Detailed information NTG1121536

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: EL133_RS05895
• Genome accession: NZ_LR134323
• Coordinates: 1148731..1149405 (-)
• Length: 224 a.a.
• NCBI ID: WP_006738882.1
• Uniprot ID: G5KG98
• Organism: Streptococcus urinalis strain NCTC13766
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1143731..1154405

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL133_RS05870 (NCTC13766_01218)	-	1144757..1145146 (-)	390	WP_006739964.1	cytidine deaminase	-
EL133_RS05875 (NCTC13766_01219)	-	1145267..1145854 (-)	588	WP_006738483.1	class I SAM-dependent methyltransferase	-
EL133_RS05880 (NCTC13766_01220)	coaA	1146136..1147056 (+)	921	WP_006740427.1	type I pantothenate kinase	-
EL133_RS05885 (NCTC13766_01221)	rpsT	1147110..1147361 (+)	252	WP_081479441.1	30S ribosomal protein S20	-
EL133_RS05890 (NCTC13766_01222)	ciaH	1147437..1148738 (-)	1302	WP_269208134.1	cell wall metabolism sensor histidine kinase WalK	Regulator
EL133_RS05895 (NCTC13766_01223)	ciaR	1148731..1149405 (-)	675	WP_006738882.1	response regulator transcription factor	Regulator
EL133_RS05900 (NCTC13766_01224)	-	1149509..1152046 (-)	2538	WP_006738772.1	M1 family metallopeptidase	-
EL133_RS05905 (NCTC13766_01225)	phoU	1152056..1152709 (-)	654	WP_006739252.1	phosphate signaling complex protein PhoU	-
EL133_RS05910 (NCTC13766_01226)	pstB	1152747..1153505 (-)	759	WP_006738781.1	phosphate ABC transporter ATP-binding protein PstB	-
EL133_RS05915 (NCTC13766_01227)	pstB	1153521..1154324 (-)	804	WP_006740422.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25488.26 Da
• Isoelectric Point: 4.3460

>NTDB_id=1121536 EL133_RS05895 WP_006738882.1 1148731..1149405(-) (ciaR) [Streptococcus urinalis strain NCTC13766]
MIKILLIEDDLSLSNSVFDFLDDFADVLQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGISTPVLIMTA
KEALDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKYNDSNLTYGDLVIDTSRKLALVDGNEIEFLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTKFGNDLQTLRSVGYMLKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=1121536 EL133_RS05895 WP_006738882.1 1148731..1149405(-) (ciaR) [Streptococcus urinalis strain NCTC13766]
ATGATAAAGATATTATTAATTGAAGACGATTTAAGTTTATCTAATTCTGTTTTTGACTTTTTAGATGATTTTGCTGATGT
TTTACAAGTGTTTGACGGTGAAGAAGGTCTTTACGAAGCTGAAAGTGGTGTTTACGACCTCATACTTTTAGATTTGATGT
TGCCTGAAAAAAATGGTTTTCAAGTACTAAAAGAACTTCGCGAAAAAGGAATTTCAACACCTGTTCTTATTATGACTGCC
AAAGAAGCATTAGACGATAAAGGTCACGGTTTTGAGCTTGGCGCTGATGATTATTTGACCAAACCATTTTATCTTGAAGA
ACTAAAAATGAGAATTCAAGCATTACTGAAACGTTCAGGTAAGTATAACGATTCCAATCTAACTTATGGAGATTTGGTAA
TTGATACTTCTAGGAAACTAGCCTTAGTTGATGGCAATGAAATTGAATTTCTAGGAAAAGAATTTGATCTACTAGTCTAT
TTTTTACAAAATCAAAATGTCATTTTGCCTAAATCTCAAATTTTTGATAGAATCTGGGGATTTGATAGTGACACAACAAT
TTCTGTAGTTGAAGTTTATGTTTCAAAAATTCGTAAAAAACTAAAAGGCACTAAATTTGGGAATGATTTACAAACATTAC
GCAGTGTGGGGTATATGCTAAAAAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: G5KG98

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	87.054	100	0.871
ciaR	Streptococcus pneumoniae Rx1	84.305	99.554	0.839
ciaR	Streptococcus pneumoniae D39	84.305	99.554	0.839
ciaR	Streptococcus pneumoniae R6	84.305	99.554	0.839
ciaR	Streptococcus pneumoniae TIGR4	84.305	99.554	0.839
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.054	100	0.371
micA	Streptococcus pneumoniae Cp1015	35.622	100	0.371
vicR	Streptococcus mutans UA159	34.746	100	0.366