Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   E0F39_RS06240 Genome accession   NZ_LR216060
Coordinates   1161552..1162901 (-) Length   449 a.a.
NCBI ID   WP_000886210.1    Uniprot ID   A0A064BZM9
Organism   Streptococcus pneumoniae strain GPSC47 substr. ST315     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1156552..1167901
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F39_RS06215 (SAMEA3713867_01179) - 1157848..1159104 (+) 1257 WP_174234207.1 ISL3 family transposase -
  E0F39_RS06220 (SAMEA3713867_01180) - 1159329..1160105 (-) 777 WP_001865265.1 potassium channel family protein -
  E0F39_RS06225 (SAMEA3713867_01181) - 1160152..1160406 (-) 255 WP_001823540.1 type II toxin-antitoxin system RelE family toxin -
  E0F39_RS06230 (SAMEA3713867_01182) relB 1160408..1160650 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  E0F39_RS06235 (SAMEA3713867_01183) vicX 1160741..1161550 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  E0F39_RS06240 (SAMEA3713867_01184) micB 1161552..1162901 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  E0F39_RS06245 (SAMEA3713867_01185) micA 1162894..1163598 (-) 705 WP_000722076.1 response regulator YycF Regulator
  E0F39_RS06250 (SAMEA3713867_01186) mutY 1163653..1164828 (-) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  E0F39_RS13050 - 1164925..1165050 (+) 126 WP_001818232.1 hypothetical protein -
  E0F39_RS06255 (SAMEA3713867_01187) - 1165156..1166826 (-) 1671 WP_000845292.1 formate--tetrahydrofolate ligase -
  E0F39_RS06260 (SAMEA3713867_01188) coaB 1167056..1167745 (+) 690 WP_000699493.1 phosphopantothenate--cysteine ligase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51712.42 Da        Isoelectric Point: 4.9706

>NTDB_id=1126187 E0F39_RS06240 WP_000886210.1 1161552..1162901(-) (micB) [Streptococcus pneumoniae strain GPSC47 substr. ST315]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=1126187 E0F39_RS06240 WP_000886210.1 1161552..1162901(-) (micB) [Streptococcus pneumoniae strain GPSC47 substr. ST315]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACTAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAAACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCATCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTTTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

PAS fold (PAS)

(98-198)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064BZM9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

99.777

100

0.998
  vicK Streptococcus mutans UA159

69.9

89.532

0.626

Multiple sequence alignment