Detailed information NTG1126573

Bioinformatically predicted

Overview

• Name: micB
• Type: Regulator
• Locus tag: E0F34_RS09290
• Genome accession: NZ_LR536843
• Coordinates: 1717635..1718984 (-)
• Length: 449 a.a.
• NCBI ID: WP_000886210.1
• Uniprot ID: A0A064BZM9
• Organism: Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1712635..1723984

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F34_RS09270 (SAMEA104035599_01765)	-	1714289..1716160 (-)	1872	WP_000150986.1	Eco57I restriction-modification methylase domain-containing protein	-
E0F34_RS09275 (SAMEA104035599_01766)	-	1716235..1716489 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE family toxin	-
E0F34_RS09280 (SAMEA104035599_01767)	relB	1716491..1716733 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
E0F34_RS09285 (SAMEA104035599_01768)	vicX	1716824..1717633 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
E0F34_RS09290 (SAMEA104035599_01769)	micB	1717635..1718984 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
E0F34_RS09295 (SAMEA104035599_01770)	micA	1718977..1719681 (-)	705	WP_000722076.1	response regulator YycF	Regulator
E0F34_RS09300 (SAMEA104035599_01771)	mutY	1719736..1720911 (-)	1176	WP_050202456.1	A/G-specific adenine glycosylase	-
E0F34_RS12185	-	1721008..1721133 (+)	126	WP_001818232.1	hypothetical protein	-
E0F34_RS09305 (SAMEA104035599_01772)	-	1721239..1722909 (-)	1671	WP_000845292.1	formate--tetrahydrofolate ligase	-
E0F34_RS09310 (SAMEA104035599_01773)	coaB	1723139..1723828 (+)	690	WP_000699493.1	phosphopantothenate--cysteine ligase	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 51712.42 Da
• Isoelectric Point: 4.9706

>NTDB_id=1126573 E0F34_RS09290 WP_000886210.1 1717635..1718984(-) (micB) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide

• Length: 1350 bp

>NTDB_id=1126573 E0F34_RS09290 WP_000886210.1 1717635..1718984(-) (micB) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGTGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCACCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATTAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

• PAS fold (PAS) (98-198)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (324-434)

3D structure

• AlphaFold DB: A0A064BZM9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micB	Streptococcus pneumoniae Cp1015	99.777	100	0.998
vicK	Streptococcus mutans UA159	69.9	89.532	0.626