Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   EL092_RS10470 Genome accession   NZ_LR134291
Coordinates   2158965..2161118 (-) Length   717 a.a.
NCBI ID   WP_012131060.1    Uniprot ID   A8AZY5
Organism   Streptococcus gordonii strain NCTC7868     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2153965..2166118
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL092_RS10455 (NCTC7868_02089) purD 2154325..2155584 (-) 1260 WP_012131055.1 phosphoribosylamine--glycine ligase -
  EL092_RS10460 (NCTC7868_02090) lytF 2155829..2157478 (+) 1650 WP_012131057.1 GBS Bsp-like repeat-containing protein Regulator
  EL092_RS10465 (NCTC7868_02091) comB 2157597..2158955 (-) 1359 WP_012131059.1 competence pheromone export protein ComB Regulator
  EL092_RS10470 (NCTC7868_02092) comA 2158965..2161118 (-) 2154 WP_012131060.1 peptide cleavage/export ABC transporter ComA Regulator
  EL092_RS10475 (NCTC7868_02093) rpsD 2161572..2162183 (-) 612 WP_008810013.1 30S ribosomal protein S4 -
  EL092_RS10480 (NCTC7868_02094) - 2162449..2163171 (-) 723 WP_008810014.1 ABC transporter ATP-binding protein -
  EL092_RS10485 (NCTC7868_02095) - 2163171..2164169 (-) 999 WP_012131061.1 ABC transporter substrate-binding protein -
  EL092_RS10490 (NCTC7868_02096) - 2164213..2164965 (-) 753 WP_041789832.1 ABC transporter permease -
  EL092_RS10495 (NCTC7868_02097) - 2164928..2165218 (-) 291 WP_012131063.1 MTH1187 family thiamine-binding protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80740.81 Da        Isoelectric Point: 7.2115

>NTDB_id=1120403 EL092_RS10470 WP_012131060.1 2158965..2161118(-) (comA) [Streptococcus gordonii strain NCTC7868]
MKFRKQHYRAQVDTRDCGVAALAMIFGYYGSYFSLATLREKAKTTNDGTTALGLVKVAEGLNFETRAFKADMSLFDLEEV
SYPFIAHILKDGKLLHYYVVTGQDKHTIHIADPDPQVKMTKISRERFEQEWTGITIFLAPSPAYKPSQEKKNGLLDFIPL
LIKQKGLITNIVLATLLVTLINIVGSYYLQSIIDTYVPDHMKTTLGMISIGLIIVYILQQFLSYAQEYLLLVLGQRLSID
VILSYIKHVFQLPMSFFATRRTGEIVSRFTDANRIIDALASTILSIFLDVSIVSIIAIVLFSQNSSLFFLTLLGIPVYAL
IIFLFMKPFEKMNHETMEANSLLSSSIIEDINGIETIKSLTSEKQRYQKIDKEFVTYLKKSFAYGRSESLQKVLKAAARL
ILNVLILWLGATLVMDQKISLGQLITYNTLLVYFTNPLENIINLQTKLQSARVANERLNEVYLVKSEFEEKKLIKDLSHF
QADIDFRGVSYKYGYGANVLSEIDLHIPAGSKTSFVGVSGSGKTTLAKMMVHFYAPNQGDICLGGVNLNQLDKQALRQYI
NYLPQQPYVFNGTILENLLLGAREGTTQEDILRAVELAEIRSDIERMPLNYQTELSADGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIIDNLMVLDKTIIFIAHRLTIAERSEQVVVLDQGRIVESGSHKELIEREGFYHHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1120403 EL092_RS10470 WP_012131060.1 2158965..2161118(-) (comA) [Streptococcus gordonii strain NCTC7868]
ATGAAATTTAGGAAACAGCATTACAGAGCACAAGTTGACACTAGGGATTGCGGTGTTGCAGCTCTGGCTATGATTTTTGG
TTATTATGGATCGTATTTTTCCTTGGCTACACTACGAGAAAAGGCAAAAACGACTAATGATGGGACAACTGCTTTGGGTT
TGGTAAAAGTTGCTGAAGGACTGAACTTTGAGACGCGAGCTTTTAAAGCAGATATGAGCTTATTTGATCTGGAAGAGGTC
TCTTATCCTTTTATAGCGCATATCCTTAAGGATGGGAAGCTTCTGCATTATTATGTTGTAACGGGACAAGATAAACACAC
GATTCATATTGCAGACCCAGATCCTCAAGTTAAGATGACAAAGATTTCGCGAGAGCGTTTCGAACAGGAGTGGACAGGAA
TTACCATTTTCCTGGCTCCTAGTCCGGCCTATAAGCCTAGTCAGGAAAAGAAAAATGGGCTTTTAGATTTCATTCCCTTA
TTGATTAAACAGAAGGGATTGATTACTAATATTGTGCTTGCAACTTTGCTGGTAACGTTGATCAATATTGTTGGATCCTA
CTACCTTCAATCGATTATTGATACTTATGTGCCTGATCATATGAAAACGACGCTGGGTATGATTTCTATCGGCTTGATTA
TTGTCTATATTTTGCAGCAATTTTTGTCTTACGCCCAAGAATATTTGCTTTTGGTTTTAGGGCAGCGCCTATCGATTGAT
GTGATCTTATCCTATATCAAGCACGTTTTTCAGCTACCTATGTCATTTTTTGCGACAAGGCGGACAGGGGAAATCGTCTC
TCGTTTTACGGACGCCAATCGGATTATTGATGCCTTGGCCAGTACAATCTTGTCGATTTTCTTGGATGTGTCAATTGTGT
CGATCATTGCGATTGTTCTTTTTTCACAAAATAGCAGTCTTTTCTTTTTGACCTTGTTAGGAATCCCAGTTTACGCTCTC
ATTATTTTTCTTTTTATGAAGCCTTTTGAAAAGATGAATCATGAGACGATGGAAGCAAATAGTCTGTTGTCGTCTTCCAT
CATTGAAGATATCAATGGGATTGAAACGATCAAGTCTTTGACTAGCGAAAAACAACGTTATCAGAAGATTGACAAGGAAT
TTGTGACTTATCTGAAAAAGTCTTTTGCCTACGGGCGTTCTGAGAGTCTACAAAAAGTCTTGAAAGCGGCTGCTCGTTTG
ATTTTAAACGTCTTGATTTTATGGCTAGGAGCTACACTTGTCATGGATCAAAAAATCAGTCTTGGGCAGCTCATTACTTA
TAATACGCTTCTAGTCTACTTTACTAATCCTTTAGAAAATATTATCAATCTGCAAACGAAGTTACAGTCCGCACGAGTGG
CCAATGAGCGCCTCAATGAGGTCTATTTAGTTAAGTCTGAATTTGAAGAAAAGAAGCTTATTAAAGACTTGAGCCACTTT
CAGGCTGACATCGATTTTCGTGGAGTCAGTTATAAGTATGGCTATGGGGCCAATGTATTGTCAGAGATTGACTTGCATAT
TCCTGCTGGAAGTAAGACCAGCTTTGTTGGTGTATCCGGTTCAGGAAAAACAACCTTAGCCAAGATGATGGTGCATTTCT
ACGCACCAAATCAAGGAGATATTTGTCTGGGAGGAGTCAATCTCAATCAGTTAGATAAGCAGGCACTGCGCCAATATATC
AACTATCTTCCCCAGCAACCGTATGTTTTTAATGGAACTATTTTGGAAAATTTACTCTTAGGTGCGCGTGAAGGTACGAC
TCAAGAAGATATTCTGCGCGCGGTAGAGTTGGCGGAAATTAGGTCGGATATTGAGCGGATGCCCCTCAATTATCAGACAG
AGTTGTCTGCAGATGGTGCAGGAATCTCGGGTGGTCAACGTCAGCGTATTGCTCTAGCAAGGGCGCTCTTGACAGATGCG
CCAGTGCTTATCTTAGATGAAGCAACGAGTAGTCTGGATATTCTAACAGAGAAGCGGATCATTGATAATTTGATGGTGCT
TGATAAGACAATTATCTTTATTGCGCATCGTTTGACTATTGCGGAACGTTCGGAGCAGGTGGTCGTTTTGGATCAAGGGA
GAATTGTCGAGAGTGGAAGTCATAAGGAGCTGATCGAAAGAGAAGGCTTTTACCACCATTTGGTCAATAGTTAG

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(170-438)

ABC transporter (ABC_tran)

(500-650)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A8AZY5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus gordonii str. Challis substr. CH1

100

100

1
  comA Streptococcus mitis NCTC 12261

80.753

100

0.808
  comA Streptococcus pneumoniae Rx1

80.614

100

0.806
  comA Streptococcus pneumoniae D39

80.614

100

0.806
  comA Streptococcus pneumoniae R6

80.614

100

0.806
  comA Streptococcus mitis SK321

80.335

100

0.803
  comA Streptococcus pneumoniae TIGR4

80.195

100

0.802
  comA/nlmT Streptococcus mutans UA159

64.435

100

0.644

Multiple sequence alignment