Detailed information NTG1117851

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ELZ47_RS11835
• Genome accession: NZ_LR134002
• Coordinates: 2358013..2359185 (+)
• Length: 390 a.a.
• NCBI ID: WP_002928599.1
• Uniprot ID: A0AAE8K9B5
• Organism: Streptococcus sanguinis strain NCTC 10904
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2353013..2364185

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ELZ47_RS11795 (NCTC10904_02323)	-	2353437..2354484 (-)	1048	Protein_2233	IS3 family transposase	-
ELZ47_RS11810 (NCTC10904_02327)	comE	2354794..2355558 (-)	765	WP_002899424.1	competence system response regulator transcription factor ComE	Regulator
ELZ47_RS11815	comD	2355564..2356897 (-)	1334	Protein_2235	competence system sensor histidine kinase ComD	-
ELZ47_RS11820 (NCTC10904_02330)	-	2356926..2357033 (-)	108	WP_126436088.1	competence protein	-
ELZ47_RS11830 (NCTC10904_02332)	rlmH	2357330..2357809 (-)	480	WP_126436089.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ELZ47_RS11835 (NCTC10904_02333)	htrA	2358013..2359185 (+)	1173	WP_002928599.1	S1C family serine protease	Regulator
ELZ47_RS11840 (NCTC10904_02334)	spo0J	2359249..2360010 (+)	762	WP_164549623.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 390 a.a.
• Molecular weight: 40901.67 Da
• Isoelectric Point: 4.7432

>NTDB_id=1117851 ELZ47_RS11835 WP_002928599.1 2358013..2359185(+) (htrA) [Streptococcus sanguinis strain NCTC 10904]
MKNSSNAIKRALFLFAVLIVGFIGGSLGNYVTTLLTSRVKMNGNSTTSVTTSYKNSTDISEAVKKVQNAVVSVITYAESS
SSVINDESSNDESQISSEGSGVIYKKDGKSAYLVTNTHVLNGSTNVDILLADGNKVPGEVVGSDVYSDISVVKISSEKVT
DVAEFGDSGSLTVGETAIAIGSPLGTEYANSVTQGIISSLGRNVTLQSENGENISTTALQTDAAINPGNSGGPLINIQGQ
VIGITSSKISTNGQTSVEGMGFAIPSNDVVNIINQLEKNGTVTRPALGIQMMDLSNLTTSDFSKLNLPASVKSGILVRSV
QQGMPADGKLQKNDIITKVDNTDVESTSDLQSALYKHSIGDEVEITYYRDGKSQTVKIKLTKSTKELSSN

Nucleotide

• Length: 1173 bp

>NTDB_id=1117851 ELZ47_RS11835 WP_002928599.1 2358013..2359185(+) (htrA) [Streptococcus sanguinis strain NCTC 10904]
ATGAAAAATTCTTCAAATGCCATCAAAAGGGCTTTATTTCTTTTTGCAGTATTAATTGTAGGTTTTATCGGCGGAAGTTT
AGGAAATTATGTTACTACATTATTAACTTCACGTGTAAAAATGAATGGAAATTCGACAACTAGTGTAACTACTTCATATA
AAAACTCTACAGACATTTCAGAAGCTGTGAAAAAGGTTCAAAATGCGGTTGTTTCAGTAATTACTTATGCTGAATCTTCT
AGCAGCGTTATCAATGATGAATCTTCCAACGATGAATCACAAATCTCCAGTGAAGGTTCTGGCGTAATTTATAAAAAAGA
TGGAAAATCAGCCTATCTGGTAACCAATACCCACGTTCTGAACGGATCAACCAATGTAGATATCTTGCTAGCTGATGGAA
ACAAGGTTCCAGGTGAAGTAGTCGGATCAGATGTTTATTCAGATATCTCTGTCGTTAAAATTAGCTCTGAAAAAGTAACT
GATGTCGCTGAATTTGGAGATTCTGGTTCTCTGACAGTTGGTGAAACAGCAATCGCCATCGGAAGCCCTCTTGGAACAGA
ATACGCTAACTCTGTAACACAAGGAATTATTTCTAGTTTAGGCAGAAACGTTACGTTACAATCTGAAAATGGTGAAAATA
TTTCAACAACTGCACTGCAAACAGATGCTGCCATTAACCCCGGTAACTCTGGCGGTCCGCTGATTAATATTCAAGGGCAA
GTAATTGGCATTACTTCAAGTAAAATTTCGACAAATGGCCAAACTTCTGTTGAAGGGATGGGATTTGCGATTCCATCTAA
TGATGTCGTAAATATTATCAATCAATTAGAGAAAAATGGAACAGTCACACGTCCTGCTTTAGGAATTCAAATGATGGATT
TATCTAATCTGACAACTTCTGATTTTTCTAAATTAAATCTTCCTGCTTCAGTGAAATCAGGTATTCTTGTTCGCTCTGTT
CAGCAAGGAATGCCTGCTGATGGCAAGCTTCAAAAAAATGATATCATTACAAAAGTAGATAATACAGATGTGGAATCCAC
TAGTGACCTTCAGTCTGCTCTCTACAAGCATAGTATTGGAGATGAAGTAGAGATTACTTATTATCGAGATGGTAAATCTC
AAACAGTCAAAATCAAACTCACTAAATCAACAAAAGAGTTAAGCTCAAATTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (99-244)

• PDZ domain (PDZ_2) (285-380)

• Peptidase family M50 (Peptidase_M50) (231-385)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	66.919	100	0.679
htrA	Streptococcus mitis NCTC 12261	63.613	100	0.641
htrA	Streptococcus pneumoniae Rx1	63.613	100	0.641
htrA	Streptococcus pneumoniae D39	63.613	100	0.641
htrA	Streptococcus pneumoniae R6	63.613	100	0.641
htrA	Streptococcus pneumoniae TIGR4	63.613	100	0.641
htrA	Streptococcus mutans UA159	54.177	100	0.549