Detailed information NTG1126188

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: E0F39_RS06245
• Genome accession: NZ_LR216060
• Coordinates: 1162894..1163598 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain GPSC47 substr. ST315
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1157894..1168598

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F39_RS06220 (SAMEA3713867_01180)	-	1159329..1160105 (-)	777	WP_001865265.1	potassium channel family protein	-
E0F39_RS06225 (SAMEA3713867_01181)	-	1160152..1160406 (-)	255	WP_001823540.1	type II toxin-antitoxin system RelE family toxin	-
E0F39_RS06230 (SAMEA3713867_01182)	relB	1160408..1160650 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
E0F39_RS06235 (SAMEA3713867_01183)	vicX	1160741..1161550 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
E0F39_RS06240 (SAMEA3713867_01184)	micB	1161552..1162901 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
E0F39_RS06245 (SAMEA3713867_01185)	micA	1162894..1163598 (-)	705	WP_000722076.1	response regulator YycF	Regulator
E0F39_RS06250 (SAMEA3713867_01186)	mutY	1163653..1164828 (-)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
E0F39_RS13050	-	1164925..1165050 (+)	126	WP_001818232.1	hypothetical protein	-
E0F39_RS06255 (SAMEA3713867_01187)	-	1165156..1166826 (-)	1671	WP_000845292.1	formate--tetrahydrofolate ligase	-
E0F39_RS06260 (SAMEA3713867_01188)	coaB	1167056..1167745 (+)	690	WP_000699493.1	phosphopantothenate--cysteine ligase	-
E0F39_RS06265 (SAMEA3713867_01189)	coaC	1167757..1168308 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=1126188 E0F39_RS06245 WP_000722076.1 1162894..1163598(-) (micA) [Streptococcus pneumoniae strain GPSC47 substr. ST315]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1126188 E0F39_RS06245 WP_000722076.1 1162894..1163598(-) (micA) [Streptococcus pneumoniae strain GPSC47 substr. ST315]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCACGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38