Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EL115_RS04860 Genome accession   NZ_LR134307
Coordinates   975040..975714 (-) Length   224 a.a.
NCBI ID   WP_049480971.1    Uniprot ID   -
Organism   Streptococcus milleri strain NCTC10708     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 970040..980714
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL115_RS04850 (NCTC10708_00977) - 971785..973233 (+) 1449 WP_049493216.1 alpha-amylase -
  EL115_RS04855 (NCTC10708_00978) ciaH 973704..975050 (-) 1347 WP_003068918.1 sensor histidine kinase Regulator
  EL115_RS04860 (NCTC10708_00979) ciaR 975040..975714 (-) 675 WP_049480971.1 response regulator transcription factor Regulator
  EL115_RS04865 (NCTC10708_00980) - 975980..976423 (-) 444 WP_037596942.1 hypothetical protein -
  EL115_RS04870 (NCTC10708_00981) - 976751..977509 (-) 759 WP_049480974.1 alpha/beta hydrolase -
  EL115_RS04875 (NCTC10708_00982) - 977972..978220 (+) 249 WP_003029583.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  EL115_RS04880 (NCTC10708_00983) - 978217..978513 (+) 297 WP_049477245.1 type II toxin-antitoxin system RelE family toxin -
  EL115_RS04885 (NCTC10708_00984) - 978620..979414 (-) 795 WP_049477244.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25400.11 Da        Isoelectric Point: 4.3228

>NTDB_id=1120889 EL115_RS04860 WP_049480971.1 975040..975714(-) (ciaR) [Streptococcus milleri strain NCTC10708]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKRLREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTINLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1120889 EL115_RS04860 WP_049480971.1 975040..975714(-) (ciaR) [Streptococcus milleri strain NCTC10708]
ATGATTAAGATTCTATTAGTAGAAGATGACCTTGGTTTATCTAACTCAGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAGGAAGGATTGTACGAAGCTGAAAGTGGTGTGTACGATCTTATCTTACTTGATTTGATGT
TACCGGAAAAAGACGGTTTTCAAGTATTGAAGAGATTACGTGAAAAAGGTGTTACAACACCGGTATTGATTATGACAGCT
AAAGAGAGTTTGAATGATAAAGGACATGGCTTTGAGCTGGGAGCCGACGATTATTTGACCAAACCATTTTATTTGGAAGA
GTTAAAAATGCGGATTCAAGCTCTTTTGAAACGATCGGGCAAGTTTAATGAAAATACTCTTTCTTATGGCGATGTAACCA
TTAATTTGTCAACGAACACTACACTTGTAGATGGAAATGAAGTAGAGTTACTCGGAAAAGAATTTGATTTATTAGTATAT
TTTTTGCAGAATCAAAATGTTATTCTACCGAAGACGCAGATTTTCGATCGCTTATGGGGGTTTGATAGTGATACAACCAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATTCGGAAAAAATTGAAAGGGACGACCTTTGCGAATAATCTTCAAACACTTC
GCAGCGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.071

100

0.911
  ciaR Streptococcus pneumoniae D39

91.071

100

0.911
  ciaR Streptococcus pneumoniae R6

91.071

100

0.911
  ciaR Streptococcus pneumoniae TIGR4

91.071

100

0.911
  ciaR Streptococcus mutans UA159

89.238

99.554

0.888
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.648

100

0.402
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

36.123

100

0.366

Multiple sequence alignment