Detailed information NTG1121405

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: EL130_RS01990
• Genome accession: NZ_LR134320
• Coordinates: 381639..382847 (-)
• Length: 402 a.a.
• NCBI ID: WP_002262650.1
• Uniprot ID: Q8DRQ6
• Organism: Streptococcus mutans strain NCTC10832
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 376639..387847

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL130_RS01970 (NCTC10832_00371)	-	377078..377269 (-)	192	WP_002262646.1	DUF951 domain-containing protein	-
EL130_RS01975 (NCTC10832_00372)	dnaN	377542..378678 (-)	1137	WP_002262647.1	DNA polymerase III subunit beta	-
EL130_RS01980 (NCTC10832_00373)	dnaA	378833..380191 (-)	1359	WP_002262648.1	chromosomal replication initiator protein DnaA	-
EL130_RS01985 (NCTC10832_00374)	spo0J	380393..381163 (-)	771	WP_002264637.1	ParB/RepB/Spo0J family partition protein	Regulator
EL130_RS01990 (NCTC10832_00375)	htrA	381639..382847 (-)	1209	WP_002262650.1	S1C family serine protease	Regulator
EL130_RS01995 (NCTC10832_00376)	rlmH	383053..383532 (+)	480	WP_002269936.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EL130_RS02000 (NCTC10832_00377)	-	383877..384539 (+)	663	WP_002283821.1	YoaK family protein	-

Sequence

Protein

• Length: 402 a.a.
• Molecular weight: 43071.55 Da
• Isoelectric Point: 8.8092

>NTDB_id=1121405 EL130_RS01990 WP_002262650.1 381639..382847(-) (htrA) [Streptococcus mutans strain NCTC10832]
MNNTKSHPFLKWFIPFLVIFLTFILGVISTLTFNWITGNKSFSNNGKTTVSNVIYDTKSNTTKAVKNVKNTVVSVINYQK
TDNSYYNYDSGSQEKNKSEDGLGVYGEGSGVIYKKDGDSAYLVTNNHVVKDAEKLEIMMANGKKVVGKLVGSDTYSDLAV
IKISSKYVTTVAEFANSDKIKVGEPAIAIGSPLGSDYANSVTEGIVSSLSRTVTSQNENGETISTNAIQTDAAINPGNSG
GALINIKGQVIGINSSKIASSNNSNSGVAVEGMGFAIPSNDVVSIINQLEENGEVVRPALGISMANLSEASTSGRDTLKI
PSDVTSGIVVLSTQSGMPADGKLKKYDVITEIDGKKVASISDLQSILYKHKKGDKIKLTFYREKDKQTVEIQLTKTSQDL
NH

Nucleotide

• Length: 1209 bp

>NTDB_id=1121405 EL130_RS01990 WP_002262650.1 381639..382847(-) (htrA) [Streptococcus mutans strain NCTC10832]
GTGAATAATACGAAATCTCACCCTTTTTTAAAATGGTTTATACCTTTTTTAGTTATTTTTTTAACTTTTATTTTAGGGGT
CATATCAACACTTACCTTTAATTGGATAACTGGTAACAAATCGTTTTCTAACAATGGAAAAACAACTGTTAGTAATGTCA
TTTATGATACCAAATCTAACACTACCAAGGCTGTTAAAAATGTCAAAAATACAGTTGTATCTGTCATCAATTATCAAAAA
ACAGATAATAGTTATTACAATTATGACAGCGGTTCTCAAGAAAAAAATAAATCAGAGGATGGTCTAGGAGTCTACGGTGA
AGGTTCTGGTGTTATCTACAAAAAAGATGGCGATAGTGCTTATTTAGTCACAAACAATCATGTCGTTAAAGATGCAGAAA
AGTTAGAAATCATGATGGCTAATGGTAAAAAAGTTGTCGGTAAATTAGTAGGTTCTGATACTTATTCTGATCTGGCTGTT
ATTAAAATTTCTTCTAAGTATGTTACGACAGTTGCTGAATTTGCTAATTCGGATAAAATAAAAGTTGGAGAACCAGCAAT
CGCTATTGGTAGCCCTTTAGGCAGTGATTATGCTAATTCTGTAACAGAAGGAATTGTTTCAAGTCTCAGTCGTACAGTAA
CTTCACAAAATGAAAATGGCGAAACAATTTCAACTAATGCTATTCAAACAGACGCAGCTATTAACCCTGGTAATTCTGGT
GGCGCTTTAATTAATATCAAAGGACAAGTTATTGGTATCAATTCAAGTAAAATTGCATCAAGTAATAACTCAAATAGTGG
CGTTGCTGTTGAAGGAATGGGCTTTGCAATTCCTTCAAACGATGTTGTCTCTATTATTAATCAATTAGAAGAAAATGGTG
AAGTTGTTAGACCCGCTCTTGGTATTTCAATGGCTAATCTTAGTGAAGCTTCAACAAGTGGAAGAGATACTTTAAAAATA
CCAAGTGATGTCACAAGTGGTATTGTTGTTCTTTCAACACAAAGTGGTATGCCAGCAGATGGAAAGCTGAAGAAATATGA
TGTCATTACAGAAATTGATGGGAAGAAGGTAGCTTCTATCAGCGATCTTCAAAGTATTCTTTACAAACACAAAAAGGGAG
ATAAAATTAAACTCACTTTCTATCGCGAAAAAGATAAACAAACAGTTGAGATCCAATTAACTAAAACAAGTCAAGATTTG
AATCATTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (298-393)

• Trypsin-like peptidase domain (Trypsin_2) (108-253)

• Peptidase family M50 (Peptidase_M50) (227-398)

3D structure

• AlphaFold DB: Q8DRQ6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	100	100	1
htrA	Streptococcus gordonii str. Challis substr. CH1	56.14	99.254	0.557
htrA	Streptococcus mitis NCTC 12261	54.684	98.259	0.537
htrA	Streptococcus pneumoniae Rx1	54.315	98.01	0.532
htrA	Streptococcus pneumoniae D39	54.315	98.01	0.532
htrA	Streptococcus pneumoniae R6	54.315	98.01	0.532
htrA	Streptococcus pneumoniae TIGR4	54.315	98.01	0.532