Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   EQB41_RS06455 Genome accession   NZ_LR129840
Coordinates   1203974..1205323 (-) Length   449 a.a.
NCBI ID   WP_000886210.1    Uniprot ID   A0A064BZM9
Organism   Streptococcus pneumoniae strain 4496 isolate 4496     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1198974..1210323
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQB41_RS06430 - 1200508..1201494 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  EQB41_RS06435 - 1201784..1202527 (-) 744 WP_000725952.1 potassium channel family protein -
  EQB41_RS06440 - 1202574..1202828 (-) 255 WP_001823540.1 type II toxin-antitoxin system RelE family toxin -
  EQB41_RS06445 relB 1202830..1203072 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  EQB41_RS06450 vicX 1203163..1203972 (-) 810 WP_001289496.1 MBL fold metallo-hydrolase Regulator
  EQB41_RS06455 micB 1203974..1205323 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  EQB41_RS06460 micA 1205316..1206020 (-) 705 WP_000722076.1 response regulator YycF Regulator
  EQB41_RS06465 mutY 1206075..1207250 (-) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  EQB41_RS12625 - 1207347..1207472 (+) 126 WP_001818232.1 hypothetical protein -
  EQB41_RS06470 - 1207578..1209248 (-) 1671 WP_000845290.1 formate--tetrahydrofolate ligase -
  EQB41_RS06475 coaB 1209478..1210167 (+) 690 WP_000699488.1 phosphopantothenate--cysteine ligase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51712.42 Da        Isoelectric Point: 4.9706

>NTDB_id=1116193 EQB41_RS06455 WP_000886210.1 1203974..1205323(-) (micB) [Streptococcus pneumoniae strain 4496 isolate 4496]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=1116193 EQB41_RS06455 WP_000886210.1 1203974..1205323(-) (micB) [Streptococcus pneumoniae strain 4496 isolate 4496]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCACCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

PAS fold (PAS)

(98-198)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064BZM9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

99.777

100

0.998
  vicK Streptococcus mutans UA159

69.9

89.532

0.626

Multiple sequence alignment