Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   EW024_RS05990 Genome accession   NZ_LR130237
Coordinates   1172548..1172730 (-) Length   60 a.a.
NCBI ID   WP_011528776.1    Uniprot ID   A0A660A5W9
Organism   Streptococcus pyogenes strain SP444 isolate SP444     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1172548..1204658 1172548..1172730 within 0


Gene organization within MGE regions


Location: 1172548..1204658
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW024_RS05990 prx 1172548..1172730 (-) 183 WP_011528776.1 hypothetical protein Regulator
  EW024_RS05995 entC3 1172843..1173625 (-) 783 WP_002988472.1 enterotoxin type C3 EntC3 -
  EW024_RS06000 - 1173873..1174997 (-) 1125 WP_002988467.1 Fic family protein -
  EW024_RS06005 - 1175133..1176350 (-) 1218 WP_011528778.1 peptidoglycan amidohydrolase family protein -
  EW024_RS06010 - 1176469..1176696 (-) 228 WP_003058873.1 phage holin -
  EW024_RS06015 - 1176693..1176965 (-) 273 WP_011017397.1 hypothetical protein -
  EW024_RS06020 - 1176977..1177609 (-) 633 WP_011528779.1 hypothetical protein -
  EW024_RS06025 - 1177612..1178040 (-) 429 WP_011528780.1 DUF1617 family protein -
  EW024_RS06030 - 1178049..1179830 (-) 1782 WP_011528781.1 gp58-like family protein -
  EW024_RS06035 hylP 1179845..1180960 (-) 1116 WP_011528782.1 hyaluronoglucosaminidase -
  EW024_RS06040 - 1180957..1182933 (-) 1977 WP_011528783.1 phage tail spike protein -
  EW024_RS06045 - 1182915..1183610 (-) 696 WP_002992579.1 hypothetical protein -
  EW024_RS06050 - 1183607..1185964 (-) 2358 WP_011528784.1 hypothetical protein -
  EW024_RS06055 - 1185964..1186335 (-) 372 WP_011528785.1 DUF5361 domain-containing protein -
  EW024_RS06060 - 1186350..1186613 (-) 264 WP_003047548.1 hypothetical protein -
  EW024_RS06065 - 1186624..1187202 (-) 579 WP_014635577.1 hypothetical protein -
  EW024_RS06075 - 1187326..1187661 (-) 336 WP_011528787.1 hypothetical protein -
  EW024_RS06080 - 1187662..1187898 (-) 237 WP_000032787.1 hypothetical protein -
  EW024_RS06085 - 1187891..1188228 (-) 338 Protein_1121 hypothetical protein -
  EW024_RS06090 - 1188188..1188610 (-) 423 WP_011054682.1 phage Gp19/Gp15/Gp42 family protein -
  EW024_RS06095 - 1188620..1188820 (-) 201 WP_010922460.1 hypothetical protein -
  EW024_RS06100 - 1188820..1189731 (-) 912 WP_011528788.1 phage major capsid protein -
  EW024_RS06105 - 1189756..1190217 (-) 462 WP_010922462.1 capsid assembly scaffolding protein Gp46 family protein -
  EW024_RS06110 - 1190297..1191712 (-) 1416 WP_021299324.1 phage terminase large subunit-like protein -
  EW024_RS06115 - 1191794..1192030 (-) 237 Protein_1127 hypothetical protein -
  EW024_RS06120 - 1192032..1192298 (-) 267 WP_011054745.1 hypothetical protein -
  EW024_RS06125 - 1192350..1192574 (-) 225 WP_002994100.1 hypothetical protein -
  EW024_RS06130 - 1192580..1194073 (-) 1494 WP_010922467.1 hypothetical protein -
  EW024_RS06135 - 1194066..1195334 (-) 1269 WP_010922468.1 phage portal protein -
  EW024_RS06140 - 1195331..1195687 (-) 357 WP_002994106.1 hypothetical protein -
  EW024_RS06145 - 1195835..1196179 (-) 345 WP_011054690.1 HNH endonuclease signature motif containing protein -
  EW024_RS06150 - 1196287..1196706 (-) 420 WP_011528791.1 DUF1492 domain-containing protein -
  EW024_RS06155 - 1196885..1197212 (-) 328 Protein_1135 recombinase RecT -
  EW024_RS06160 - 1197215..1197544 (-) 330 WP_011528796.1 hypothetical protein -
  EW024_RS06165 - 1197600..1197806 (-) 207 WP_002988357.1 hypothetical protein -
  EW024_RS06170 - 1197815..1197955 (-) 141 WP_002988354.1 hypothetical protein -
  EW024_RS06175 - 1197952..1198186 (-) 235 Protein_1139 hypothetical protein -
  EW024_RS06180 - 1198167..1198370 (-) 204 Protein_1140 DNA replication protein -
  EW024_RS06185 - 1198367..1198963 (+) 597 Protein_1141 tyrosine-type recombinase/integrase -
  EW024_RS06190 - 1199052..1199327 (-) 276 WP_002983920.1 HU family DNA-binding protein -
  EW024_RS06195 - 1199426..1200013 (-) 588 WP_002989129.1 YpmS family protein -
  EW024_RS06200 - 1199991..1200833 (-) 843 WP_172594861.1 SGNH/GDSL hydrolase family protein -
  EW024_RS06205 - 1200826..1201665 (-) 840 WP_002989125.1 DegV family protein -
  EW024_RS06210 - 1201893..1202825 (-) 933 WP_011528800.1 LPXTG cell wall anchor domain-containing protein -
  EW024_RS06215 recN 1202997..1204658 (-) 1662 WP_002983909.1 DNA repair protein RecN -

Sequence

Protein


Download         Length: 60 a.a.        Molecular weight: 6840.81 Da        Isoelectric Point: 4.7023

>NTDB_id=1116573 EW024_RS05990 WP_011528776.1 1172548..1172730(-) (prx) [Streptococcus pyogenes strain SP444 isolate SP444]
MLTYNEFKQAIDNGYIAGDTVAIVRKDGQIFDYVLPHEKVKNGEVVTKEKVEEVLVELSR

Nucleotide


Download         Length: 183 bp        

>NTDB_id=1116573 EW024_RS05990 WP_011528776.1 1172548..1172730(-) (prx) [Streptococcus pyogenes strain SP444 isolate SP444]
ATGCTAACATACAACGAGTTTAAGCAAGCGATTGACAATGGATATATCGCAGGCGATACAGTAGCGATCGTGCGTAAAGA
CGGACAGATTTTTGATTATGTGTTGCCACATGAGAAAGTAAAGAATGGAGAAGTTGTGACTAAGGAAAAAGTGGAAGAGG
TGCTGGTGGAGCTTTCGAGATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A660A5W9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS8232

98.333

100

0.983
  prx Streptococcus pyogenes MGAS315

83.333

100

0.833
  prx Streptococcus pyogenes MGAS315

78.333

100

0.783
  prx Streptococcus pyogenes MGAS315

71.667

100

0.717
  prx Streptococcus pyogenes MGAS315

87.805

68.333

0.6
  prx Streptococcus pyogenes MGAS315

81.395

71.667

0.583
  prx Streptococcus pyogenes MGAS315

76.19

70

0.533

Multiple sequence alignment