Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   EL115_RS04855 Genome accession   NZ_LR134307
Coordinates   973704..975050 (-) Length   448 a.a.
NCBI ID   WP_003068918.1    Uniprot ID   -
Organism   Streptococcus milleri strain NCTC10708     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 968704..980050
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL115_RS04835 (NCTC10708_00974) rpsT 969121..969372 (+) 252 WP_020999623.1 30S ribosomal protein S20 -
  EL115_RS04840 (NCTC10708_00975) - 969437..969946 (+) 510 WP_037591165.1 DNA topology modulation protein -
  EL115_RS04845 (NCTC10708_00976) - 969994..971607 (-) 1614 WP_126441417.1 M20/M25/M40 family metallo-hydrolase -
  EL115_RS04850 (NCTC10708_00977) - 971785..973233 (+) 1449 WP_049493216.1 alpha-amylase -
  EL115_RS04855 (NCTC10708_00978) ciaH 973704..975050 (-) 1347 WP_003068918.1 sensor histidine kinase Regulator
  EL115_RS04860 (NCTC10708_00979) ciaR 975040..975714 (-) 675 WP_049480971.1 response regulator transcription factor Regulator
  EL115_RS04865 (NCTC10708_00980) - 975980..976423 (-) 444 WP_037596942.1 hypothetical protein -
  EL115_RS04870 (NCTC10708_00981) - 976751..977509 (-) 759 WP_049480974.1 alpha/beta hydrolase -
  EL115_RS04875 (NCTC10708_00982) - 977972..978220 (+) 249 WP_003029583.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  EL115_RS04880 (NCTC10708_00983) - 978217..978513 (+) 297 WP_049477245.1 type II toxin-antitoxin system RelE family toxin -
  EL115_RS04885 (NCTC10708_00984) - 978620..979414 (-) 795 WP_049477244.1 hypothetical protein -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50840.61 Da        Isoelectric Point: 10.0709

>NTDB_id=1120888 EL115_RS04855 WP_003068918.1 973704..975050(-) (ciaH) [Streptococcus milleri strain NCTC10708]
MLNKLKKAWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARKVGLDQKSENGE
PKSGTADKELTDKPNVSANTEVILFDKNYKPIITSNNFLGFNKLSFNSKQLDHIRQIQVKSNYGREETYRMILFEVKLPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMEASESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKIFRF
DNRIHRVIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTIAVKDNKPKGTIFEVKIAIRTDNKKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=1120888 EL115_RS04855 WP_003068918.1 973704..975050(-) (ciaH) [Streptococcus milleri strain NCTC10708]
ATGCTGAATAAACTAAAAAAAGCATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTTAT
TTTCTCAGCTATGACCTTGATTATCATTCAAGTTATGCGCTCAAGCCTTTATACAACGGTAGATAACAATTTAAAAAGCT
TGAGTCAAGATTCGGCTTCTGTGATTAATTTAGCACTTGCTCGAAAAGTAGGGCTAGATCAAAAGTCAGAAAATGGAGAG
CCTAAAAGTGGAACAGCTGACAAAGAATTGACAGATAAACCAAATGTTAGTGCCAATACAGAAGTTATTTTATTTGATAA
GAATTATAAGCCGATTATTACAAGCAATAATTTCTTAGGGTTCAATAAGCTTTCCTTTAATAGCAAGCAATTAGACCACA
TTCGTCAGATTCAAGTAAAAAGCAATTATGGTCGAGAAGAAACCTATCGAATGATTTTATTTGAGGTAAAACTGCCTAAT
TTAGAGACCAATGTCAAATACGCAGCGGTTTTTATCAATATCAGTCAATTGGAACAAACTAGTCAAAATCATGAACAGTT
GATTGTGGTGGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCTAGTGTTTATCTTGCACGGGTCAGTGTTAAACCTC
TTTTAGAAAGCATTCAAAAGCAAAAAAGTTTTGTCGAAAACGCTAGTCATGAGTTGCGTACACCTCTAGCTGTGTTGCAA
AATCGTTTGGAGACTTTATTTAGAAAGCCAGAAGCTACTATTATGGAAGCCAGTGAAAGCATTGCTTCTAGTTTGGATGA
AGTGCGGAATATGAAAATGTTGACGACAAATTTACTCAATCTAGCACGGCGTGACGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACAACTTTCACCAACTATGAAATGGTTGCCGCAGAGAATGGGAAAATTTTCCGATTT
GACAATAGGATTCACCGCGTAATTAAAACGGATAAAACCTTACTGAAGCAATTGATGACTATCTTGTTTGATAATGCCCT
GAAATATACAGATGAAGATGGTGTGATTGAATTGACAATCTCTGCAAATGATCGAAATTTGTTTTTGAAGGTTTCGGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCACGGACTCGGCAG
ACAGGTGGTTTTGGTTTAGGGTTGTCGCTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACCATTGCAGTGAAAGACAA
TAAGCCTAAAGGAACTATTTTTGAGGTGAAGATTGCGATTCGAACGGATAATAAAAAGAAAAAATAG

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

70.982

100

0.71
  ciaH Streptococcus pneumoniae D39

70.982

100

0.71
  ciaH Streptococcus pneumoniae R6

70.982

100

0.71
  ciaH Streptococcus pneumoniae TIGR4

70.982

100

0.71
  ciaH Streptococcus mutans UA159

55.023

97.768

0.538

Multiple sequence alignment