Detailed information NTG1126574

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: E0F34_RS09295
• Genome accession: NZ_LR536843
• Coordinates: 1718977..1719681 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1713977..1724681

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F34_RS09270 (SAMEA104035599_01765)	-	1714289..1716160 (-)	1872	WP_000150986.1	Eco57I restriction-modification methylase domain-containing protein	-
E0F34_RS09275 (SAMEA104035599_01766)	-	1716235..1716489 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE family toxin	-
E0F34_RS09280 (SAMEA104035599_01767)	relB	1716491..1716733 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
E0F34_RS09285 (SAMEA104035599_01768)	vicX	1716824..1717633 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
E0F34_RS09290 (SAMEA104035599_01769)	micB	1717635..1718984 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
E0F34_RS09295 (SAMEA104035599_01770)	micA	1718977..1719681 (-)	705	WP_000722076.1	response regulator YycF	Regulator
E0F34_RS09300 (SAMEA104035599_01771)	mutY	1719736..1720911 (-)	1176	WP_050202456.1	A/G-specific adenine glycosylase	-
E0F34_RS12185	-	1721008..1721133 (+)	126	WP_001818232.1	hypothetical protein	-
E0F34_RS09305 (SAMEA104035599_01772)	-	1721239..1722909 (-)	1671	WP_000845292.1	formate--tetrahydrofolate ligase	-
E0F34_RS09310 (SAMEA104035599_01773)	coaB	1723139..1723828 (+)	690	WP_000699493.1	phosphopantothenate--cysteine ligase	-
E0F34_RS09315 (SAMEA104035599_01774)	coaC	1723840..1724391 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=1126574 E0F34_RS09295 WP_000722076.1 1718977..1719681(-) (micA) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1126574 E0F34_RS09295 WP_000722076.1 1718977..1719681(-) (micA) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTATGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACACGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38