Detailed information NTG1126163

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: E0F32_RS12220
• Genome accession: NZ_LR216050
• Coordinates: 445914..446501 (+)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 440914..451501

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F32_RS02455 (SAMEA3431333_00458)	-	441167..441856 (-)	690	WP_000760532.1	CPBP family intramembrane glutamic endopeptidase	-
E0F32_RS02460 (SAMEA3431333_00459)	-	441908..442291 (-)	384	WP_000877381.1	hypothetical protein	-
E0F32_RS12215 (SAMEA3431333_00460)	-	442920..443278 (-)	359	Protein_467	immunity protein	-
E0F32_RS02480	-	443759..443878 (-)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
E0F32_RS12350	-	443881..443946 (-)	66	Protein_469	ComC/BlpC family peptide pheromone/bacteriocin	-
E0F32_RS02485	cipB	443982..444131 (-)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
E0F32_RS02495 (SAMEA3431333_00462)	blpK	444375..444623 (-)	249	WP_000379965.1	bacteriocin-like peptide BlpK	-
E0F32_RS02500 (SAMEA3431333_00463)	blpJ	444692..444961 (-)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
E0F32_RS02510 (SAMEA3431333_00464)	blpI	445428..445625 (-)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
E0F32_RS12220 (SAMEA3431333_00465)	comA/nlmT	445914..446501 (+)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
E0F32_RS02520 (SAMEA3431333_00466)	comA/nlmT	446428..448071 (+)	1644	WP_078133412.1	peptide cleavage/export ABC transporter	Regulator
E0F32_RS02525 (SAMEA3431333_00467)	-	448082..449443 (+)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
E0F32_RS02530 (SAMEA3431333_00468)	blpC	449500..449628 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
E0F32_RS02535 (SAMEA3431333_00469)	-	449699..451039 (-)	1341	WP_001017642.1	sensor histidine kinase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=1126163 E0F32_RS12220 WP_000205166.1 445914..446501(+) (comA/nlmT) [Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=1126163 E0F32_RS12220 WP_000205166.1 445914..446501(+) (comA/nlmT) [Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497