Detailed information NTG1127316

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: FGL04_RS08580
• Genome accession: NZ_LR594035
• Coordinates: 1663328..1663918 (-)
• Length: 196 a.a.
• NCBI ID: WP_003083781.1
• Uniprot ID: A0A4V0H7V7
• Organism: Streptococcus pseudoporcinus strain NCTC5385
• Function: degradation of ComX; require for competence development (at the early growth phase); repress competence development (at the mid-logarithmic growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 1658328..1668918

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL04_RS08550 (NCTC5385_01860)	-	1658384..1659147 (-)	764	Protein_1683	ABC transporter ATP-binding protein	-
FGL04_RS08555 (NCTC5385_01861)	-	1659148..1660101 (-)	954	WP_138068887.1	branched-chain amino acid ABC transporter permease	-
FGL04_RS08560 (NCTC5385_01862)	-	1660104..1660973 (-)	870	WP_138068888.1	branched-chain amino acid ABC transporter permease	-
FGL04_RS08565 (NCTC5385_01863)	-	1661017..1662189 (-)	1173	WP_138068890.1	ABC transporter substrate-binding protein	-
FGL04_RS08570 (NCTC5385_01864)	-	1662344..1662592 (-)	249	WP_007895846.1	DUF2129 domain-containing protein	-
FGL04_RS08575 (NCTC5385_01865)	-	1662562..1663038 (-)	477	WP_138068891.1	YlbF family regulator	-
FGL04_RS08580 (NCTC5385_01866)	clpP	1663328..1663918 (-)	591	WP_003083781.1	ATP-dependent Clp protease proteolytic subunit ClpP	Regulator
FGL04_RS08585 (NCTC5385_01867)	upp	1664129..1664758 (-)	630	WP_007895697.1	uracil phosphoribosyltransferase	-
FGL04_RS08590 (NCTC5385_01868)	-	1664988..1666622 (-)	1635	WP_138068892.1	putative polysaccharide biosynthesis protein	-
FGL04_RS08595 (NCTC5385_01869)	-	1666709..1668166 (+)	1458	WP_138068893.1	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	-

Sequence

Protein

• Length: 196 a.a.
• Molecular weight: 21743.01 Da
• Isoelectric Point: 4.8856

>NTDB_id=1127316 FGL04_RS08580 WP_003083781.1 1663328..1663918(-) (clpP) [Streptococcus pseudoporcinus strain NCTC5385]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKSDVQTIVMGMAASMGTIIASSGAKGKRFMLPNAEYLIHQPMGGAGSGTQQTDMAIVAEQLLKTRKRLEKILADNSGK
TIKQIHKDAERDYWMDAKETLEYGFIDEIMENNELK

Nucleotide

• Length: 591 bp

>NTDB_id=1127316 FGL04_RS08580 WP_003083781.1 1663328..1663918(-) (clpP) [Streptococcus pseudoporcinus strain NCTC5385]
ATGATTCCTGTAGTTATTGAACAAACAAGTCGCGGAGAACGTTCTTATGATATCTATTCACGTCTCCTAAAAGATCGTAT
TATTATGCTAACTGGACCAGTTGAAGATAATATGGCAAATTCTATTATTGCACAGTTACTATTTTTGGACGCGCAAGATA
ATACTAAAGATATTTACCTCTATGTAAATACACCCGGAGGATCGGTTTCAGCTGGGTTAGCAATTGTTGATACGATGAAC
TTTATTAAATCAGATGTTCAAACGATTGTTATGGGGATGGCTGCCTCAATGGGAACGATCATTGCATCATCAGGTGCCAA
AGGCAAACGATTCATGCTACCAAATGCTGAATACTTAATTCATCAACCGATGGGGGGCGCTGGTAGTGGTACGCAACAAA
CAGATATGGCAATTGTTGCTGAACAATTGTTAAAAACACGGAAACGCCTTGAAAAAATTCTTGCTGATAATTCTGGTAAG
ACTATTAAACAAATTCACAAAGATGCAGAACGTGACTACTGGATGGATGCCAAAGAAACATTGGAATATGGCTTCATTGA
TGAAATCATGGAAAATAATGAATTAAAATAA

Domains

Predicted by InterproScan.

• Clp protease (CLP_protease) (11-192)

3D structure

• AlphaFold DB: A0A4V0H7V7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Streptococcus mutans UA159	94.898	100	0.949
clpP	Streptococcus pyogenes JRS4	92.347	100	0.923
clpP	Streptococcus pyogenes MGAS315	92.347	100	0.923
clpP	Lactococcus lactis subsp. cremoris KW2	91.837	100	0.918
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	91.327	100	0.913
clpP	Streptococcus thermophilus LMD-9	89.286	100	0.893
clpP	Streptococcus thermophilus LMG 18311	89.286	100	0.893
clpP	Streptococcus pneumoniae Rx1	87.692	99.49	0.872
clpP	Streptococcus pneumoniae D39	87.692	99.49	0.872
clpP	Streptococcus pneumoniae R6	87.692	99.49	0.872
clpP	Streptococcus pneumoniae TIGR4	87.692	99.49	0.872
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	57.513	98.469	0.566
clpP	Bacillus subtilis subsp. subtilis str. 168	56.122	100	0.561