Detailed information NTG1121296

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: EL136_RS09120
• Genome accession: NZ_LR134317
• Coordinates: 1912709..1913623 (-)
• Length: 304 a.a.
• NCBI ID: WP_043039892.1
• Uniprot ID: A0A7Z8ZYG0
• Organism: Streptococcus equi subsp. zooepidemicus strain NCTC6180
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1907709..1918623

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL136_RS09100 (NCTC6180_01866)	-	1908564..1910345 (-)	1782	WP_154804244.1	acyltransferase family protein	-
EL136_RS09105 (NCTC6180_01867)	-	1910342..1910743 (-)	402	WP_012514718.1	MORN repeat-containing protein	-
EL136_RS09110 (NCTC6180_01868)	-	1910749..1911207 (-)	459	WP_012678781.1	low molecular weight protein-tyrosine-phosphatase	-
EL136_RS09115 (NCTC6180_01869)	ruvB	1911493..1912494 (-)	1002	WP_154804245.1	Holliday junction branch migration DNA helicase RuvB	-
EL136_RS11410 (NCTC6180_01870)	comS	1912528..1912626 (-)	99	WP_021320241.1	quorum-sensing system DWW-type pheromone	Regulator
EL136_RS09120 (NCTC6180_01871)	comR	1912709..1913623 (-)	915	WP_043039892.1	helix-turn-helix domain-containing protein	Regulator
EL136_RS09125 (NCTC6180_01872)	purB	1913922..1915214 (-)	1293	WP_043039910.1	adenylosuccinate lyase	-
EL136_RS09130 (NCTC6180_01873)	-	1915807..1916031 (-)	225	WP_014622100.1	hypothetical protein	-
EL136_RS09135 (NCTC6180_01874)	purK	1916046..1917119 (-)	1074	WP_043039891.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
EL136_RS09140 (NCTC6180_01875)	purE	1917106..1917594 (-)	489	WP_012514711.1	5-(carboxyamino)imidazole ribonucleotide mutase	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35746.33 Da
• Isoelectric Point: 4.5886

>NTDB_id=1121296 EL136_RS09120 WP_043039892.1 1912709..1913623(-) (comR) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
MLDNFGEKVRDLRYQKKITREDLCGDESELSIRQLARIELGQSIPSLSKVVFIAKALDVSVGFLTDGEDLELPKRYKELK
YLILRTPTYMDDDKLKLREEQFDEIFEDYYDQLPEEEKLVVDCLQSIMDTLLTENINFGVGLLQEYFEQTKSKTQFREND
LILIELYLAYLDIAGMNGEYSDKGFYDSLLDILLNQFEHFELEELFIVNKIAIGISSLSIKNNKPEILEKVIVLSQKIIL
KTQDFNRMPILNLIEWKYALMKKKDIEMAKKCYAKACLFAQLTGDQYLEKKLREEWGKDIKRYQ

Nucleotide

• Length: 915 bp

>NTDB_id=1121296 EL136_RS09120 WP_043039892.1 1912709..1913623(-) (comR) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
ATGTTAGACAATTTTGGTGAAAAGGTGAGAGACCTACGGTATCAGAAGAAGATTACCAGAGAGGATTTATGTGGAGATGA
GTCAGAATTATCCATTCGTCAATTAGCACGAATAGAATTGGGCCAATCGATTCCCAGCCTATCAAAGGTGGTTTTTATTG
CTAAGGCTCTGGACGTTAGTGTCGGCTTTTTGACAGACGGAGAGGATTTGGAGCTGCCTAAGCGTTATAAAGAACTTAAA
TATTTGATTTTAAGAACGCCGACCTATATGGATGATGACAAATTAAAGCTGCGAGAAGAGCAATTTGACGAAATTTTTGA
AGATTATTATGACCAGTTGCCAGAGGAAGAAAAGCTTGTGGTGGATTGCTTGCAGTCCATAATGGATACGTTATTAACCG
AGAATATCAATTTTGGAGTTGGGTTATTACAGGAATACTTTGAACAAACAAAAAGTAAGACTCAATTTAGAGAGAATGAT
CTCATTCTTATTGAGCTGTATTTAGCGTACCTCGACATTGCAGGAATGAATGGAGAGTATTCAGATAAAGGATTCTATGA
TTCTTTGTTAGACATTTTGTTAAATCAGTTTGAACATTTTGAATTAGAGGAATTATTTATTGTCAATAAAATAGCTATAG
GAATTTCCTCGTTGAGCATCAAAAACAATAAGCCGGAGATTCTTGAGAAGGTTATTGTACTTAGTCAAAAAATTATCCTC
AAGACTCAGGATTTTAATAGAATGCCTATCTTAAATTTGATAGAGTGGAAATATGCTCTAATGAAGAAAAAAGACATAGA
AATGGCCAAAAAATGCTATGCTAAGGCATGCCTGTTTGCTCAATTAACAGGAGATCAGTATTTGGAAAAGAAATTGAGAG
AAGAATGGGGTAAAGATATAAAACGATATCAATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix domain (HTH_19) (6-69)

• ComR tetratricopeptide (ComR_TPR) (73-296)

3D structure

• AlphaFold DB: A0A7Z8ZYG0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	74.587	99.671	0.743
comR	Streptococcus pyogenes MGAS315	54.817	99.013	0.543
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	52.069	95.395	0.497
comR	Streptococcus mutans UA159	48.829	98.355	0.48
comR	Streptococcus suis P1/7	38.255	98.026	0.375
comR	Streptococcus suis D9	37.542	99.013	0.372
comR	Streptococcus suis 05ZYH33	38.305	97.039	0.372