Detailed information NTG0000404

Experimentally validated

Overview

• Name: comB
• Type: Regulator
• Locus tag: SMU_RS08660
• Genome accession: NC_004350
• Coordinates: 1786502..1787515 (+)
• Length: 337 a.a.
• NCBI ID: WP_002263739.1
• Uniprot ID: Q8DSA7
• Organism: Streptococcus mutans UA159
• Function: transport of ComC Competence regulation

Function

Gene inactivation resulted in a mutant deficient in transformability.

Genomic Context

Location: 1781502..1792515

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMU_RS08635 (SMU.1892c)	-	1781694..1781879 (-)	186	WP_002263346.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SMU_RS08645 (SMU.1895c)	-	1783456..1783617 (-)	162	WP_002263734.1	Blp family class II bacteriocin	-
SMU_RS08650 (SMU.1896c)	-	1783662..1783916 (-)	255	WP_002263733.1	Blp family class II bacteriocin	-
SMU_RS08655 (SMU.1898)	comA	1784304..1786489 (+)	2186	Protein_1681	peptide cleavage/export ABC transporter	Regulator
SMU_RS08660 (SMU.1900)	comB	1786502..1787515 (+)	1014	WP_002263739.1	HlyD family efflux transporter periplasmic adaptor subunit	Regulator
SMU_RS09965 (SMU.1902c)	-	1787777..1787920 (-)	144	WP_002263740.1	hypothetical protein	-
SMU_RS08665 (SMU.1904c)	-	1788212..1789234 (-)	1023	WP_002263742.1	thioredoxin family protein	-
SMU_RS08670 (SMU.1905c)	-	1789720..1789908 (-)	189	WP_002263743.1	Blp family class II bacteriocin	-
SMU_RS08675 (SMU.1906c)	-	1790072..1790284 (-)	213	WP_002263744.1	Blp family class II bacteriocin	-
SMU_RS09970 (SMU.1908c)	-	1790689..1790853 (-)	165	WP_002265308.1	hypothetical protein	-
SMU_RS10085	-	1791293..1791505 (+)	213	Protein_1688	IS3 family transposase	-
SMU_RS08680 (SMU.1909c)	-	1791628..1792032 (-)	405	WP_002263912.1	hypothetical protein	-

Sequence

Protein

• Length: 337 a.a.
• Molecular weight: 38498.13 Da
• Isoelectric Point: 10.7202

>NTDB_id=404 SMU_RS08660 WP_002263739.1 1786502..1787515(+) (comB) [Streptococcus mutans UA159]
MNPNLFKSAEFYRRRYHNFATVLIIPLVCLLVFLFIFLLFAKKEVTVLSDGEISPIKVIDVIQSKSDYPISENNLTDNHA
VKKRDVLIQYVNPAANTRQGGNNQNQNQSQNKQNKNQQQNNKNQKNGNQGQKNQNQNQNKKDQKNNNQSQQNKQGQKKTN
QSQNQQNKNQNKNQSQNKQNGNQNQNNWNQNNQNDKVTASQDGVIHTNPKYEGENLIPRGTEIAQLYPDINKTRQVLITY
YVSSKDVTRLKQGQKTHLALTKVGNDQISIRGKINSIASAATTTKKGNVFKVTAKAKVSKKDSQTIKYGLQGKTITVVEK
KTFFDYYKDKLLNKNQK

Nucleotide

• Length: 1014 bp

>NTDB_id=404 SMU_RS08660 WP_002263739.1 1786502..1787515(+) (comB) [Streptococcus mutans UA159]
ATGAACCCAAATTTATTTAAAAGCGCTGAATTCTACCGAAGACGCTATCATAATTTTGCTACAGTTCTTATTATTCCTTT
GGTTTGTTTACTTGTATTTTTATTTATCTTTCTATTATTTGCTAAAAAAGAGGTCACTGTCTTGTCTGATGGCGAGATCT
CTCCCATTAAAGTAATTGATGTTATTCAATCTAAAAGTGATTATCCCATTTCTGAAAATAATTTAACAGATAATCACGCC
GTTAAAAAAAGGGATGTTCTCATCCAATATGTTAATCCAGCAGCAAATACAAGACAGGGCGGAAATAATCAGAATCAAAA
TCAATCTCAAAACAAGCAAAATAAGAATCAGCAGCAAAACAATAAGAATCAAAAAAACGGCAATCAAGGTCAAAAAAATC
AAAATCAGAACCAAAATAAAAAGGATCAGAAAAACAATAACCAATCTCAGCAAAACAAGCAAGGACAAAAGAAAACTAAT
CAATCCCAAAATCAGCAGAATAAGAATCAAAATAAAAACCAATCTCAAAACAAACAAAATGGGAATCAAAACCAAAATAA
CTGGAATCAGAATAATCAAAATGATAAAGTCACAGCCAGCCAAGATGGTGTTATCCATACCAACCCCAAATATGAAGGTG
AAAACTTAATTCCTCGGGGGACTGAAATCGCACAGCTCTATCCAGATATTAACAAAACAAGACAAGTTCTGATCACTTAT
TACGTCTCCTCTAAAGATGTCACCCGCCTCAAACAAGGCCAAAAGACTCATCTTGCTTTAACCAAGGTAGGAAATGATCA
AATTTCCATTAGAGGAAAAATTAATAGTATCGCTTCAGCTGCTACAACGACGAAAAAAGGCAATGTTTTTAAAGTGACAG
CTAAAGCAAAAGTTTCTAAAAAAGACAGCCAAACCATTAAATACGGCCTCCAGGGTAAAACCATCACAGTTGTTGAAAAA
AAGACTTTCTTTGATTATTATAAAGATAAACTGTTAAATAAAAATCAAAAATAA

Domains

Predicted by InterProScan.

• HlyD family secretion protein (HlyD_3) (196-309)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comB/nlmE	Streptococcus mutans UA159	50.299	99.11	0.499