Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   EQB46_RS04725 Genome accession   NZ_LR129843
Coordinates   868311..868961 (+) Length   216 a.a.
NCBI ID   WP_000387335.1    Uniprot ID   A0A0B7MF65
Organism   Streptococcus pneumoniae strain 180-2 isolate 180-2     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 863311..873961
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQB46_RS04680 - 863795..864010 (+) 216 WP_001232082.1 YozE family protein -
  EQB46_RS04685 - 864096..865064 (+) 969 WP_000658183.1 PhoH family protein -
  EQB46_RS04695 - 865257..865757 (+) 501 WP_000566982.1 GNAT family N-acetyltransferase -
  EQB46_RS04700 - 865760..866085 (+) 326 Protein_895 TfoX/Sxy family protein -
  EQB46_RS11730 ald 866386..867497 (-) 1112 Protein_896 alanine dehydrogenase -
  EQB46_RS04720 - 867674..868243 (+) 570 WP_000443774.1 GNAT family N-acetyltransferase -
  EQB46_RS04725 comEA/celA/cilE 868311..868961 (+) 651 WP_000387335.1 helix-hairpin-helix domain-containing protein Machinery gene
  EQB46_RS04730 comEC/celB 868945..871185 (+) 2241 WP_000942414.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  EQB46_RS04735 - 871364..871552 (+) 189 WP_001809102.1 hypothetical protein -
  EQB46_RS04740 - 871584..872171 (+) 588 WP_000933542.1 ATP-binding cassette domain-containing protein -
  EQB46_RS04745 - 872175..873350 (+) 1176 WP_000655957.1 ABC transporter permease -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23229.61 Da        Isoelectric Point: 5.2344

>NTDB_id=1116342 EQB46_RS04725 WP_000387335.1 868311..868961(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain 180-2 isolate 180-2]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTNGEEAVSQQTGLGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=1116342 EQB46_RS04725 WP_000387335.1 868311..868961(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain 180-2 isolate 180-2]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAACCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTCGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAAAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAATGGAG
AAGAAGCAGTTAGCCAACAGACTGGTTTGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCT
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAATCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGCCAAGACTATAGAAAAGTTAAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(151-214)

SLBB domain (SLBB)

(76-126)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7MF65

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae Rx1

99.074

100

0.991
  comEA/celA/cilE Streptococcus pneumoniae D39

99.074

100

0.991
  comEA/celA/cilE Streptococcus pneumoniae R6

99.074

100

0.991
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

96.296

100

0.963
  comEA/celA/cilE Streptococcus mitis NCTC 12261

96.296

100

0.963
  comEA/celA/cilE Streptococcus mitis SK321

90.278

100

0.903
  comEA Lactococcus lactis subsp. cremoris KW2

43.172

100

0.454
  comEA Bacillus subtilis subsp. subtilis str. 168

41.053

87.963

0.361

Multiple sequence alignment