Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EL078_RS04940 Genome accession   NZ_LR134282
Coordinates   965055..965729 (-) Length   224 a.a.
NCBI ID   WP_024344055.1    Uniprot ID   A0A239RAE4
Organism   Streptococcus equinus strain NCTC8140     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 960055..970729
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL078_RS04915 (NCTC8140_00992) deoC 960538..961203 (-) 666 WP_021142326.1 deoxyribose-phosphate aldolase -
  EL078_RS04920 (NCTC8140_00993) - 961706..962296 (-) 591 WP_126437853.1 class I SAM-dependent methyltransferase -
  EL078_RS04925 (NCTC8140_00994) coaA 962410..963330 (+) 921 WP_126437854.1 type I pantothenate kinase -
  EL078_RS04930 (NCTC8140_00995) rpsT 963406..963657 (+) 252 WP_004231769.1 30S ribosomal protein S20 -
  EL078_RS04935 (NCTC8140_00996) ciaH 963740..965065 (-) 1326 WP_024344056.1 sensor histidine kinase Regulator
  EL078_RS04940 (NCTC8140_00997) ciaR 965055..965729 (-) 675 WP_024344055.1 response regulator transcription factor Regulator
  EL078_RS04945 (NCTC8140_00998) - 965882..968425 (-) 2544 WP_126437855.1 M1 family metallopeptidase -
  EL078_RS04950 (NCTC8140_00999) phoU 968634..969287 (-) 654 WP_024344053.1 phosphate signaling complex protein PhoU -
  EL078_RS04955 (NCTC8140_01000) pstB 969319..970077 (-) 759 WP_024344052.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25372.99 Da        Isoelectric Point: 4.3773

>NTDB_id=1119979 EL078_RS04940 WP_024344055.1 965055..965729(-) (ciaR) [Streptococcus equinus strain NCTC8140]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGAEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGISTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNNNTLSYHELTADTSTNTTTVNGEKVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTSFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1119979 EL078_RS04940 WP_024344055.1 965055..965729(-) (ciaR) [Streptococcus equinus strain NCTC8140]
ATGATTAAAATTTTATTAGTAGAAGACGATTTGAGCTTGTCAAATTCAATTTTTGATTTTTTGGATGATTTTGCGGATGT
CATGCAGGTTTTTGATGGCGCAGAAGGTTTATATGAAGCAGAAAGTGGTGTTTATGACCTTATTTTGCTTGATTTGATGT
TGCCAGAAAAAGATGGTTTCCAAGTTCTTAAAGAATTACGTGAAAAAGGCATTTCAACACCTGTTTTGATTATGACAGCT
AAAGAAAGTCTTGATGACAAAGGACATGGATTTGAATTAGGTGCTGATGATTACCTAACAAAACCATTTTATCTTGAAGA
ACTTAAGATGCGTATTCAAGCTCTTTTAAAACGTTCAGGTAAATTTAATAACAATACTTTGTCATATCATGAATTAACTG
CGGATACTTCAACAAATACAACAACTGTTAATGGTGAAAAAGTTGAATTACTAGGTAAAGAGTTTGATTTGTTAGTATAC
TTTTTGCAAAACCAAAATGTCATTTTGCCAAAATCACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACAACAAT
TTCAGTTGTTGAAGTATATGTTTCAAAAATTCGTAAAAAACTCAAAGGTACTAGCTTTGCCAATAATCTTCAAACACTAC
GTAGTGTAGGTTACATATTGAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A239RAE4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

91.928

99.554

0.915
  ciaR Streptococcus pneumoniae Rx1

87.5

100

0.875
  ciaR Streptococcus pneumoniae D39

87.5

100

0.875
  ciaR Streptococcus pneumoniae R6

87.5

100

0.875
  ciaR Streptococcus pneumoniae TIGR4

87.5

100

0.875
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.767

100

0.393
  micA Streptococcus pneumoniae Cp1015

34.764

100

0.362
  vicR Streptococcus mutans UA159

34.764

100

0.362

Multiple sequence alignment