Detailed information NTG1119999

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: EL078_RS08405
• Genome accession: NZ_LR134282
• Coordinates: 1681806..1682537 (-)
• Length: 243 a.a.
• NCBI ID: WP_074567288.1
• Uniprot ID: -
• Organism: Streptococcus equinus strain NCTC8140
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1676806..1687537

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL078_RS08370 (NCTC8140_01694)	comD/comD3	1677416..1678807 (-)	1392	WP_231997657.1	GHKL domain-containing protein	Regulator
EL078_RS08375 (NCTC8140_01695)	-	1678808..1679005 (-)	198	WP_126438119.1	hypothetical protein	-
EL078_RS08380 (NCTC8140_01696)	-	1679167..1679460 (-)	294	WP_024344358.1	bacteriocin immunity protein	-
EL078_RS08385 (NCTC8140_01697)	-	1679491..1679796 (-)	306	WP_033153382.1	bacteriocin immunity protein	-
EL078_RS08390 (NCTC8140_01698)	-	1679816..1680103 (-)	288	WP_164554332.1	DUF3884 family protein	-
EL078_RS08395 (NCTC8140_01699)	comC/comC1	1680300..1680455 (+)	156	WP_126438121.1	competence protein	Regulator
EL078_RS08400 (NCTC8140_01700)	comD/comD1	1680476..1681747 (-)	1272	WP_231997658.1	sensor histidine kinase	Regulator
EL078_RS08405 (NCTC8140_01701)	comE/comE1	1681806..1682537 (-)	732	WP_074567288.1	response regulator transcription factor	Regulator
EL078_RS09430 (NCTC8140_01704)	-	1683400..1683504 (-)	105	WP_231997659.1	bacteriocin class II family protein	-
EL078_RS08410 (NCTC8140_01706)	-	1684422..1685033 (-)	612	WP_231997660.1	thioredoxin family protein	-
EL078_RS08420 (NCTC8140_01708)	-	1685869..1685988 (-)	120	WP_126438123.1	bacteriocin	-
EL078_RS08425	-	1686357..1686683 (+)	327	Protein_1593	cysteine peptidase family C39 domain-containing protein	-

Sequence

Protein

• Length: 243 a.a.
• Molecular weight: 27968.81 Da
• Isoelectric Point: 5.9154

>NTDB_id=1119999 EL078_RS08405 WP_074567288.1 1681806..1682537(-) (comE/comE1) [Streptococcus equinus strain NCTC8140]
MLDIFILEDNITQQFRIERQIEAIMEKNNWAYQHLEAFAASEDIIAKASEKKSHQIFFLDLEIKGDEKQGIDVARAIREK
DSTAIIAFVTTHSEFMLLTYQSLVGAIDFIDKNLNDAAFEQRLELCLKEALKHQKGNLGENSYLFETAKARIRVAYDDIL
YFETSPTVHRVILHTKTGQTEFYGTIAEVAKSDERLFKCHRSFVINVNNVAEFDKSTRTAYFANGSYCQVSRDKVKSLMA
EMR

Nucleotide

• Length: 732 bp

>NTDB_id=1119999 EL078_RS08405 WP_074567288.1 1681806..1682537(-) (comE/comE1) [Streptococcus equinus strain NCTC8140]
ATGTTAGATATTTTTATCCTTGAGGATAATATCACACAACAATTTCGTATTGAGCGACAGATAGAGGCAATTATGGAAAA
GAATAATTGGGCTTATCAGCACTTGGAAGCTTTTGCGGCATCTGAGGATATTATTGCAAAAGCATCTGAAAAGAAGAGCC
ATCAGATTTTCTTTCTTGATTTAGAAATTAAAGGGGATGAAAAGCAAGGAATTGATGTGGCAAGAGCCATCCGTGAGAAG
GATTCGACAGCTATTATTGCTTTTGTAACGACTCATTCGGAGTTTATGCTTTTAACTTATCAGTCGTTGGTTGGTGCGAT
TGATTTCATTGATAAAAATTTAAATGATGCAGCTTTTGAACAACGTTTAGAGTTATGCTTGAAGGAAGCTCTTAAGCATC
AAAAAGGAAATTTAGGTGAGAATTCTTACCTTTTTGAAACTGCCAAAGCGAGAATTCGTGTAGCTTACGATGATATTTTA
TATTTTGAAACATCGCCAACCGTTCACCGAGTGATTTTACACACAAAAACAGGTCAAACTGAATTTTACGGAACGATTGC
GGAGGTTGCCAAATCAGATGAACGTCTGTTCAAATGTCACCGCTCTTTTGTGATTAATGTAAATAATGTTGCTGAATTTG
ATAAAAGTACCCGAACAGCTTATTTTGCAAATGGCTCTTACTGCCAAGTCTCACGAGACAAAGTCAAAAGCCTAATGGCA
GAAATGAGGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-240)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	87.243	100	0.872
comE/comE2	Streptococcus equinus JB1	47.521	99.588	0.473
comE/blpR	Streptococcus mutans UA159	46.058	99.177	0.457
comE/comE2	Streptococcus gordonii strain NCTC7865	35.341	100	0.362
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.341	100	0.362