Detailed information NTG1114572

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: A66_RS05760
• Genome accession: NZ_LN847353
• Coordinates: 1123096..1123944 (-)
• Length: 282 a.a.
• NCBI ID: WP_053039645.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain A66
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 1118096..1128944

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A66_RS05745 (A66_01152)	-	1118451..1118810 (-)	360	WP_001237219.1	YbaN family protein	-
A66_RS05750 (A66_01153)	topA	1118916..1121003 (-)	2088	WP_053039644.1	type I DNA topoisomerase	-
A66_RS05755 (A66_01154)	-	1121170..1122213 (-)	1044	WP_041852777.1	TIGR00341 family protein	-
A66_RS12785 (A66_01155)	-	1122791..1122913 (+)	123	WP_001814242.1	hypothetical protein	-
A66_RS05760 (A66_01156)	dprA/cilB/dalA	1123096..1123944 (-)	849	WP_053039645.1	DNA-processing protein DprA	Machinery gene
A66_RS05765 (A66_01157)	-	1124041..1124730 (-)	690	WP_053039646.1	sugar phosphate nucleotidyltransferase	-
A66_RS05770 (A66_01158)	-	1124742..1125620 (-)	879	WP_000837617.1	DMT family transporter	-
A66_RS05775 (A66_01159)	licA	1125610..1126479 (-)	870	WP_000411207.1	choline kinase LicA	-
A66_RS05780 (A66_01160)	-	1126496..1127518 (-)	1023	WP_000609892.1	ribitol-5-phosphate dehydrogenase	-
A66_RS05785 (A66_01161)	-	1127523..1128230 (-)	708	WP_000638502.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31033.73 Da
• Isoelectric Point: 5.9645

>NTDB_id=1114572 A66_RS05760 WP_053039645.1 1123096..1123944(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain A66]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLALSEYGPGKQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=1114572 A66_RS05760 WP_053039645.1 1123096..1123944(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain A66]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTGCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATCTCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAGTCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAACAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGCTCTAAGTGAATATGGACCTGGCAAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACCTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGGTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	99.291	100	0.993
dprA/cilB/dalA	Streptococcus pneumoniae D39	99.291	100	0.993
dprA/cilB/dalA	Streptococcus pneumoniae R6	99.291	100	0.993
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	99.291	100	0.993
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	97.872	100	0.979
dprA/cilB/dalA	Streptococcus mitis SK321	97.163	100	0.972
dprA	Streptococcus mutans UA159	63.214	99.291	0.628
dprA	Lactococcus lactis subsp. cremoris KW2	55	99.291	0.546
dprA	Staphylococcus aureus N315	37.456	100	0.376
dprA	Haemophilus influenzae Rd KW20	38.202	94.681	0.362