Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   EW025_RS06355 Genome accession   NZ_LR130238
Coordinates   1229820..1230002 (-) Length   60 a.a.
NCBI ID   WP_011017964.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain HKU419 isolate HKU419     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1229820..1264830 1229820..1230002 within 0


Gene organization within MGE regions


Location: 1229820..1264830
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW025_RS06355 prx 1229820..1230002 (-) 183 WP_011017964.1 hypothetical protein Regulator
  EW025_RS06360 sda3 1230241..1231041 (+) 801 WP_011285611.1 streptodornase Sda3 -
  EW025_RS06365 - 1231312..1231746 (+) 435 WP_011017966.1 hypothetical protein -
  EW025_RS06370 - 1231816..1233021 (-) 1206 WP_010922446.1 glucosaminidase domain-containing protein -
  EW025_RS06375 - 1233137..1233364 (-) 228 WP_003058873.1 phage holin -
  EW025_RS06380 - 1233361..1233636 (-) 276 WP_002987582.1 hypothetical protein -
  EW025_RS06385 - 1233646..1234263 (-) 618 WP_011285613.1 DUF1366 domain-containing protein -
  EW025_RS06390 - 1234260..1234697 (-) 438 WP_011285614.1 DUF1617 family protein -
  EW025_RS06395 - 1234709..1236325 (-) 1617 WP_015446227.1 gp58-like family protein -
  EW025_RS10525 - 1236332..1236577 (-) 246 Protein_1182 phage tail spike protein -
  EW025_RS06400 - 1236574..1237269 (-) 696 WP_010922452.1 hypothetical protein -
  EW025_RS06405 - 1237266..1239623 (-) 2358 WP_010922453.1 hypothetical protein -
  EW025_RS06410 - 1239623..1239994 (-) 372 WP_010922454.1 DUF5361 domain-containing protein -
  EW025_RS06415 - 1240009..1240272 (-) 264 WP_010922455.1 hypothetical protein -
  EW025_RS06420 - 1240283..1240876 (-) 594 WP_010922456.1 tail protein -
  EW025_RS06425 - 1240888..1241223 (-) 336 WP_011285616.1 hypothetical protein -
  EW025_RS06430 - 1241224..1241460 (-) 237 WP_010922457.1 hypothetical protein -
  EW025_RS06435 - 1241453..1241791 (-) 339 WP_011285617.1 hypothetical protein -
  EW025_RS06440 - 1241751..1242173 (-) 423 WP_010922459.1 phage Gp19/Gp15/Gp42 family protein -
  EW025_RS06445 - 1242183..1242383 (-) 201 WP_010922460.1 hypothetical protein -
  EW025_RS06450 - 1242383..1243294 (-) 912 WP_010922461.1 phage major capsid protein -
  EW025_RS06455 - 1243319..1243780 (-) 462 WP_011285618.1 capsid assembly scaffolding protein Gp46 family protein -
  EW025_RS06460 - 1243861..1245276 (-) 1416 WP_011285619.1 terminase -
  EW025_RS06465 - 1245386..1245652 (-) 267 WP_010922464.1 hypothetical protein -
  EW025_RS06470 - 1245645..1245824 (-) 180 WP_015055972.1 hypothetical protein -
  EW025_RS06475 - 1245874..1246098 (-) 225 WP_010922466.1 hypothetical protein -
  EW025_RS06480 - 1246104..1247597 (-) 1494 WP_015446231.1 hypothetical protein -
  EW025_RS06485 - 1247590..1248858 (-) 1269 WP_010922468.1 phage portal protein -
  EW025_RS06490 - 1248855..1249211 (-) 357 WP_002994106.1 hypothetical protein -
  EW025_RS06495 - 1249360..1249704 (-) 345 WP_010922469.1 HNH endonuclease signature motif containing protein -
  EW025_RS06500 - 1249813..1250232 (-) 420 WP_010922470.1 DUF1492 domain-containing protein -
  EW025_RS06505 - 1250500..1251135 (-) 636 WP_010922070.1 N-6 DNA methylase -
  EW025_RS06510 - 1251137..1251406 (-) 270 WP_049525058.1 hypothetical protein -
  EW025_RS06515 - 1251490..1252002 (-) 513 WP_002988366.1 hypothetical protein -
  EW025_RS06520 - 1251999..1252340 (-) 342 WP_002988364.1 hypothetical protein -
  EW025_RS10170 - 1252518..1252685 (-) 168 WP_011285624.1 hypothetical protein -
  EW025_RS06525 - 1252695..1253492 (-) 798 WP_011285625.1 PD-(D/E)XK nuclease-like domain-containing protein -
  EW025_RS06530 - 1253489..1254418 (-) 930 WP_011285626.1 recombinase RecT -
  EW025_RS06535 - 1254421..1254750 (-) 330 WP_002988359.1 hypothetical protein -
  EW025_RS06540 - 1254806..1255012 (-) 207 WP_011017565.1 hypothetical protein -
  EW025_RS06545 - 1255021..1255161 (-) 141 WP_011017992.1 hypothetical protein -
  EW025_RS06550 - 1255158..1255391 (-) 234 WP_002985387.1 hypothetical protein -
  EW025_RS06555 - 1255372..1255761 (-) 390 WP_011285627.1 DnaD domain-containing protein -
  EW025_RS10355 - 1255906..1256145 (-) 240 WP_002985390.1 hypothetical protein -
  EW025_RS06565 - 1256245..1256430 (-) 186 WP_011285628.1 hypothetical protein -
  EW025_RS06570 - 1256432..1256743 (-) 312 WP_002990080.1 hypothetical protein -
  EW025_RS06575 - 1256821..1257006 (-) 186 WP_011054585.1 helix-turn-helix domain-containing protein -
  EW025_RS06580 - 1257173..1257412 (+) 240 WP_011284879.1 hypothetical protein -
  EW025_RS06585 - 1257554..1258360 (+) 807 WP_011285629.1 TIGR02391 family protein -
  EW025_RS06590 - 1258295..1258561 (-) 267 WP_010922204.1 hypothetical protein -
  EW025_RS06595 - 1258593..1259309 (-) 717 WP_011285630.1 phage antirepressor KilAC domain-containing protein -
  EW025_RS06600 - 1259321..1259512 (-) 192 WP_002993390.1 hypothetical protein -
  EW025_RS06605 - 1260148..1260243 (+) 96 WP_020837421.1 type I toxin-antitoxin system Fst family toxin -
  EW025_RS06610 - 1260666..1261013 (+) 348 WP_011285631.1 helix-turn-helix domain-containing protein -
  EW025_RS06615 - 1261017..1261397 (+) 381 WP_002994744.1 ImmA/IrrE family metallo-endopeptidase -
  EW025_RS06620 - 1261409..1261675 (+) 267 WP_011285632.1 DUF4177 domain-containing protein -
  EW025_RS06625 - 1261799..1262941 (+) 1143 WP_003051793.1 tyrosine-type recombinase/integrase -
  EW025_RS06630 - 1263031..1263306 (-) 276 WP_002983920.1 HU family DNA-binding protein -
  EW025_RS06635 - 1263405..1263992 (-) 588 WP_010922482.1 YpmS family protein -
  EW025_RS06640 - 1263970..1264812 (-) 843 WP_002992620.1 SGNH/GDSL hydrolase family protein -

Sequence

Protein


Download         Length: 60 a.a.        Molecular weight: 6841.79 Da        Isoelectric Point: 4.5183

>NTDB_id=1116622 EW025_RS06355 WP_011017964.1 1229820..1230002(-) (prx) [Streptococcus pyogenes strain HKU419 isolate HKU419]
MLTYDEFKQAIDNGYIAGDTVAIVRKDGQIFDYVLPHEKVKNGEVVTKEKVEEVLVELSR

Nucleotide


Download         Length: 183 bp        

>NTDB_id=1116622 EW025_RS06355 WP_011017964.1 1229820..1230002(-) (prx) [Streptococcus pyogenes strain HKU419 isolate HKU419]
ATGCTAACATACGACGAGTTTAAGCAAGCGATTGACAATGGATATATCGCAGGCGATACAGTAGCGATCGTGCGTAAAGA
CGGACAGATTTTTGATTATGTGTTGCCACATGAGAAAGTAAAGAATGGAGAAGTTGTGACTAAGGAAAAAGTGGAAGAGG
TGCTGGTGGAGCTTTCGAGATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS8232

100

100

1
  prx Streptococcus pyogenes MGAS315

85

100

0.85
  prx Streptococcus pyogenes MGAS315

80

100

0.8
  prx Streptococcus pyogenes MGAS315

73.333

100

0.733
  prx Streptococcus pyogenes MGAS315

90.244

68.333

0.617
  prx Streptococcus pyogenes MGAS315

83.721

71.667

0.6
  prx Streptococcus pyogenes MGAS315

78.571

70

0.55

Multiple sequence alignment