Detailed information
Bioinformatically predicted
Overview
| Name | prx | Type | Regulator |
| Locus tag | FGK99_RS04625 | Genome accession | NZ_LR594033 |
| Coordinates | 975933..976121 (+) | Length | 62 a.a. |
| NCBI ID | WP_138119241.1 | Uniprot ID | - |
| Organism | Streptococcus equi subsp. zooepidemicus strain NCTC4675 | ||
| Function | Inhibit ComR activation (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 939315..983689 | 975933..976121 | within | 0 |
Gene organization within MGE regions
Location: 939315..983689
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FGK99_RS04350 (NCTC4675_00881) | - | 939315..940403 (-) | 1089 | WP_138119153.1 | tyrosine-type recombinase/integrase | - |
| FGK99_RS04355 (NCTC4675_00882) | - | 940527..941384 (-) | 858 | WP_138119155.1 | DNA adenine methylase | - |
| FGK99_RS04360 (NCTC4675_00883) | - | 941442..943094 (-) | 1653 | WP_231149143.1 | AAA family ATPase | - |
| FGK99_RS04365 (NCTC4675_00884) | - | 943104..943487 (-) | 384 | WP_138119157.1 | ImmA/IrrE family metallo-endopeptidase | - |
| FGK99_RS04370 (NCTC4675_00885) | - | 943471..943812 (-) | 342 | WP_138119158.1 | helix-turn-helix domain-containing protein | - |
| FGK99_RS04375 (NCTC4675_00886) | - | 944009..944221 (+) | 213 | WP_138119161.1 | helix-turn-helix transcriptional regulator | - |
| FGK99_RS04380 (NCTC4675_00887) | - | 944338..944628 (+) | 291 | WP_138119163.1 | MerR family transcriptional regulator | - |
| FGK99_RS04385 (NCTC4675_00888) | - | 944630..944815 (+) | 186 | WP_138119165.1 | hypothetical protein | - |
| FGK99_RS04390 | - | 944909..945178 (+) | 270 | WP_331852325.1 | transcriptional regulator | - |
| FGK99_RS04395 (NCTC4675_00889) | - | 945382..945765 (+) | 384 | WP_050316830.1 | DnaD domain-containing protein | - |
| FGK99_RS04400 (NCTC4675_00890) | - | 945746..945979 (+) | 234 | WP_012678838.1 | hypothetical protein | - |
| FGK99_RS04405 (NCTC4675_00891) | - | 945976..946116 (+) | 141 | WP_138119167.1 | hypothetical protein | - |
| FGK99_RS04410 (NCTC4675_00892) | - | 946125..946331 (+) | 207 | WP_138119169.1 | hypothetical protein | - |
| FGK99_RS04415 (NCTC4675_00893) | - | 946493..947410 (+) | 918 | WP_138119171.1 | recombinase RecT | - |
| FGK99_RS04420 (NCTC4675_00894) | - | 947407..947607 (+) | 201 | WP_138119173.1 | hypothetical protein | - |
| FGK99_RS04425 (NCTC4675_00895) | - | 947600..948397 (+) | 798 | WP_138119175.1 | PD-(D/E)XK nuclease-like domain-containing protein | - |
| FGK99_RS04430 (NCTC4675_00896) | - | 948574..948915 (+) | 342 | WP_138119177.1 | hypothetical protein | - |
| FGK99_RS04435 (NCTC4675_00897) | - | 948912..949424 (+) | 513 | WP_138119179.1 | crossover junction endodeoxyribonuclease RuvC | - |
| FGK99_RS04440 (NCTC4675_00898) | - | 949411..949605 (+) | 195 | WP_138119181.1 | hypothetical protein | - |
| FGK99_RS04445 | - | 949649..949813 (+) | 165 | Protein_857 | DUF1642 domain-containing protein | - |
| FGK99_RS04450 (NCTC4675_00899) | - | 949776..950123 (+) | 348 | WP_138119183.1 | hypothetical protein | - |
| FGK99_RS04455 (NCTC4675_00900) | - | 950315..950752 (+) | 438 | WP_138119185.1 | DUF1492 domain-containing protein | - |
| FGK99_RS04460 (NCTC4675_00901) | relB | 950922..951155 (+) | 234 | WP_138119187.1 | type II toxin-antitoxin system RelB family antitoxin | - |
| FGK99_RS04465 (NCTC4675_00902) | - | 951152..951409 (+) | 258 | WP_138119189.1 | type II toxin-antitoxin system RelE family toxin | - |
| FGK99_RS04470 (NCTC4675_00903) | - | 951467..951820 (+) | 354 | WP_231148477.1 | phBC6A51 family helix-turn-helix protein | - |
| FGK99_RS04475 (NCTC4675_00904) | - | 951810..953084 (+) | 1275 | WP_138119193.1 | PBSX family phage terminase large subunit | - |
| FGK99_RS04480 (NCTC4675_00905) | - | 953084..954385 (+) | 1302 | WP_138119195.1 | phage portal protein | - |
| FGK99_RS04485 (NCTC4675_00906) | - | 954378..955286 (+) | 909 | WP_138119197.1 | minor capsid protein | - |
| FGK99_RS04490 (NCTC4675_00908) | - | 955614..956183 (+) | 570 | WP_138119199.1 | DUF4355 domain-containing protein | - |
| FGK99_RS04495 (NCTC4675_00909) | - | 956203..957093 (+) | 891 | WP_138119201.1 | phage capsid protein | - |
| FGK99_RS04500 (NCTC4675_00910) | - | 957107..957400 (+) | 294 | WP_138119202.1 | HeH/LEM domain-containing protein | - |
| FGK99_RS04505 (NCTC4675_00911) | - | 957414..957758 (+) | 345 | WP_138119204.1 | phage head-tail connector protein | - |
| FGK99_RS04510 (NCTC4675_00912) | - | 957755..958066 (+) | 312 | WP_138119206.1 | hypothetical protein | - |
| FGK99_RS04515 (NCTC4675_00913) | - | 958063..958458 (+) | 396 | WP_138119207.1 | hypothetical protein | - |
| FGK99_RS04520 (NCTC4675_00914) | - | 958460..958870 (+) | 411 | WP_138119209.1 | DUF5072 family protein | - |
| FGK99_RS04525 (NCTC4675_00915) | - | 958883..959389 (+) | 507 | WP_138119211.1 | phage major tail protein, TP901-1 family | - |
| FGK99_RS04530 (NCTC4675_00916) | - | 959401..959718 (+) | 318 | WP_138119213.1 | hypothetical protein | - |
| FGK99_RS04535 (NCTC4675_00917) | - | 959691..960149 (+) | 459 | WP_138119215.1 | hypothetical protein | - |
| FGK99_RS04540 (NCTC4675_00918) | - | 960142..961947 (+) | 1806 | WP_138119217.1 | phage tail protein | - |
| FGK99_RS04545 (NCTC4675_00919) | - | 961948..963429 (+) | 1482 | WP_138119219.1 | distal tail protein Dit | - |
| FGK99_RS04550 (NCTC4675_00920) | - | 963430..966861 (+) | 3432 | WP_138119221.1 | phage tail protein | - |
| FGK99_RS04555 (NCTC4675_00921) | - | 966866..968722 (+) | 1857 | WP_138119223.1 | DUF859 family phage minor structural protein | - |
| FGK99_RS04560 (NCTC4675_00922) | - | 968733..969083 (+) | 351 | WP_138119225.1 | DUF1366 domain-containing protein | - |
| FGK99_RS10115 (NCTC4675_00923) | - | 969097..969219 (+) | 123 | WP_269206307.1 | hypothetical protein | - |
| FGK99_RS04565 (NCTC4675_00924) | - | 969232..969531 (+) | 300 | WP_138119227.1 | hypothetical protein | - |
| FGK99_RS04570 (NCTC4675_00925) | - | 969533..969868 (+) | 336 | WP_138119229.1 | phage holin | - |
| FGK99_RS04575 (NCTC4675_00926) | - | 969870..970634 (+) | 765 | WP_138119231.1 | CHAP domain-containing protein | - |
| FGK99_RS04580 (NCTC4675_00927) | - | 970646..971248 (+) | 603 | WP_138119233.1 | hypothetical protein | - |
| FGK99_RS04585 (NCTC4675_00928) | - | 971259..972032 (+) | 774 | WP_138119235.1 | hypothetical protein | - |
| FGK99_RS04590 (NCTC4675_00929) | - | 972042..972473 (+) | 432 | WP_231148479.1 | collagen-like triple helix repeat-containing protein | - |
| FGK99_RS04595 (NCTC4675_00930) | - | 972475..973089 (+) | 615 | WP_138119237.1 | hypothetical protein | - |
| FGK99_RS04600 (NCTC4675_00931) | - | 973289..974494 (+) | 1206 | WP_138119239.1 | Fic family protein | - |
| FGK99_RS04615 (NCTC4675_00932) | - | 975010..975585 (+) | 576 | WP_012679345.1 | phospholipase A2 SlaA | - |
| FGK99_RS04625 (NCTC4675_00934) | prx | 975933..976121 (+) | 189 | WP_138119241.1 | Paratox | Regulator |
| FGK99_RS04635 (NCTC4675_00936) | - | 976713..977324 (+) | 612 | WP_012678047.1 | TVP38/TMEM64 family protein | - |
| FGK99_RS04640 (NCTC4675_00937) | - | 977371..978165 (-) | 795 | WP_012515506.1 | hypothetical protein | - |
| FGK99_RS04645 (NCTC4675_00938) | - | 978175..978873 (-) | 699 | WP_012515507.1 | ABC transporter ATP-binding protein | - |
| FGK99_RS04650 (NCTC4675_00939) | - | 978873..979244 (-) | 372 | WP_012515508.1 | GntR family transcriptional regulator | - |
| FGK99_RS04655 (NCTC4675_00940) | - | 979486..982596 (+) | 3111 | WP_138119243.1 | DNA polymerase III subunit alpha | - |
| FGK99_RS04660 (NCTC4675_00941) | pfkA | 982676..983689 (+) | 1014 | WP_138119245.1 | 6-phosphofructokinase | - |
Sequence
Protein
Download Length: 62 a.a. Molecular weight: 7229.19 Da Isoelectric Point: 4.5164
>NTDB_id=1127177 FGK99_RS04625 WP_138119241.1 975933..976121(+) (prx) [Streptococcus equi subsp. zooepidemicus strain NCTC4675]
MLTYDEFKQAIDDGYIAGDTVAIVRKNGQIFDYVLPHESVRSWEVVTEERVEAVLKELHYIK
MLTYDEFKQAIDDGYIAGDTVAIVRKNGQIFDYVLPHESVRSWEVVTEERVEAVLKELHYIK
Nucleotide
Download Length: 189 bp
>NTDB_id=1127177 FGK99_RS04625 WP_138119241.1 975933..976121(+) (prx) [Streptococcus equi subsp. zooepidemicus strain NCTC4675]
ATGCTAACATACGACGAATTTAAGCAAGCTATTGACGACGGTTATATCGCAGGCGACACAGTAGCGATTGTGCGCAAAAA
CGGACAGATTTTTGATTATGTGTTGCCGCATGAGTCTGTGAGATCGTGGGAGGTTGTGACTGAAGAAAGAGTAGAAGCAG
TACTAAAAGAATTACACTATATTAAATGA
ATGCTAACATACGACGAATTTAAGCAAGCTATTGACGACGGTTATATCGCAGGCGACACAGTAGCGATTGTGCGCAAAAA
CGGACAGATTTTTGATTATGTGTTGCCGCATGAGTCTGTGAGATCGTGGGAGGTTGTGACTGAAGAAAGAGTAGAAGCAG
TACTAAAAGAATTACACTATATTAAATGA
Domains
No domain identified.
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| prx | Streptococcus pyogenes MGAS315 |
82.258 |
100 |
0.823 |
| prx | Streptococcus pyogenes MGAS315 |
82.759 |
93.548 |
0.774 |
| prx | Streptococcus pyogenes MGAS8232 |
82.759 |
93.548 |
0.774 |
| prx | Streptococcus pyogenes MGAS315 |
81.034 |
93.548 |
0.758 |
| prx | Streptococcus pyogenes MGAS315 |
72.881 |
95.161 |
0.694 |
| prx | Streptococcus pyogenes MGAS315 |
88.095 |
67.742 |
0.597 |
| prx | Streptococcus pyogenes MGAS315 |
80.952 |
67.742 |
0.548 |