Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   EW024_RS04180 Genome accession   NZ_LR130237
Coordinates   793382..793570 (+) Length   62 a.a.
NCBI ID   WP_011528571.1    Uniprot ID   A0A660A3N3
Organism   Streptococcus pyogenes strain SP444 isolate SP444     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 763687..793570 793382..793570 within 0


Gene organization within MGE regions


Location: 763687..793570
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW024_RS03995 recJ 763687..765897 (+) 2211 WP_011528535.1 single-stranded-DNA-specific exonuclease RecJ -
  EW024_RS04000 - 766048..766566 (+) 519 WP_002990109.1 adenine phosphoribosyltransferase -
  EW024_RS04005 - 766647..767330 (+) 684 WP_011184446.1 DnaD domain-containing protein -
  EW024_RS04010 nth 767327..767983 (+) 657 WP_002990106.1 endonuclease III -
  EW024_RS04015 - 768055..768741 (+) 687 WP_002990104.1 tRNA (adenine(22)-N(1))-methyltransferase -
  EW024_RS04020 - 768731..769519 (+) 789 WP_021299315.1 Nif3-like dinuclear metal center hexameric protein -
  EW024_RS04025 - 769559..770665 (+) 1107 WP_011528537.1 NAD(P)/FAD-dependent oxidoreductase -
  EW024_RS04030 rfbA 770723..771592 (+) 870 WP_002992970.1 glucose-1-phosphate thymidylyltransferase RfbA -
  EW024_RS04035 - 771592..772185 (+) 594 WP_002990099.1 dTDP-4-dehydrorhamnose 3,5-epimerase family protein -
  EW024_RS04040 rfbB 772429..773469 (+) 1041 WP_002984881.1 dTDP-glucose 4,6-dehydratase -
  EW024_RS04045 - 773552..774487 (-) 936 WP_060388510.1 tyrosine-type recombinase/integrase -
  EW024_RS04050 - 774634..774954 (+) 321 WP_002995960.1 VRR-NUC domain-containing protein -
  EW024_RS04055 - 774938..775294 (+) 357 WP_011018138.1 hypothetical protein -
  EW024_RS09520 - 775291..775542 (+) 252 WP_011528549.1 hypothetical protein -
  EW024_RS04065 - 775551..775760 (+) 210 Protein_732 DUF4355 domain-containing protein -
  EW024_RS04070 - 775779..776669 (+) 891 WP_011528556.1 hypothetical protein -
  EW024_RS04075 - 776681..776974 (+) 294 WP_011528557.1 HeH/LEM domain-containing protein -
  EW024_RS04080 - 776988..777332 (+) 345 WP_060388512.1 hypothetical protein -
  EW024_RS04085 - 777329..777640 (+) 312 WP_011528559.1 hypothetical protein -
  EW024_RS04090 - 777637..778032 (+) 396 WP_011528560.1 hypothetical protein -
  EW024_RS04095 - 778034..778444 (+) 411 WP_011528561.1 DUF5072 family protein -
  EW024_RS04100 - 778459..778713 (+) 255 WP_231494232.1 phage major tail protein, TP901-1 family -
  EW024_RS04105 - 778726..779016 (+) 291 WP_060388513.1 hypothetical protein -
  EW024_RS04110 - 778973..780550 (+) 1578 WP_231494234.1 phage tail protein -
  EW024_RS04115 - 780551..782035 (+) 1485 Protein_742 distal tail protein Dit -
  EW024_RS04120 - 782036..785485 (+) 3450 WP_011528567.1 glucosaminidase domain-containing protein -
  EW024_RS04125 - 785490..787352 (+) 1863 WP_011528568.1 DUF859 family phage minor structural protein -
  EW024_RS04130 - 787363..787710 (+) 348 WP_009880247.1 DUF1366 domain-containing protein -
  EW024_RS09480 - 787724..787846 (+) 123 WP_015055953.1 hypothetical protein -
  EW024_RS04135 - 787860..788183 (+) 324 WP_015055952.1 hypothetical protein -
  EW024_RS04140 - 788183..788515 (+) 333 WP_011054798.1 phage holin -
  EW024_RS04145 - 788517..789281 (+) 765 WP_011054797.1 CHAP domain-containing protein -
  EW024_RS04150 - 789293..789895 (+) 603 WP_011054796.1 hypothetical protein -
  EW024_RS04155 - 789906..790679 (+) 774 WP_011528569.1 hypothetical protein -
  EW024_RS04160 - 790689..790910 (+) 222 WP_009880241.1 hypothetical protein -
  EW024_RS04165 - 790910..791569 (+) 660 WP_011528570.1 hypothetical protein -
  EW024_RS04170 - 791638..792072 (-) 435 WP_011017966.1 hypothetical protein -
  EW024_RS04175 sda3 792344..793144 (-) 801 WP_011285611.1 streptodornase Sda3 -
  EW024_RS04180 prx 793382..793570 (+) 189 WP_011528571.1 hypothetical protein Regulator

Sequence

Protein


Download         Length: 62 a.a.        Molecular weight: 7224.11 Da        Isoelectric Point: 4.0606

>NTDB_id=1116567 EW024_RS04180 WP_011528571.1 793382..793570(+) (prx) [Streptococcus pyogenes strain SP444 isolate SP444]
MLTYDEFKQAIDREYITGDTVMIVRKNGQIFDYVLPHEEVRNGEVVTIERISDVMAELSESE

Nucleotide


Download         Length: 189 bp        

>NTDB_id=1116567 EW024_RS04180 WP_011528571.1 793382..793570(+) (prx) [Streptococcus pyogenes strain SP444 isolate SP444]
ATGCTAACATATGACGAGTTTAAGCAAGCAATCGACCGTGAATATATCACAGGAGACACAGTTATGATCGTGCGCAAGAA
CGGACAGATTTTTGATTATGTGTTGCCGCATGAAGAAGTGAGAAATGGGGAAGTTGTGACAATCGAGCGGATATCAGATG
TTATGGCAGAACTTTCTGAGTCTGAATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A660A3N3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

76.667

96.774

0.742
  prx Streptococcus pyogenes MGAS315

76.271

95.161

0.726
  prx Streptococcus pyogenes MGAS8232

76.271

95.161

0.726
  prx Streptococcus pyogenes MGAS315

71.667

96.774

0.694
  prx Streptococcus pyogenes MGAS315

90.698

69.355

0.629
  prx Streptococcus pyogenes MGAS315

85.366

66.129

0.565
  prx Streptococcus pyogenes MGAS315

76.19

67.742

0.516

Multiple sequence alignment