Detailed information    

insolico Bioinformatically predicted

Overview


Name   comB   Type   Regulator
Locus tag   FGL04_RS08155 Genome accession   NZ_LR594035
Coordinates   1586356..1586616 (-) Length   86 a.a.
NCBI ID   WP_138068839.1    Uniprot ID   A0A4U9Z733
Organism   Streptococcus pseudoporcinus strain NCTC5385     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1571995..1589655 1586356..1586616 within 0
IScluster/Tn 1587207..1588312 1586356..1586616 flank 591


Gene organization within MGE regions


Location: 1571995..1589655
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL04_RS08075 (NCTC5385_01759) - 1571995..1573100 (+) 1106 WP_138068165.1 IS3 family transposase -
  FGL04_RS08080 - 1573145..1573552 (-) 408 Protein_1588 transposase -
  FGL04_RS08090 (NCTC5385_01761) - 1573570..1573815 (+) 246 WP_225247815.1 hypothetical protein -
  FGL04_RS08095 (NCTC5385_01762) - 1573975..1574514 (+) 540 WP_138068830.1 SdpI family protein -
  FGL04_RS08100 (NCTC5385_01763) - 1575112..1575375 (+) 264 WP_138068831.1 hypothetical protein -
  FGL04_RS08105 (NCTC5385_01765) - 1575428..1576533 (+) 1106 WP_138068832.1 IS3 family transposase -
  FGL04_RS08110 (NCTC5385_01766) - 1576542..1576724 (-) 183 WP_138068833.1 hypothetical protein -
  FGL04_RS08115 (NCTC5385_01767) - 1576939..1578603 (-) 1665 WP_138068834.1 ABC transporter permease -
  FGL04_RS08120 (NCTC5385_01768) - 1578604..1579683 (-) 1080 WP_138068835.1 ABC transporter ATP-binding protein -
  FGL04_RS08125 (NCTC5385_01769) - 1579693..1580727 (-) 1035 WP_138068836.1 ABC transporter substrate-binding protein -
  FGL04_RS08130 (NCTC5385_01770) - 1580803..1581399 (-) 597 WP_225247816.1 helix-turn-helix domain-containing protein -
  FGL04_RS11100 (NCTC5385_01771) - 1581399..1581557 (-) 159 WP_225247817.1 hypothetical protein -
  FGL04_RS08135 (NCTC5385_01772) - 1581545..1582852 (-) 1308 WP_225247818.1 sensor histidine kinase -
  FGL04_RS11105 (NCTC5385_01773) - 1582948..1583238 (-) 291 WP_225247819.1 hypothetical protein -
  FGL04_RS08140 (NCTC5385_01774) - 1584110..1584292 (-) 183 WP_138069170.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  FGL04_RS08145 (NCTC5385_01775) - 1584311..1584562 (-) 252 WP_138068837.1 Blp family class II bacteriocin -
  FGL04_RS08150 (NCTC5385_01776) - 1585514..1586035 (-) 522 WP_138068838.1 HlyD family efflux transporter periplasmic adaptor subunit -
  FGL04_RS08155 (NCTC5385_01778) comB 1586356..1586616 (-) 261 WP_138068839.1 hypothetical protein Regulator
  FGL04_RS08160 (NCTC5385_01779) - 1586626..1587123 (-) 498 Protein_1605 ATP-binding cassette domain-containing protein -
  FGL04_RS08165 (NCTC5385_01781) - 1587207..1588312 (+) 1106 WP_138068165.1 IS3 family transposase -

Sequence


Protein


Download         Length: 86 a.a.        Molecular weight: 10168.03 Da        Isoelectric Point: 9.8257

>NTDB_id=1127313 FGL04_RS08155 WP_138068839.1 1586356..1586616(-) (comB) [Streptococcus pseudoporcinus strain NCTC5385]
MNEDLLESSEYYQKRYHNFSTLIIIPIFSLLIFLGFFFIFMKKEITIKSVGTIKPVKIIEKIQSTSDNLVIKNNLEENRS
VKKMTF

Nucleotide


Download         Length: 261 bp        

>NTDB_id=1127313 FGL04_RS08155 WP_138068839.1 1586356..1586616(-) (comB) [Streptococcus pseudoporcinus strain NCTC5385]
ATGAATGAAGACTTATTAGAAAGTTCCGAATATTATCAAAAAAGATATCATAATTTTTCGACATTGATTATTATACCTAT
TTTTTCACTATTAATCTTTTTAGGATTTTTCTTTATATTTATGAAAAAAGAAATCACTATCAAGTCTGTGGGAACTATTA
AGCCTGTAAAAATTATAGAAAAAATCCAATCAACAAGTGATAATCTCGTCATTAAAAATAATCTAGAAGAAAATAGGAGT
GTGAAAAAAATGACGTTCTAA

Domains



No domain identified.



Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A4U9Z733

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus mutans UA159

51.807

96.512

0.5

  comB Streptococcus gordonii str. Challis substr. CH1

50.602

96.512

0.488

  comB/nlmE Streptococcus mutans UA159

50.602

96.512

0.488

  comB Streptococcus pneumoniae D39

45.783

96.512

0.442

  comB Streptococcus pneumoniae R6

45.783

96.512

0.442

  comB Streptococcus mitis SK321

45.783

96.512

0.442

  comB Streptococcus mitis NCTC 12261

45.783

96.512

0.442

  comB Streptococcus pneumoniae TIGR4

45.783

96.512

0.442

  comB Streptococcus pneumoniae Rx1

45.783

96.512

0.442


Multiple sequence alignment