Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   E0F31_RS11020 Genome accession   NZ_LR216064
Coordinates   2048617..2048742 (-) Length   41 a.a.
NCBI ID   WP_000799686.1    Uniprot ID   P60242
Organism   Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2043617..2053742
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F31_RS12240 - 2043998..2045609 (-) 1612 Protein_2065 YhgE/Pip family protein -
  E0F31_RS10995 (SAMEA3714520_02078) - 2045737..2046279 (+) 543 WP_001158263.1 TetR/AcrR family transcriptional regulator -
  E0F31_RS11010 (SAMEA3714520_02081) comE 2046522..2047274 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  E0F31_RS11015 (SAMEA3714520_02082) comD/comD2 2047271..2048596 (-) 1326 WP_001842237.1 competence system sensor histidine kinase ComD Regulator
  E0F31_RS11020 (SAMEA3714520_02083) comC/comC2 2048617..2048742 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  E0F31_RS11030 (SAMEA3714520_02085) rlmH 2049024..2049503 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  E0F31_RS11035 (SAMEA3714520_02086) htrA 2049686..2050867 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  E0F31_RS11040 (SAMEA3714520_02087) spo0J 2050925..2051683 (+) 759 WP_050104049.1 ParB/RepB/Spo0J family partition protein Regulator
  E0F31_RS11045 (SAMEA3714520_02088) dnaA 2051896..2053257 (+) 1362 WP_000660618.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4907.00 Da        Isoelectric Point: 11.0006

>NTDB_id=1126312 E0F31_RS11020 WP_000799686.1 2048617..2048742(-) (comC/comC2) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=1126312 E0F31_RS11020 WP_000799686.1 2048617..2048742(-) (comC/comC2) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 6CJ8
  PDB 6COO
  PDB 6COP
  PDB 6COQ
  PDB 6COR
  PDB 6COS
  PDB 6COW
  PDB 6OBW
  PDB 6OC2
  PDB 6OC4
  PDB 6OLD
  PDB 6V1N

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

100

100

1
  comC/comC2 Streptococcus pneumoniae TIGR4

100

100

1
  comC/comC1 Streptococcus pneumoniae R6

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae G54

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae D39

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae Rx1

80.488

100

0.805
  comC Streptococcus mitis SK321

75.61

100

0.756
  comC Streptococcus mitis NCTC 12261

57.5

97.561

0.561

Multiple sequence alignment