Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EW025_RS04985 Genome accession   NZ_LR130238
Coordinates   960877..961551 (-) Length   224 a.a.
NCBI ID   WP_010922355.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain HKU419 isolate HKU419     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 955877..966551
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW025_RS04960 - 956324..956713 (-) 390 WP_011285547.1 cytidine deaminase -
  EW025_RS04965 - 957372..957959 (-) 588 WP_011285548.1 class I SAM-dependent methyltransferase -
  EW025_RS04970 coaA 958227..959147 (+) 921 WP_010922353.1 type I pantothenate kinase -
  EW025_RS04975 rpsT 959201..959449 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  EW025_RS04980 ciaH 959574..960884 (-) 1311 WP_010922354.1 sensor histidine kinase Regulator
  EW025_RS04985 ciaR 960877..961551 (-) 675 WP_010922355.1 response regulator transcription factor Regulator
  EW025_RS04990 - 961897..964434 (-) 2538 WP_010922356.1 M1 family metallopeptidase -
  EW025_RS05000 phoU 964639..965292 (-) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  EW025_RS05005 pstB 965360..966118 (-) 759 WP_002993892.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25650.86 Da        Isoelectric Point: 4.6480

>NTDB_id=1116617 EW025_RS04985 WP_010922355.1 960877..961551(-) (ciaR) [Streptococcus pyogenes strain HKU419 isolate HKU419]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTCFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1116617 EW025_RS04985 WP_010922355.1 960877..961551(-) (ciaR) [Streptococcus pyogenes strain HKU419 isolate HKU419]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTATTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGCCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TTGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCTGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGATATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366

Multiple sequence alignment