Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EW023_RS05045 Genome accession   NZ_LR130239
Coordinates   971112..971786 (-) Length   224 a.a.
NCBI ID   WP_023612449.1    Uniprot ID   A0A5S4THL0
Organism   Streptococcus pyogenes strain PS003 isolate PS003     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 966112..976786
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW023_RS05020 - 966559..966948 (-) 390 WP_011285547.1 cytidine deaminase -
  EW023_RS05025 - 967601..968194 (-) 594 WP_032465601.1 class I SAM-dependent methyltransferase -
  EW023_RS05030 coaA 968462..969382 (+) 921 WP_010922353.1 type I pantothenate kinase -
  EW023_RS05035 rpsT 969436..969684 (+) 249 WP_164977038.1 30S ribosomal protein S20 -
  EW023_RS05040 ciaH 969809..971119 (-) 1311 WP_011054528.1 sensor histidine kinase Regulator
  EW023_RS05045 ciaR 971112..971786 (-) 675 WP_023612449.1 response regulator transcription factor Regulator
  EW023_RS05050 - 972133..974670 (-) 2538 WP_014407610.1 M1 family metallopeptidase -
  EW023_RS05060 phoU 974875..975528 (-) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  EW023_RS05065 pstB 975596..976354 (-) 759 WP_002993892.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25704.85 Da        Isoelectric Point: 4.5928

>NTDB_id=1116683 EW023_RS05045 WP_023612449.1 971112..971786(-) (ciaR) [Streptococcus pyogenes strain PS003 isolate PS003]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGEVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1116683 EW023_RS05045 WP_023612449.1 971112..971786(-) (ciaR) [Streptococcus pyogenes strain PS003 isolate PS003]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGTCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TCGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGGAAGTAGTTGAATTACTTGGTAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGGTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAATAGGCTTCAAACTTTAA
GAAGCGTAGGGTATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4THL0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus mutans UA159

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.667

100

0.388
  micA Streptococcus pneumoniae Cp1015

35.897

100

0.375
  vicR Streptococcus mutans UA159

35.897

100

0.375
  covR Streptococcus salivarius strain HSISS4

36.726

100

0.371

Multiple sequence alignment