGAAACCTATCGGATGATTTTATTTGAAGTGAAAATCCCAAAT
TTGGAAACCAATGTCAAATATGCAGCGGTCTTTATCAATATCAGTCAGTTGGAACAAACTAGTCAAAATCATGAGCAGCT
GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCCAGTGTCTATCTGGCTCGAGTTAGTGTTAAACCTT
TGTTGGAAAGCATTCAAAAGCAAAAGAGTTTTGTCGAAAATGCCAGTCATGAGTTGCGCACGCCTCTAGCTGTTTTACAA
AATCGTTTGGAGACTTTGTTTAGAAAACCAGAAGCCACCATTATGGAATCAAGCGAAAGCATTGCTTCTAGTTTGGATGA
AGTGCGGAACATGAAAATGTTGACGACAAATCTGCTTAATCTAGCACGGCGTGACGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACGACCTTTACCAACTATGAAATGGTTGCCGCAGAGAATGGGAAAATTTTCCGATTT
GACAATAGGATTCACCGCGTAATTAAAACGGATAAAACCTTACTGAAGCAATTGATGACTATCTTGTTTGATAATGCCCT
GAAATATACAGATGAAGATGGTGTGATTGAATTGACAATTTCTGCAAATGATCGAAATTTGTTTTTGAAGGTTTCGGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCACGGACTCGGCAG
ACAGGTGGTTTTGGTTTAGGGTTGTCGCTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACCATTGCAGTGAAAGACAA
TAAGCCTAAAGGAACTATTTTTGAGGTGAAGATTGCCATTAGAACGGACAATAGAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

71.205

100

0.712
  ciaH Streptococcus pneumoniae D39

71.205

100

0.712
  ciaH Streptococcus pneumoniae R6

71.205

100

0.712
  ciaH Streptococcus pneumoniae TIGR4

71.205

100

0.712
  ciaH Streptococcus mutans UA159

56.009

98.438

0.551

Multiple sequence alignment