Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   ELZ47_RS03975 Genome accession   NZ_LR134002
Coordinates   770051..770752 (+) Length   233 a.a.
NCBI ID   WP_002894937.1    Uniprot ID   A0A0B7GM19
Organism   Streptococcus sanguinis strain NCTC 10904     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 765051..775752
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ELZ47_RS03950 (NCTC10904_00775) - 765690..766172 (+) 483 WP_126435315.1 hypothetical protein -
  ELZ47_RS03955 (NCTC10904_00777) - 766384..767076 (+) 693 WP_185758705.1 AAA family ATPase -
  ELZ47_RS03960 (NCTC10904_00778) thrS 767073..769016 (+) 1944 WP_126435316.1 threonine--tRNA ligase -
  ELZ47_RS03965 (NCTC10904_00779) - 769108..769512 (-) 405 WP_125331412.1 hypothetical protein -
  ELZ47_RS03970 - 769622..769804 (-) 183 Protein_727 amino acid ABC transporter permease -
  ELZ47_RS03975 (NCTC10904_00780) micA 770051..770752 (+) 702 WP_002894937.1 response regulator YycF Regulator
  ELZ47_RS03980 (NCTC10904_00781) micB 770745..772094 (+) 1350 WP_125331413.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ELZ47_RS03985 (NCTC10904_00782) vicX 772104..772904 (+) 801 WP_125331414.1 MBL fold metallo-hydrolase Regulator
  ELZ47_RS03990 (NCTC10904_00783) - 772996..773355 (+) 360 WP_004186130.1 YbaN family protein -
  ELZ47_RS03995 (NCTC10904_00784) rnc 773477..774175 (+) 699 WP_002903151.1 ribonuclease III -

Sequence

Protein


Download         Length: 233 a.a.        Molecular weight: 26735.63 Da        Isoelectric Point: 4.7458

>NTDB_id=1117813 ELZ47_RS03975 WP_002894937.1 770051..770752(+) (micA) [Streptococcus sanguinis strain NCTC 10904]
MKKILVVDDEKPISDIIKFNMAKEGYEVLTAFDGKEALEMFEAEQPDILILDLMLPEVDGLEVARTIRKTSNVPIIVLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELQARVKALLRRADLVVENQVEESGPNELTIGELQILPDAFVAKKHGKELELTH
REFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide


Download         Length: 702 bp        

>NTDB_id=1117813 ELZ47_RS03975 WP_002894937.1 770051..770752(+) (micA) [Streptococcus sanguinis strain NCTC 10904]
ATGAAGAAAATATTAGTTGTAGATGATGAGAAGCCAATCTCAGATATTATTAAGTTTAATATGGCCAAAGAAGGCTATGA
GGTTTTGACTGCCTTTGATGGCAAGGAAGCCTTGGAAATGTTTGAGGCAGAACAGCCAGACATCTTGATTCTGGACTTGA
TGCTGCCAGAAGTGGACGGACTGGAAGTTGCTAGGACTATTCGTAAGACTAGTAATGTGCCGATTATTGTATTGTCTGCT
AAGGACAGTGAGTTTGACAAGGTTATCGGTCTTGAAATCGGTGCAGATGACTATGTGACCAAGCCTTTCTCAAATCGTGA
GCTGCAGGCGCGTGTCAAGGCACTTCTTCGTCGTGCAGACCTTGTGGTGGAAAACCAAGTGGAAGAAAGTGGTCCGAACG
AGCTGACCATTGGGGAACTGCAGATTTTGCCAGATGCTTTTGTAGCTAAGAAGCATGGCAAGGAGCTGGAGCTGACCCAC
CGTGAGTTTGAGTTGCTTCACCATTTGGCGACACATATTGGACAAGTGATGACACGTGAGCACTTGCTAGAAACAGTATG
GGGCTATGACTATTTTGGCGATGTCCGTACAGTGGATGTGACTATCCGCCGCCTGCGTGAAAAGATTGAAGATACGCCAA
GCCGGCCTGAGTATATCTTGACTCGCCGCGGAGTTGGCTACTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-228)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7GM19

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

82.833

100

0.828
  vicR Streptococcus mutans UA159

80.426

100

0.811
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.231

98.283

0.425
  covR Streptococcus salivarius strain HSISS4

42.174

98.712

0.416
  scnR Streptococcus mutans UA159

36.957

98.712

0.365

Multiple sequence alignment