Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   EQB41_RS06460 Genome accession   NZ_LR129840
Coordinates   1205316..1206020 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 4496 isolate 4496     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1200316..1211020
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQB41_RS06430 - 1200508..1201494 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  EQB41_RS06435 - 1201784..1202527 (-) 744 WP_000725952.1 potassium channel family protein -
  EQB41_RS06440 - 1202574..1202828 (-) 255 WP_001823540.1 type II toxin-antitoxin system RelE family toxin -
  EQB41_RS06445 relB 1202830..1203072 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  EQB41_RS06450 vicX 1203163..1203972 (-) 810 WP_001289496.1 MBL fold metallo-hydrolase Regulator
  EQB41_RS06455 micB 1203974..1205323 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  EQB41_RS06460 micA 1205316..1206020 (-) 705 WP_000722076.1 response regulator YycF Regulator
  EQB41_RS06465 mutY 1206075..1207250 (-) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  EQB41_RS12625 - 1207347..1207472 (+) 126 WP_001818232.1 hypothetical protein -
  EQB41_RS06470 - 1207578..1209248 (-) 1671 WP_000845290.1 formate--tetrahydrofolate ligase -
  EQB41_RS06475 coaB 1209478..1210167 (+) 690 WP_000699488.1 phosphopantothenate--cysteine ligase -
  EQB41_RS06480 coaC 1210179..1210730 (+) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=1116194 EQB41_RS06460 WP_000722076.1 1205316..1206020(-) (micA) [Streptococcus pneumoniae strain 4496 isolate 4496]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=1116194 EQB41_RS06460 WP_000722076.1 1205316..1206020(-) (micA) [Streptococcus pneumoniae strain 4496 isolate 4496]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment