Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   E0F31_RS11015 Genome accession   NZ_LR216064
Coordinates   2047271..2048596 (-) Length   441 a.a.
NCBI ID   WP_001842237.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2042271..2053596
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F31_RS12240 - 2043998..2045609 (-) 1612 Protein_2065 YhgE/Pip family protein -
  E0F31_RS10995 (SAMEA3714520_02078) - 2045737..2046279 (+) 543 WP_001158263.1 TetR/AcrR family transcriptional regulator -
  E0F31_RS11010 (SAMEA3714520_02081) comE 2046522..2047274 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  E0F31_RS11015 (SAMEA3714520_02082) comD/comD2 2047271..2048596 (-) 1326 WP_001842237.1 competence system sensor histidine kinase ComD Regulator
  E0F31_RS11020 (SAMEA3714520_02083) comC/comC2 2048617..2048742 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  E0F31_RS11030 (SAMEA3714520_02085) rlmH 2049024..2049503 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  E0F31_RS11035 (SAMEA3714520_02086) htrA 2049686..2050867 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  E0F31_RS11040 (SAMEA3714520_02087) spo0J 2050925..2051683 (+) 759 WP_050104049.1 ParB/RepB/Spo0J family partition protein Regulator
  E0F31_RS11045 (SAMEA3714520_02088) dnaA 2051896..2053257 (+) 1362 WP_000660618.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51441.05 Da        Isoelectric Point: 7.5816

>NTDB_id=1126311 E0F31_RS11015 WP_001842237.1 2047271..2048596(-) (comD/comD2) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
MDLLGFGTVIVHFLIISHSYRLICKGRINRKELYVFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVMVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=1126311 E0F31_RS11015 WP_001842237.1 2047271..2048596(-) (comD/comD2) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCG
AATAAATAGAAAAGAATTATACGTTTTTGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTC
TATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TGGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

99.546

100

0.995
  comD/comD1 Streptococcus pneumoniae Rx1

96.825

100

0.968
  comD/comD1 Streptococcus pneumoniae D39

96.825

100

0.968
  comD/comD1 Streptococcus pneumoniae R6

96.825

100

0.968
  comD Streptococcus mitis SK321

92.063

100

0.921
  comD Streptococcus mitis NCTC 12261

86.621

100

0.866
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.465

84.807

0.419

Multiple sequence alignment