Detailed information NTG1123643

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EL254_RS09615
• Genome accession: NZ_LR134512
• Coordinates: 1852719..1853471 (-)
• Length: 250 a.a.
• NCBI ID: WP_001019939.1
• Uniprot ID: A0A0E1EJS7
• Organism: Streptococcus agalactiae strain NCTC13949
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1847719..1858471

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL254_RS09590 (NCTC13949_01891)	-	1848596..1849750 (-)	1155	WP_000623431.1	ABC transporter permease subunit	-
EL254_RS09595 (NCTC13949_01892)	-	1849756..1850604 (-)	849	WP_000926582.1	ABC transporter ATP-binding protein	-
EL254_RS09600	-	1850673..1850846 (-)	174	WP_000683599.1	hypothetical protein	-
EL254_RS09605 (NCTC13949_01893)	-	1851135..1851299 (+)	165	Protein_1765	cysteine peptidase family C39 domain-containing protein	-
EL254_RS09610 (NCTC13949_01894)	-	1851388..1852722 (-)	1335	WP_001089364.1	sensor histidine kinase	-
EL254_RS09615 (NCTC13949_01895)	comE/blpR	1852719..1853471 (-)	753	WP_001019939.1	response regulator transcription factor	Regulator
EL254_RS09625 (NCTC13949_01896)	-	1853687..1854502 (-)	816	WP_001029866.1	endonuclease/exonuclease/phosphatase family protein	-
EL254_RS09630 (NCTC13949_01897)	-	1854556..1856739 (-)	2184	WP_000795065.1	PTS transporter subunit IIBC	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29465.07 Da
• Isoelectric Point: 8.4441

>NTDB_id=1123643 EL254_RS09615 WP_001019939.1 1852719..1853471(-) (comE/blpR) [Streptococcus agalactiae strain NCTC13949]
MNIFILEDNFIQQARLERIIEEVKIRRSIHSKMVNTFEKPVQLLESICEKGMHNLYFLDIEIKNDEQRGLEVAKQIRQID
PYAQIVFVTTHSELMPLTFRYQVSALDYIDKGLSQEAFSRRIEEVLLYANNACSKNLLEDSFYFKSRYSQVQVPFNDILY
IETSLRSHRVVLYTAKDRMEFTATLGDILKQEPRLFQCHRSFLVNPLNIFKVDRSNKLIYLKNGSNCLISRNKIKDIMVV
IEENQRGRGI

Nucleotide

• Length: 753 bp

>NTDB_id=1123643 EL254_RS09615 WP_001019939.1 1852719..1853471(-) (comE/blpR) [Streptococcus agalactiae strain NCTC13949]
GTGAATATTTTTATTTTAGAGGATAATTTTATTCAACAGGCACGTTTAGAGAGAATAATTGAGGAAGTTAAAATTAGGAG
AAGTATACACAGTAAAATGGTAAATACCTTTGAAAAACCAGTTCAATTATTGGAATCAATCTGTGAAAAAGGTATGCATA
ATTTATATTTCTTAGACATTGAAATAAAAAATGATGAGCAGAGGGGCTTAGAGGTCGCAAAACAAATTAGACAAATTGAT
CCTTATGCTCAGATTGTTTTTGTTACAACTCATTCGGAATTAATGCCTTTAACCTTTCGTTATCAGGTATCAGCTTTAGA
CTATATCGATAAAGGACTTTCACAGGAAGCATTTAGCAGAAGGATTGAAGAAGTTTTACTATATGCTAATAATGCTTGCA
GTAAAAACTTACTAGAAGATTCTTTTTATTTTAAATCACGCTATAGTCAAGTACAAGTACCTTTTAACGATATCCTTTAT
ATAGAAACGTCATTAAGGTCACATAGAGTTGTCCTTTATACTGCAAAAGACAGAATGGAATTCACAGCCACTTTGGGGGA
TATTTTAAAACAAGAACCTAGGCTCTTTCAATGTCATCGCTCTTTTTTAGTAAATCCCTTGAATATTTTTAAAGTGGATA
GGTCAAATAAACTAATCTATTTAAAAAATGGTTCGAATTGTTTGATTTCTCGTAATAAAATAAAAGATATTATGGTAGTA
ATAGAGGAAAATCAAAGAGGTAGAGGAATATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-238)

3D structure

• AlphaFold DB: A0A0E1EJS7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	52.61	99.6	0.524
comE/comE1	Streptococcus equinus JB1	42.678	95.6	0.408
comE	Streptococcus pneumoniae D39	38.866	98.8	0.384
comE	Streptococcus pneumoniae R6	38.866	98.8	0.384
comE	Streptococcus pneumoniae TIGR4	38.866	98.8	0.384
comE	Streptococcus mitis SK321	38.866	98.8	0.384
comE	Streptococcus mitis NCTC 12261	38.866	98.8	0.384
comE	Streptococcus pneumoniae Rx1	38.866	98.8	0.384
comE	Streptococcus infantis strain Atu-4	36.8	100	0.368